scholarly journals Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients

2006 ◽  
Vol 78 (3) ◽  
pp. 408-416 ◽  
Author(s):  
Giuseppe Gerna ◽  
Patrizio Vitulo ◽  
Francesca Rovida ◽  
Daniele Lilleri ◽  
Carlo Pellegrini ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Human Cytomegalovirus ◽  
Lower Respiratory Tract ◽  
Lung Transplant ◽  
Respiratory Tract Infections ◽  
Respiratory Viruses ◽  
Transplant Recipients ◽  
Lower Respiratory Tract Infections ◽  
Lung Transplant Recipients ◽  
Tract Infections

scholarly journals Community-acquired Respiratory Viruses Are a Risk Factor for Chronic Lung Allograft Dysfunction

2018 ◽  
Vol 69 (7) ◽  
pp. 1192-1197 ◽  
Author(s):  
Maddalena Peghin ◽  
Ibai Los-Arcos ◽  
Hans H Hirsch ◽  
Gemma Codina ◽  
Víctor Monforte ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Risk Factors ◽  
Acute Rejection ◽  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Lung Transplant ◽  
Respiratory Viruses ◽  
Transplant Recipients ◽  
Independent Risk Factors ◽  
Lung Transplant Recipients

Abstract Background The relationship between community-acquired respiratory viruses (CARVs) and chronic lung allograft dysfunction (CLAD) in lung transplant recipients is still controversial. Methods We performed a prospective cohort study (2009–2014) in all consecutive adult patients (≥18 years) undergoing lung transplantation in the Hospital Universitari Vall d’Hebron (Barcelona, Spain). We systematically collected nasopharyngeal swabs from asymptomatic patients during seasonal changes, from patients with upper respiratory tract infectious disease, lower respiratory tract infectious disease (LRTID), or acute rejection. Nasopharyngeal swabs were analyzed by multiplex polymerase chain reaction. Primary outcome was to evaluate the potential association of CARVs and development of CLAD. Time-dependent Cox regression models were performed to identify the independent risk factors for CLAD. Results Overall, 98 patients (67 bilateral lung transplant recipients; 63.3% male; mean age, 49.9 years) were included. Mean postoperative follow-up was 3.4 years (interquartile range [IQR], 2.5–4.0 years). Thirty-eight lung transplant recipients (38.8%) developed CLAD, in a median time of 20.4 months (IQR, 12–30.4 months). In time-controlled multivariate analysis, CARV-LRTID (hazard ratio [HR], 3.00 [95% confidence interval {CI}, 1.52–5.91]; P = .002), acute rejection (HR, 2.97 [95% CI, 1.51–5.83]; P = .002), and cytomegalovirus pneumonitis (HR, 3.76 [95% CI, 1.23–11.49]; P = .02) were independent risk factors associated with developing CLAD. Conclusions Lung transplant recipients with CARVs in the lower respiratory tract are at increased risk to develop CLAD.

scholarly journals Respiratory viruses in neonates hospitalized with acute lower respiratory tract infections

2012 ◽  
Vol 55 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Hye Jung Cho ◽  
So-Yeon Shim ◽  
Dong Woo Son ◽  
Yong Han Sun ◽  
Hann Tchah ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Respiratory Viruses ◽  
Lower Respiratory Tract Infections ◽  
Tract Infections
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