HIV-1 primary and secondary antiretroviral drug resistance and genetic diversity among pregnant women from central Brazil

2010 ◽  
Vol 82 (3) ◽  
pp. 351-357 ◽  
Author(s):  
Ludimila Paula Vaz Cardoso ◽  
Gisner Alves Souza Pereira ◽  
Ângela Alves Viegas ◽  
Luiza Emylce Pelá Rosado Schmaltz ◽  
Mariane Martins de Araújo Stefani
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Pregnant Women ◽  
Central Brazil ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Hiv 1

scholarly journals Genetic Diversity and Antiretroviral Drug Resistance among Drug-Naïve HIV-1 Infected Pregnant Women Attending Antenatal Clinics in Abidjan, Côte d'Ivoire

2012 ◽  
Vol 02 (02) ◽  
pp. 57-63
Author(s):  
Loukou Yao Guillaume ◽  
Zinzendorf Nanga Yessé ◽  
Kouadio Hortense ◽  
Djé Laurent ◽  
Cablan Mian Arsher ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Pregnant Women ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Antenatal Clinics ◽  
Hiv 1

scholarly journals HIV-1 Antiretroviral Drug Resistance in Pregnant Women in Jamaica: A Preliminary Report

2014 ◽  
Author(s):  
II Amarakoon ◽  
A Ramkissoon ◽  
R Pierre ◽  
LM Eysaguirre ◽  
JK Carr ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pregnant Women ◽  
Preliminary Report ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Hiv 1

scholarly journals HIV-1 subtypes and mutations associated to antiretroviral drug resistance in human isolates from Central Brazil

2004 ◽  
Vol 35 (3) ◽  
pp. 187-192 ◽  
Author(s):  
Daniela Marreco Cerqueira ◽  
Eduardo Dias Ramalho ◽  
Claudiner Pereira Oliveira ◽  
Ruiter Roberto Silva ◽  
Miriam Franchini ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Central Brazil ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Hiv 1

scholarly journals HIV-1 genetic diversity and antiretroviral drug resistance among individuals from Roraima state, northern Brazil

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0173894 ◽  
Author(s):  
André de Lima Guerra Corado ◽  
Gonzalo Bello ◽  
Renato Augusto Carvalho Leão ◽  
Fabiana Granja ◽  
Felipe Gomes Naveca
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Northern Brazil ◽  
Hiv 1

scholarly journals Lower genetic variability of HIV-1 and antiretroviral drug resistance in pregnant women from the state of Pará, Brazil

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Luiz Fernando Almeida Machado ◽  
Iran Barros Costa ◽  
Maria Nazaré Folha ◽  
Anderson Levy Bessa da Luz ◽  
Antonio Carlos Rosário Vallinoto ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Genetic Variability ◽  
Pregnant Women ◽  
The State ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Hiv 1

scholarly journals Correction to: HIV-1 genetic diversity, geographical linkages and antiretroviral drug resistance among individuals from Pakistan

2017 ◽  
Vol 163 (1) ◽  
pp. 41-41
Author(s):  
Saeed Khan ◽  
Maria Zahid ◽  
Muhammad Asif Qureshi ◽  
Nouman Mughal ◽  
Ikram Din Ujjan
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Hiv 1

HIV-1 genetic diversity, geographical linkages and antiretroviral drug resistance among individuals from Pakistan

2017 ◽  
Vol 163 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Saeed Khan ◽  
Maria Zahid ◽  
Muhammad Asif Qureshi ◽  
Muhammad Nouman Mughal ◽  
Ikram Din Ujjan
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Hiv 1

scholarly journals ACQUIRED ANTIRETROVIRAL DRUG RESISTANCE MUTATIONS UPON TREATMENT FAILURE IN HIV-1 INFECTED PEDIATRIC PATIENTS IN CENTRAL BRAZIL

2020 ◽  
Vol 49 (2) ◽  
pp. 79-93
Author(s):  
Maly Albuquerque ◽  
Solomar Martins Marques ◽  
Ricardo Vieira Teles Filho ◽  
Paulo Sergio Sucasas Costa
Keyword(s):  
Drug Resistance ◽  
Reverse Transcriptase ◽  
Children And Adolescents ◽  
Resistance Mutations ◽  
Central Brazil ◽  
Antiretroviral Drug Resistance ◽  
Drug Resistance Mutations ◽  
Antiretroviral Drug ◽  
Hiv 1

Antiretroviral drug-resistance mutations compromise the successful treatment of children and adolescents infected with human immunodeficiency virus type 1 (HIV-1). We describe the clinical, virological, and immunological follow-up of a cohort of children and adolescents perinatally infected with HIV-1 treated at Hospital Estadual de Doenças Tropicais Dr. Anuar Auad – HDT, in Central Brazil, after therapeutic failure related to drug resistance mutations.We analyzed the results of the genotypic test (protease codons 1–99 and reverse transcriptase codons 1–325) performed from 2003 to 2015. The ARV susceptibility profile was analyzed according to Stanford HIV drug resistance database. A total of 65 patients (median age of 10 years; range, 18 m–18 y) with therapeutic failure (after a median of 55 months of follow up; range, 9 m–13 y) and plasma levels of HIV-1 RNA greater than 1,000 copies/mL which were included and demonstrated mutations in: nucleoside reverse transcriptase inhibitors (NRTIs), 98.5%; non nucleoside reverse transcriptase inhibitors (NNRTIs), 75.4%; and protease inhibitors (PI), 44.6%. The most frequent NRTI mutations were found in codon T215 (83.1%) with a predominance of T215Y (56.9%), followed by M184V (69.3%). In the NNRTI class, mutations K103N (36.9%) and 190A (23.1%) were predominant, and, in the protease, mutations 54VL (35.4%) and 82ASTL (32.3%) were found in approximately the same proportion, with a predominance of the M54V mutation. These results demonstrate the high levels of resistance to different classes of antiretrovirals in HIV-infected children and adolescents and the importance of genotypic resistance tests in this population.KEY WORDS: HIV; drug resistance; genotypes; child; adolescent.

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