The relationship between genotypic sensitivity score and treatment outcomes in late stage HIV disease after supervised HAART

2009 ◽  
Vol 81 (8) ◽  
pp. 1323-1335 ◽  
Author(s):  
Delivette Castor ◽  
David Vlahov ◽  
Donald R. Hoover ◽  
Alan Berkman ◽  
Ying Feng Wu ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Late Stage ◽  
Hiv Disease ◽  
Sensitivity Score ◽  
Genotypic Sensitivity Score ◽  
The Relationship

scholarly journals Evaluation of the Genotypic Prediction of HIV-1 Coreceptor Use versus a Phenotypic Assay and Correlation with the Virological Response to Maraviroc: the ANRS GenoTropism Study

2010 ◽  
Vol 54 (8) ◽  
pp. 3335-3340 ◽  
Author(s):  
Patricia Recordon-Pinson ◽  
Cathia Soulié ◽  
Philippe Flandre ◽  
Diane Descamps ◽  
Mouna Lazrek ◽  
...  
Keyword(s):  
Virological Response ◽  
False Positive Rate ◽  
Baseline Viral Load ◽  
Phenotypic Assay ◽  
Sensitivity Score ◽  
Positive Rate ◽  
Set Up ◽  
Genotypic Sensitivity Score ◽  
The Relationship ◽  
Hiv 1

ABSTRACT Genotypic algorithms for prediction of HIV-1 coreceptor usage need to be evaluated in a clinical setting. We aimed at studying (i) the correlation of genotypic prediction of coreceptor use in comparison with a phenotypic assay and (ii) the relationship between genotypic prediction of coreceptor use at baseline and the virological response (VR) to a therapy including maraviroc (MVC). Antiretroviral-experienced patients were included in the MVC Expanded Access Program if they had an R5 screening result with Trofile (Monogram Biosciences). V3 loop sequences were determined at screening, and coreceptor use was predicted using 13 genotypic algorithms or combinations of algorithms. Genotypic predictions were compared to Trofile; dual or mixed (D/M) variants were considered as X4 variants. Both genotypic and phenotypic results were obtained for 189 patients at screening, with 54 isolates scored as X4 or D/M and 135 scored as R5 with Trofile. The highest sensitivity (59.3%) for detection of X4 was obtained with the Geno2pheno algorithm, with a false-positive rate set up at 10% (Geno2pheno10). In the 112 patients receiving MVC, a plasma viral RNA load of <50 copies/ml was obtained in 68% of cases at month 6. In multivariate analysis, the prediction of the X4 genotype at baseline with the Geno2pheno10 algorithm including baseline viral load and CD4 nadir was independently associated with a worse VR at months 1 and 3. The baseline weighted genotypic sensitivity score was associated with VR at month 6. There were strong arguments in favor of using genotypic coreceptor use assays for determining which patients would respond to CCR5 antagonist.

Thermal Analysis of Curing Process of Epoxy Prepreg

2001 ◽  
Author(s):  
Liangfeng Sun ◽  
Arthur M. Sterling ◽  
Su-Seng Pang ◽  
Ioan I. Negulescu ◽  
Michael A. Stubblefield
Keyword(s):  
Late Stage ◽  
Curing Process ◽  
Cure Rate ◽  
Degree Of Cure ◽  
Cure Reaction ◽  
Modified Model ◽  
Isothermal Cure ◽  
Cure Time ◽  
Temperature Ranges ◽  
The Relationship

Abstract The curing process of epoxy prepreg was studied by means of Differential Scanning Calorimeter. The dynamic, isothermal, and combinations of dynamic and isothermal measurements were done over selected temperature ranges and isothermal cure temperatures. The heats of reaction for dynamic and isothermal cure were determined. The results show that the heat of isothermal-cure reaction increased with the increment of temperature. The degree of cure was calculated from the heat of isothermal-cure reaction. The complete cure reaction could be achieved at 220 °C within the very short cure time. The changes of cure rate with time were given for the studied isothermal cure temperatures. To simulate the relationship between the cure rate and degree of cure, the autocatalytic model was used and the four parameters were calculated. Except in the late stage of cure reaction, the model agrees well with the experimental data, especially at high temperatures. To account for the effect of diffusion on the cure rate, a diffusion factor was introduced into the model. The modified model greatly improved the predicated data at the late stage of cure reaction.

Assessment of treatment outcomes in hyperthyroid cats treated with an orally administered fixed dose of radioiodine

2019 ◽  
Vol 22 (8) ◽  
pp. 744-752 ◽  
Author(s):  
Lucia Yu ◽  
Lauren Lacorcia ◽  
Sue Finch ◽  
Thurid Johnstone
Keyword(s):  
Treatment Outcomes ◽  
Retrospective Cohort ◽  
Reference Interval ◽  
Fixed Dose ◽  
Clinicopathological Parameters ◽  
Upper Limit ◽  
Before And After ◽  
Total Thyroxine ◽  
The Difference ◽  
The Relationship

Objectives The aims of this study were to describe the treatment outcomes following oral administration of a fixed dose (138 MBq; 3.7 mCi) of radioiodine in hyperthyroid cats and to examine the correlation between total thyroxine (TT4) concentrations before and after treatment. Methods This was a retrospective cohort study that documented the TT4 concentration and clinicopathological parameters at the time of diagnosis and after treatment. Logistic regression was used to assess the relationship between TT4 concentrations before and after treatment. The difference in pre- and post-treatment variables between cats that had TT4 concentrations below or within the reference interval (RI) was compared by the Mann–Whitney U-test. Results Of 161 cats, 133 (82.6%) cats had TT4 concentrations within the RI, four (2.5%) cats had TT4 concentrations above the RI and 24 (14.9%) cats had TT4 concentrations below the RI after treatment. The severity of hyperthyroidism at diagnosis, as measured by the percentage of TT4 elevation above the upper limit of the RI, had no impact on the odds of cats having low TT4 concentrations after treatment (odds ratio 1.00; 95% confidence interval 0.96–1.05; P = 0.828). Conclusions and relevance When using an orally administered fixed dose of radioiodine for the treatment of feline hyperthyroidism, TT4 concentrations at diagnosis cannot be used to predict TT4 concentrations after treatment. The proportion of cats with TT4 concentrations below the lower limit of the RI after treatment was 14.9%. Further work is required to optimise oral radioiodine dosing to achieve maximal euthyroid outcomes.

The relationship between the Shang and the ethnic groups on the Northern Frontiers as reflected in the northern-style bronzes unearthed in Yinxu Site

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Fenghan Zhu
Keyword(s):  
Phase I ◽  
Ethnic Groups ◽  
Phase Ii ◽  
Late Stage ◽  
Mountainous Areas ◽  
Eurasian Steppe ◽  
The People ◽  
Frontier Zone ◽  
The Relationship ◽  
Northern Frontier

AbstractThrough an analysis of oracle bone inscriptions relating to attacks on the northern and western borders of the Shang Kingdom by various ethnic groups living in the Northern Frontier Zone, this paper suggests that the members of northern chiefdoms such as the Qiong Fang, Tu Fang, or Fang Fang mainly lived in the mountainous areas of present-day western and northwestern Shanxi, northeastern Shaanxi, and northern Hebei Provinces. The paper analyzes the characteristics of northern frontier-style bronzes unearthed from this region and suggests to which cultures they may have belonged. Based on these suggestions and analyses, this paper discusses the northern-style bronzes unearthed from offering pits, sacrificial pits and tombs at the Yinxu Site and reveals that the northern-style bronzes frequently seen at Yinxu, especially the ones dating to the late stage of Phase I and Phase II of Yinxu Period (i.e., those dating to the reigns of Kings Wu Ding and Zu Jia), are a sign of frequent warfare between the Shang people and the ethnic groups inhabiting the Northern Frontier Zone, warfare having been the main form of the contact between them. Moreover, this paper discusses the significance of the communication of the Shang with these northern ethnic groups for establishing exchange between the Shang and the people in the Eurasian Steppe.

Histology and stage at presentation among patients with rare pancreatic tumors: An exploratory analysis of the SEER database.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15774-e15774
Author(s):  
Jay Subramoney ◽  
David J. Delgado ◽  
Victoria Nguyen ◽  
Rachel Gray Denneny ◽  
Brandon George ◽  
...  
Keyword(s):  
Late Stage ◽  
Ductal Carcinoma ◽  
Multivariable Analysis ◽  
The United States ◽  
Pancreatic Tumors ◽  
Mucinous Histology ◽  
Pancreatic Cancers ◽  
Initial Stage ◽  
Clinical Interest ◽  
The Relationship

e15774 Background: Rare pancreatic tumors account for approximately 15% of all pancreatic cancers (PCs) and 8,300 new cases diagnosed within the United States annually, while 85% of PCs diagnosed are classified as adenocarcinomas. Comparatively little research exists to analyze differences in diagnosis between rare PCs and the more common adenocarcinoma given greater clinical interest in the latter. The purpose of this study was to analyze the relationship between PC histology and stage at presentation with a focus on rare histologies. Methods: This study employed a retrospective cohort model using the NCI’s Surveillance, Epidemiology, and End Results (SEER) 1990-2015 database. We included patients diagnosed with PC aged 18+, with the comparator group being patients diagnosed with adenocarcinoma, and “rare” tumors defined as one of the following histologies: ductal, carcinoid, mucinous adenocarcinoma, and undetermined neoplasm. Stage was dichotomized (locoregional versus distant). Multivariable logistic regression was used to describe the association between tumor histology with initial stage at diagnosis, controlling for patient and tumor characteristics. Results: 90,764 PC patients were analyzed: 66.3% adenocarcinoma, 9.6% ductal carcinomas, 4.5% carcinoid, 3.8% mucinous, and 15.8% undetermined neoplasm. 54.7% of all cases were distantly metastasized at diagnosis. In multivariable analysis, pancreatic cancer patients with mucinous histology had greater odds of presenting at late-stage compared to those with adenocarcinoma: OR = 1.41, 95% CI = [1.31, 1.52]. Carcinoid and undetermined neoplasm odds for late stage presentation were not significant compared to adenocarcinoma: OR = 0.99, 95% CI = [0.92, 1.07] and OR = 1.01, 95% Cl = [0.97, 1.05] respectively. Ductal carcinoma was less likely than adenocarcinoma to present with late stage: OR = 0.38, CI = [0.36, 0.40]. Conclusions: We observed that mucinous histology had greater odds of late-stage diagnosis compared to those with adenocarcinoma. Patients with ductal carcinoma was less likely than those with adenocarcinoma to present with late stage. Further investigation is needed to explore the reasons for these differences.

The relationship between mental health disorders and treatment outcomes among adults who stutter

2009 ◽  
Vol 34 (1) ◽  
pp. 29-43 ◽  
Author(s):  
Lisa Iverach ◽  
Mark Jones ◽  
Sue O’Brian ◽  
Susan Block ◽  
Michelle Lincoln ◽  
...  
Keyword(s):  
Mental Health ◽  
Treatment Outcomes ◽  
Mental Health Disorders ◽  
Health Disorders ◽  
Adults Who Stutter ◽  
The Relationship

Correlation Between Age and Tendon Strength in Supraspinatus Tendon With Full-Thickness Tears

2013 ◽  
Author(s):  
R. Matthew Miller ◽  
Daisuke Araki ◽  
Yoshimasa Fujimaki ◽  
Volker Musahl ◽  
Richard E. Debski
Keyword(s):  
Rotator Cuff ◽  
Treatment Outcomes ◽  
Clinical Problem ◽  
Supraspinatus Tendon ◽  
Fatty Degeneration ◽  
Rotator Cuff Tears ◽  
Full Thickness ◽  
Insufficient Information ◽  
Poor Treatment ◽  
The Relationship

Degenerative tears of the rotator cuff tendons are a significant clinical problem, with an incidence of more than 30% in asymptomatic persons over the age of 60 [1]. As the population continues to age, the incidence of partial and full-thickness rotator cuff tears continues to increase [2], with previous studies finding that greater age also correlates with worse surgical outcomes and increased fatty degeneration in the tissue [3]. Although the relationship between age, rotator cuff injury, and poor treatment outcomes has been previously established, insufficient information exists on the biological and mechanical changes in the tissue due to aging.

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