Quantitative analysis of human herpesvirus 6 cell tropism

2004 ◽  
Vol 75 (1) ◽  
pp. 76-85 ◽  
Author(s):  
L. De Bolle ◽  
J. Van Loon ◽  
E. De Clercq ◽  
Lieve Naesens
Keyword(s):  
Quantitative Analysis ◽  
Human Herpesvirus ◽  
Cell Tropism ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

Quantitative analysis of human herpesvirus-6 and human cytomegalovirus in blood and saliva from patients with acute leukemia

2014 ◽  
Vol 87 (3) ◽  
pp. 451-460 ◽  
Author(s):  
Faten Nefzi ◽  
Nabil Abid Ben Salem ◽  
Abderrahim Khelif ◽  
Salma Feki ◽  
Mahjoub Aouni ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Acute Leukemia ◽  
Human Cytomegalovirus ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

scholarly journals The U94 Gene of Human Herpesvirus 6: A Narrative Review of Its Role and Potential Functions

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2608
Author(s):  
Elisabetta Caselli ◽  
Maria D’Accolti ◽  
Francesca Caccuri ◽  
Irene Soffritti ◽  
Valentina Gentili ◽  
...  
Keyword(s):  
Natural Infection ◽  
Human Herpesvirus ◽  
Cell Tropism ◽  
Human Herpesvirus 6 ◽  
Cell Level ◽  
Associated Diseases ◽  
Virus Life Cycle ◽  
Genome Homology ◽  
Herpesvirus 6 ◽  
Human Herpesviruses

Human herpesvirus 6 (HHV-6) is a β-herpesvirus that is highly prevalent in the human population. HHV-6 comprises two recognized species (HHV-6A and HHV-6B). Despite different cell tropism and disease association, HHV-6A/B show high genome homology and harbor the conserved U94 gene, which is limited to HHV-6 and absent in all the other human herpesviruses. U94 has key functions in the virus life cycle and associated diseases, having demonstrated or putative roles in virus replication, integration, and reactivation. During natural infection, U94 elicits an immune response, and the prevalence and extent of the anti-U94 response are associated with specific diseases. Notably, U94 can entirely reproduce some virus effects at the cell level, including inhibition of cell migration, induction of cytokines and HLA-G expression, and angiogenesis inhibition, supporting a direct U94 role in the development of HHV-6-associated diseases. Moreover, specific U94 properties, such as the ability to modulate angiogenesis pathways, have been exploited to counteract cancer development. Here, we review the information available on this key HHV-6 gene, highlighting its potential uses.

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