Characterization of drug resistance mutations in naïve and ART-treated patients infected with HIV-1 in Yaounde, Cameroon

2012 ◽  
Vol 84 (5) ◽  
pp. 721-727 ◽  
Author(s):  
Laura Ceccarelli ◽  
Romina Salpini ◽  
Sylvie Moudourou ◽  
Valeria Cento ◽  
Maria M. Santoro ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv 1

Characterization of HIV-1 subtypes and drug resistance mutations among individuals infected with HIV in Georgia

2012 ◽  
Vol 84 (7) ◽  
pp. 1002-1008 ◽  
Author(s):  
Natia Dvali ◽  
Monica M. Parker ◽  
Nikoloz Chkhartishvili ◽  
Lali Sharvadze ◽  
Nino Gochitashvili ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv 1

Genetic characterization of HIV-1 strains in Togo reveals a high genetic complexity and genotypic drug-resistance mutations in ARV naive patients☆

2009 ◽  
Vol 9 (4) ◽  
pp. 646-652 ◽  
Author(s):  
Dagnra Anoumou Yaotsè ◽  
Vidal Nicole ◽  
Niama Fabien Roch ◽  
Prince-David Mireille ◽  
Delaporte Eric ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Genetic Characterization ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Genetic Complexity ◽  
Hiv 1

scholarly journals Human Immunodeficiency Virus type 1 Drug Resistance Mutations in Patients Failing Antiretroviral Therapy in Lebanon from 2009 to 2013

2021 ◽  
Vol 1 (1) ◽  
pp. 113-123
Author(s):  
Ahmad A. Hachem ◽  
Essa H. Hariri ◽  
Anthony Mansour ◽  
Jacques Mokhbat
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
Transcriptase Inhibitor ◽  
Resistance Mutations ◽  
Therapy Failure ◽  
Drug Resistance Mutations ◽  
Immunodeficiency Virus ◽  
Hiv 1

Background: Antiretroviral drug resistance remains a significant problem in the clinical management of patients infected with the Human Immunodeficiency Virus type-1. Aim: This study investigates and reports data on the molecular characterization of HIV-1 isolates from patients who are in a state of therapy failure. Methods: This is a retrospective study conducted on 65 patients in therapy failure. Inclusion criteria included patients diagnosed as being in therapy failure between the years 2009 and 2013. We defined ART failure as either a failure to achieve viral suppression or a failure to detect viral loads below 500 copies/mL after virological suppression in at least two plasma samples.  We used the published WHO list for surveillance of transmitted resistance and the Stanford HIV Drug Resistance Database to identify drug resistance mutations. Results: 65% of the participants had at least one drug resistance mutation (DRM). 12% of the population sampled had resistance to only one ART class, 32% presented with resistance to two classes of antiretroviral drugs, and 20% had resistance to all three classes of drugs. The prevalence of nucleoside transcriptase inhibitor (NRTI) mutations was 55%, the most common DRM being M184V. The prevalence of non-nucleoside reverse transcriptase inhibitor (NNRTI) mutations was 58%, with the most common mutation being the K103N mutation. The prevalence of protease inhibitors drug resistance mutations was 23%, with mutations V82A and I47V being present in 10% of the study population. Conclusion: Our study is the first molecular characterization of DRM emergence in HIV-1 strains from patients failing antiretroviral therapy in Lebanon. Continuous monitoring of resistance patterns for HIV in the country is necessary to tackle the emergent drug resistance.

scholarly journals The First Characterization of HIV-1 Subtypes and Drug Resistance Mutations among Antiretrovirally Treated Patients in Kermanshah, Iran

Intervirology ◽  
2017 ◽  
Vol 60 (1-2) ◽  
pp. 33-37 ◽  
Author(s):  
Reza Golmohammadi ◽  
Kazem Baesi ◽  
Abdolvahab Moradi ◽  
Molood Farrokhi ◽  
Willi McFarland ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv 1

Characterization of drug-resistance mutations in HIV-1 isolates from non-HAART and HAART treated patients in Burkina Faso

2006 ◽  
Vol 78 (11) ◽  
pp. 1385-1391 ◽  
Author(s):  
W.M. Nadembega ◽  
S. Giannella ◽  
J. Simpore ◽  
F. Ceccherini-Silberstein ◽  
V. Pietra ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Burkina Faso ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv 1

scholarly journals Characterization of HIV-1 subtypes and drug resistance mutations in Henan Province, China (2017–2019)

2020 ◽  
Vol 165 (6) ◽  
pp. 1453-1461
Author(s):  
Zhaojie Yang ◽  
Shuguang Wei ◽  
Jinjin Liu ◽  
Junyan Piao ◽  
Lixia Xu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Henan Province ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv 1
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