Functional profile of cytomegalovirus (CMV)-specific CD8+ T cells and kinetics of NKG2C+ NK Cells associated with the resolution of CMV DNAemia in allogeneic stem cell transplant recipients

2011 ◽  
Vol 84 (2) ◽  
pp. 259-267 ◽  
Author(s):  
Beatriz Muñoz-Cobo ◽  
Carlos Solano ◽  
Isabel Benet ◽  
Elisa Costa ◽  
María José Remigia ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Cd8 T Cells ◽  
Stem Cell Transplant ◽  
Cell Transplant ◽  
Allogeneic Stem Cell Transplant ◽  
Transplant Recipients ◽  
Functional Profile ◽  
Kinetics Of ◽  
Cmv Dnaemia

scholarly journals Monitoring of Trough Plasma Ganciclovir Levels and Peripheral Blood Cytomegalovirus (CMV)-Specific CD8+T Cells To Predict CMV DNAemia Clearance in Preemptively Treated Allogeneic Stem Cell Transplant Recipients

2014 ◽  
Vol 58 (9) ◽  
pp. 5602-5605 ◽  
Author(s):  
Estela Giménez ◽  
Carlos Solano ◽  
José Ramón Azanza ◽  
Paula Amat ◽  
David Navarro
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Stem Cell Transplant ◽  
Response To Therapy ◽  
Cell Transplant ◽  
Allogeneic Stem Cell Transplant ◽  
Transplant Recipients ◽  
Immunological Monitoring ◽  
Trough Plasma ◽  
Cmv Dnaemia

ABSTRACTIt is uncertain whether monitoring plasma ganciclovir (GCV) levels is useful in predicting cytomegalovirus (CMV) DNAemia clearance in preemptively treated allogeneic stem cell transplant recipients. In this observational study, including 13 episodes of CMV DNAemia treated with intravenous (i.v.) GCV or oral valganciclovir, we showed that monitoring trough plasma GCV levels does not reliably predict response to therapy. Rather, immunological monitoring (pp65 and immediate-early [IE]-1-specific gamma interferon [IFN-γ]-producing CD8+T cells) appeared to perform better for this purpose.

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