scholarly journals Trends in drug resistance mutations in antiretroviral-naïve intravenous drug users of Rio de Janeiro

2006 ◽  
Vol 78 (6) ◽  
pp. 764-769 ◽  
Author(s):  
Sylvia Lopes Maia Teixeira ◽  
Francisco Inácio Bastos ◽  
Mariana A. Hacker ◽  
Monick Lindenmeyer Guimarães ◽  
Mariza Gonçalves Morgado
Keyword(s):  
Drug Resistance ◽  
Rio De Janeiro ◽  
Drug Users ◽  
Intravenous Drug ◽  
Intravenous Drug Users ◽  
Resistance Mutations ◽  
Drug Resistance Mutations

Diversity of HIV Type 1 and Drug Resistance Mutations Among Injecting Drug Users in Kenya

2013 ◽  
Vol 29 (1) ◽  
pp. 187-190 ◽  
Author(s):  
Saida Osman ◽  
Raphael W. Lihana ◽  
Rukia M. Kibaya ◽  
Azumi Ishizaki ◽  
Xiuqiong Bi ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Drug Users ◽  
Injecting Drug Users ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv Type 1

Moderate Prevalence of Transmitted Drug Resistance Mutations Among Antiretroviral-Naive HIV-Infected Pregnant Women in Rio de Janeiro, Brazil

2013 ◽  
Vol 29 (4) ◽  
pp. 681-686 ◽  
Author(s):  
José H. Pilotto ◽  
Beatriz Grinsztejn ◽  
Valdilea G. Veloso ◽  
Luciane S. Velasque ◽  
Ruth K. Friedman ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pregnant Women ◽  
Rio De Janeiro ◽  
Transmitted Drug Resistance ◽  
Resistance Mutations ◽  
Drug Resistance Mutations

scholarly journals Using Molecular Transmission Networks to Reveal the Epidemic of Pretreatment HIV-1 Drug Resistance in Guangxi, China

2021 ◽  
Vol 12 ◽  
Author(s):  
Fei Zhang ◽  
Bingyu Liang ◽  
Xu Liang ◽  
Zhaosen Lin ◽  
Yuan Yang ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Injection Drug Users ◽  
Drug Users ◽  
Resistance Mutations ◽  
Related Factors ◽  
Transmission Networks ◽  
Drug Resistance Mutations ◽  
Two Cities ◽  
Viral Subtypes ◽  
Hiv 1

IntroductionPretreatment drug resistance (PDR) is becoming an obstacle to the success of ART. This study investigated the prevalence of PDR and the transmission clusters (TCs) of drug resistance mutations (DRMs) in two cities where drug abuse used to be high to describe the local HIV-1 transmission dynamics.MethodsPlasma samples were obtained from 1,027 ART-naïve patients in Guangxi. Viral subtypes and DRMs were identified. Transmission network and related factors were also determined.ResultsA total of 1,025 eligible sequences were obtained from Qinzhou (65.8%) and Baise (34.2%) cities. The predominant HIV-1 genotype was CRF08_BC (45.0%), followed by CRF01_AE (40.9%). The overall prevalence of PDR was 8.3%, and resistance to NNRTI was the most common. Putative links with at least one other sequence were found in 543/1,025 (53.0%) sequences, forming 111 clusters (2–143 individuals). The most prevalent shared DRMs included V106I (45.35%), V179D (15.1%), and V179E (15.1%). Clusters related to shared DRMs were more frequent and larger in CRF08_BC. The prevalence of shared DRMs increased with time, while the proportion of PDR gradually decreased. Age > 50 years was associated with clustering. Subtype CRF08_BC was more likely to have DRMs, PDR propagation, and DRM sharing.ConclusionPDR prevalence is moderate in this region. The association between PDR and subtype CRF08_BC suggested that DRMs spreading from injection drug users (IDUs) to heterosexuals (HETs) might be the major source of PDR in this region. Our findings highlight the significance of continuous surveillance of PDR.

No Increase in HIV Drug Resistance Mutations among Injecting Drug Users on Methadone Maintenance Therapy: A Prospective Cohort Study

2020 ◽  
Vol 18 (5) ◽  
pp. 362-372
Author(s):  
Chunyuan Huang ◽  
Li Ye ◽  
Abu S Abdullah ◽  
Bingyu Liang ◽  
Junjun Jiang ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Maintenance Therapy ◽  
Prospective Cohort ◽  
Drug Users ◽  
Methadone Maintenance ◽  
Injecting Drug Users ◽  
Methadone Maintenance Therapy ◽  
Hiv Positive ◽  
Resistance Mutations ◽  
Drug Resistance Mutations

Background: Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear. Objective: To compare the incidence of new DRMs in two population groups: antiretroviraltreatment (ART) HIV-positive IDUs and non-drug users. Methods: A prospective cohort of ART HIV-positive patients including IDUs who received MMT (MMT group) and non-drug users (N-MMT group) was established from April 2016 to December 2017 in Guangxi, China. Results: Of the 80 participants, 43 were in the MMT group and 37 were in the N-MMT group. Compared with the N-MMT group, the HRs of PIs, NRTIs and NNRTIs for new DRMs in the MMT group was 1.55 (95%CI: 0.28-8.64; P = 0.616), 1.51 (95%CI: 0.44-5.20; P = 0.512) and 0.45 (95%CI: 0.15-1.35; P = 0.155), respectively. There was no dose-response relationship between MMT and new DRMs for PIs, NRTIs and NNRTIs (P > 0.05). The new DRM incidence for NRTIs (138.23 per 104 person-months) was higher than for PIs (94.16 per 104 person-months) and NNRTIs (95.41per 104 person-months) in the MMT group, while the new DRM incidence for NNRTIs (208.24 per 104 person-months) was higher than for PIs (44.13 per 104 person-months) and NRTIs (91.78 per 104 person-months) in the N-MMT group. Conclusion: Among ART HIV-positive patients, there is no significant difference in the incidence of new DRMs between IDUs receiving MMT and non-drug users. MMT has little impact on the development of DRMs among IDUs.

scholarly journals Transmitted Drug Resistance Mutations in Antiretroviral-Naïve Injection Drug Users with Chronic HIV-1 Infection in Iran

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126955 ◽  
Author(s):  
Arash Memarnejadian ◽  
Shahoo Menbari ◽  
Seyed Ali Mansouri ◽  
Leila Sadeghi ◽  
Rouhollah Vahabpour ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
Transmitted Drug Resistance ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Hiv 1

scholarly journals HIV-1 Diversity and Drug Resistance Mutations among People Seeking HIV Diagnosis in Voluntary Counseling and Testing Sites in Rio de Janeiro, Brazil

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e87622 ◽  
Author(s):  
Carlos A. Velasco-de-Castro ◽  
Beatriz Grinsztejn ◽  
Valdiléa G. Veloso ◽  
Francisco I. Bastos ◽  
José H. Pilotto ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Rio De Janeiro ◽  
Resistance Mutations ◽  
Hiv Diagnosis ◽  
Voluntary Counseling ◽  
Voluntary Counseling And Testing ◽  
Drug Resistance Mutations ◽  
Counseling And Testing ◽  
Hiv 1
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