Human leukocyte antigen-DRB1*1101 correlates with less severe hepatitis in Taiwanese male carriers of hepatitis B virus

2009 ◽  
Vol 81 (4) ◽  
pp. 588-593 ◽  
Author(s):  
Yi-Wen Huang ◽  
Chung-Yi Hu ◽  
Chi-Lin Chen ◽  
Ya-Tang Liao ◽  
Chun-Jen Liu ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Severe Hepatitis ◽  
Leukocyte Antigen ◽  
B Virus ◽  
Male Carriers

scholarly journals Hepatitis B infection outcome is associated with novel human leukocyte antigen variants in Ghanaian cohort

2020 ◽  
Vol 245 (9) ◽  
pp. 815-822
Author(s):  
Kwesi Z Tandoh ◽  
Kwadwo A Kusi ◽  
Timothy N Archampong ◽  
Isaac Boamah ◽  
Osbourne Quaye
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
P Value ◽  
Hepatitis B Infection ◽  
Virus Persistence ◽  
Hla Alleles ◽  
Leukocyte Antigen ◽  
B Virus

Chronic hepatitis B infection is an important medical problem in sub-Saharan Africa. With increasing concerns of dwindling access to needed care, increasing cost of treatment, and rising prevalence of dire outcomes like liver cirrhosis and hepatocellular cancer, the need to determine the genetic associations underpinning hepatitis B virus persistence or clearance in a population comes to the fore. Genetic association studies have suggested a variation in human leukocyte antigen alleles associated with hepatitis B virus outcome along geo-ethnic lines. We investigated the association of human leukocyte antigen alleles to hepatitis B virus outcome against this backdrop. We used targeted next generation sequencing to type the human leukocyte antigen class I and II alleles of 173 study participants. These comprised of 92 cases with chronic hepatitis B infection and 81 healthy controls with serological evidence of naturally cleared hepatitis B virus infection. We have identified human leukocyte antigen alleles associated with hepatitis B virus clearance and persistence for the first time in a Ghanaian population. The class 1 allele C*16:01 (odds ratio (OR) = 3.4, confidence interval (CI) = 1.6–7.0, P-value = 0.01) was associated with hepatitis B virus persistence. Four class I alleles and one class II allele: A*34:02 (OR = 0.1, CI = 0.04–0.2, P-value = 3.4e-05), A*74:01 (OR = 0.3, CI = 0.2–0.7, P-value = 0.0135), B*13:02 (OR = 0.04, CI = 0.01–0.2, P-value = 0.000172), C*08:04 (OR = 0.06, CI = 0.01–0.2, P-value = 7.83e-05), and DRB1*08:04 (OR = 0.2, CI = 0.03–0.27, P-value = 0.000252) were associated with hepatitis B virus clearance. Our data show that previously reported human leukocyte antigen alleles associations to hepatitis B virus outcome are not found in this Ghanaian study. This study has therefore identified human leukocyte antigen types that are associated with either hepatitis B virus persistence or clearance and highlights the importance of geo-ethnic pivoted studies in determining the genetic associations to acute hepatitis B virus infection outcome. Impact statement Genetic association studies can determine the effect size of gene loci on disease outcomes. In the arena of HBV infections, HLA alleles that associate with HBV outcomes can be used in clinical management decisions. This potential translational utility can shape the future management of HBV infections by identifying at-risk individuals and tailoring medical interventions accordingly. This precision medicine motif is currently only a nascent idea. However, it has stakes that may well override the current “wait and see” approach of clinical management of HBV infections. Here, we have identified HLA alleles associated with HBV outcome in a Ghanaian cohort. Our findings support the motif that HLA alleles associate with HBV outcome along geo-ethnic lines. This buttresses the need for further population pivoted studies. In the long term, our findings add to efforts towards the development of an HLA molecular-based algorithm for predicting HBV infection outcomes.

scholarly journals The Influence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome

2012 ◽  
Vol 12 (5) ◽  
pp. 320-325 ◽  
Author(s):  
Amitis Ramezani ◽  
Mohammad Banifazl ◽  
Setareh Mamishi ◽  
Masoomeh Sofian ◽  
Ali Eslamifar ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Leukocyte Antigen ◽  
Gene Polymorphisms ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
B Virus

scholarly journals Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development

Hepatology ◽  
2012 ◽  
Vol 55 (5) ◽  
pp. 1426-1431 ◽  
Author(s):  
Lingmin Hu ◽  
Xiangjun Zhai ◽  
Jibin Liu ◽  
Minjie Chu ◽  
Shandong Pan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Leukocyte Antigen ◽  
Genetic Variants ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Virus Clearance ◽  
B Virus

scholarly journals The role of human leukocyte antigen tissue groups in hepatitis B virus vaccination in Turkey

2014 ◽  
Vol 47 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Gurkan Mert ◽  
Ali Sengul ◽  
Hanefi Cem Gul ◽  
Ahmet Karakas ◽  
Can Polat Eyigun
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Virus Vaccination ◽  
B Virus

scholarly journals Diagnostic and prognostic biomarkers of Human Leukocyte Antigen complex for hepatitis B virus-related hepatocellular carcinoma

2019 ◽  
Vol 10 (21) ◽  
pp. 5173-5190
Author(s):  
Xiang-Kun Wang ◽  
Xi-Wen Liao ◽  
Cheng-Kun Yang ◽  
Ting-Dong Yu ◽  
Zheng-Qian Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Prognostic Biomarkers ◽  
Leukocyte Antigen ◽  
B Virus ◽  
Antigen Complex
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