Longitudinal analysis of frequency and reactivity of epstein-barr virus-specific T lymphocytes and their association with intermittent viral reactivation

2011 ◽  
Vol 84 (1) ◽  
pp. 119-131 ◽  
Author(s):  
Bastian A. Vogl ◽  
Ursula Fagin ◽  
Linda Nerbas ◽  
Peter Schlenke ◽  
Peter Lamprecht ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Longitudinal Analysis ◽  
Epstein Barr Virus ◽  
Viral Reactivation ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Absence of allogeneic restriction in human T-cell-mediated cytotoxicity to Epstein-Barr virus-infected target cells. Demonstration of an HLA-linked control at the effector level.

1979 ◽  
Vol 150 (6) ◽  
pp. 1310-1322 ◽  
Author(s):  
M Lipinski ◽  
W H Fridman ◽  
T Tursz ◽  
C Vincent ◽  
D Pious ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Cell Surface ◽  
Target Cell ◽  
Epstein Barr Virus ◽  
Target Cells ◽  
Specific Lysis ◽  
Barr Virus ◽  
Positive Target ◽  
Epstein Barr

Peripheral T lymphocytes from patients with infectious mononucleosis (IM) are sensitized in vivo against the Epstein-Barr virus (EBV). The expression of HLA-A, B, or C molecules at the target cell surface is necessary for the cytotoxic reaction because (a) EBV-positive Daudi cells lacking HLA-A, B, and C determinants are resistant to anti-EBV T-cell lysis, (b) cytolysis of EBV-positive target cells can be consistently inhibited by anti-HLA-A, B, and C and anti-beta 2 microglobulin antibodies. However, no evidence for allogeneic restriction in this system was apparent as (a) cytotoxic T lymphocytes (CTL) from one given individual could exert a cytotoxicity of a similar magnitude on different EBV-positive target cells, regardless of the number of HLA-A or B specificities shared by the effectors and targets; (b) CTL from IM patients were able to kill target cells without any HLA-A or B antigen in common; and (c) T5-1 variants lacking one or two HLA antigens at the A, B, or D locus are killed to the same extent as the parental cells. 7 of the 9 IM patients with detectable circulating anti-EBV CTL carried the HLA-A1 antigen, whereas none of the 16 IM patients lacking detectable peripheral CTL were HLA-A1 positive (mean specific lysis of T5-1 target cells by T cells from HLA-A1 positive patients: 29.3 vs. 0.6% in HLA-A1-negative patients) (P less than 10(-9)). These data suggest an HLA-A1-linked gene control of the magnitude of the anti-EBV CTL response. Thus, the HLA region appears to act at two different level sin the T-cell-mediated lysis of EBV-infected cells by controlling first, the development of anti-EBV and second, the expression of HLA-A, B, and C molecules involved as recognition structures at the target cell surface.

Association of HTLV-III with Epstein-Barr Virus Infection and Abnormalities of T Lymphocytes in Homosexual Men

1986 ◽  
Vol 154 (4) ◽  
pp. 556-561 ◽  
Author(s):  
C. R. Rinaldo ◽  
L. A. Kingsley ◽  
D. W. Lyter ◽  
B. S. Rabin ◽  
R. W. Atchison ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Homosexual Men ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

scholarly journals Identification of naturally processed and HLA-presented Epstein-Barr virus peptides recognized by CD4+ or CD8+ T lymphocytes from human blood

1999 ◽  
Vol 96 (21) ◽  
pp. 12033-12038 ◽  
Author(s):  
W. Herr ◽  
E. Ranieri ◽  
A. Gambotto ◽  
L. S. Kierstead ◽  
A. A. Amoscato ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Human Blood ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Cd8 T Lymphocytes ◽  
Epstein Barr

scholarly journals Development of suppressor T lymphocytes for Epstein-Barr virus-induced B-lymphocyte outgrowth during acute infectious mononucleosis: assessment by two quantitative systems

Blood ◽  
1981 ◽  
Vol 57 (3) ◽  
pp. 510-517 ◽  
Author(s):  
RT Schooley ◽  
BF Haynes ◽  
J Grouse ◽  
C Payling-Wright ◽  
AS Fauci ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
B Lymphocytes ◽  
Epstein Barr Virus ◽  
B Lymphocyte ◽  
Acute Stage ◽  
Cell Mediated Immunity ◽  
Barr Virus ◽  
Epstein Barr

Abstract A system of 3H-thymidine incorporation by lymphocytes in culture for 3 wk has been utilized for quantitative assessment of the ability of T lymphocytes to inhibit outgrowth of autologous Epstein-Barr virus (EBV) transformed B lymphocytes. Lymphocytes from EBV-seronegative individuals lack the ability to suppress outgrowth of autologous EBV- transformed B lymphocytes. This capability appears during the course of primary EBV-induced infectious mononucleases (IM) as the atypical lymphocytosis is subsiding and persists for years after recovery from primary EBV infection. The ability of T lymphocytes from EBV- seropositive subjects or convalescent IM patients to inhibit B- lymphocyte outgrowth is not HLA restricted. Thus, T lymphocytes capable of inhibition of in vitro EBV-induced B-cell outgrowth emerge during the acute stage of IM and may represent an important control mechanism of EBV-induced B-lymphocyte proliferation in vivo. The system provides a highly sensitive quantitative means for in vitro assessment of cell- mediated immunity to EBV.

Epstein-Barr virus genome-positive T lymphocytes in a boy with chronic active EBV infection associated with Kawasaki-like disease

Nature ◽  
1988 ◽  
Vol 333 (6172) ◽  
pp. 455-457 ◽  
Author(s):  
Hideaki Kikuta ◽  
Yuichi Taguchi ◽  
Kazuhiro Tomizawa ◽  
Kimikazu Kojima ◽  
Nobuaki Kawamura ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Epstein Barr Virus ◽  
Virus Genome ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr

Longitudinal dynamics of antigen-specific CD8+cytotoxic T lymphocytes following primary Epstein-Barr virus infection

Blood ◽  
2001 ◽  
Vol 98 (8) ◽  
pp. 2588-2589 ◽  
Author(s):  
Mandvi Bharadwaj ◽  
Scott R. Burrows ◽  
Jacqueline M. Burrows ◽  
Denis J. Moss ◽  
Michelle Catalina ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Virus Infection ◽  
Cytotoxic T Lymphocytes ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Longitudinal Dynamics ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Melanoma-specific CD4+ T lymphocytes recognize human melanoma antigens processed and presented by epstein-barr virus-transformed B cells

1994 ◽  
Vol 58 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Suzanne L. Topalian ◽  
Licia Rivoltini ◽  
Marie Mancini ◽  
Jennifer Ng ◽  
Robert J. Hartzman ◽  
...  
Keyword(s):  
B Cells ◽  
T Lymphocytes ◽  
Epstein Barr Virus ◽  
Human Melanoma ◽  
Barr Virus ◽  
Melanoma Antigens ◽  
Epstein Barr
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