Mode of HCV infection examined by polymorphism of hypervariable region-1 in cases of acute hepatitis C after accidental exposure to blood-borne pathogens

2004 ◽  
Vol 75 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Tadashi Takeda ◽  
Nobuyuki Tatsumi ◽  
Yuji Nakayama ◽  
Takahiro Yasuda ◽  
Shuhei Nishiguchi ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Hypervariable Region ◽  
Hcv Infection ◽  
Acute Hepatitis C ◽  
Accidental Exposure ◽  
Hypervariable Region 1 ◽  
Accidental Exposure To Blood

Treatment of acute hepatitis C infection with interferon-alfa 2b monotherapy prevents development of chronic HCV infection

2001 ◽  
Vol 120 (5) ◽  
pp. A567-A567 ◽  
Author(s):  
E JAECKEL ◽  
M CORNBERG ◽  
T SANTANTONIO ◽  
J MAYER ◽  
H WEDEMEYER ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Interferon Alfa ◽  
Hcv Infection ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

scholarly journals Testing Strategy To Identify Cases of Acute Hepatitis C Virus (HCV) Infection and To Project HCV Incidence Rates

2007 ◽  
Vol 46 (2) ◽  
pp. 499-506 ◽  
Author(s):  
K. Page-Shafer ◽  
B. L. Pappalardo ◽  
L. H. Tobler ◽  
B. H. Phelps ◽  
B. R. Edlin ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Incidence Rates ◽  
Hcv Infection ◽  
Acute Hepatitis C ◽  
Testing Strategy

scholarly journals Chronic HCV - infection in the Kirov region: Dynamics of indices of disease in adults in 1995-2010

2013 ◽  
Vol 18 (2) ◽  
pp. 33-36
Author(s):  
S. V Baramzina
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Chronic Hepatitis C ◽  
Hcv Infection ◽  
Acute Hepatitis C ◽  
Chronic Hcv Infection ◽  
Chronic Hcv ◽  
The Given ◽  
Epidemiological Situation

In the given article the analysis of an epidemiological situation concerning chronic forms of HCV infections in adults in the Kirov region in 1995-2010 is presented. In the region during analyzed period stable trend to the elevation of incidence of chronic hepatitis C and a slight decrease in the number of "carriers" of HCV on the background of steadily low indices of the occurrence of acute hepatitis C have been fixed. There are also presented the results of genotyping of HCV-virus in 730 patients with chronic hepatitis C treated at the Kirov Region infectious hospital and polyclinics in Kirov with the dominance of HCV subtypes 1b and 3a .

scholarly journals Acute Hepatitis C Virus Structural Gene Sequences as Predictors of Persistent Viremia: Hypervariable Region 1 as a Decoy

1999 ◽  
Vol 73 (4) ◽  
pp. 2938-2946 ◽  
Author(s):  
Stuart C. Ray ◽  
Yu-Ming Wang ◽  
Oliver Laeyendecker ◽  
John R. Ticehurst ◽  
Stephen A. Villano ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Selective Pressure ◽  
Hypervariable Region ◽  
Amino Acid Sequences ◽  
Heteroduplex Analysis ◽  
Acute Hepatitis C ◽  
Hypervariable Region 1 ◽  
Persistent Viremia ◽  
Quasispecies Complexity

ABSTRACT We hypothesized that hepatitis C virus (HCV) persistence is related to the sequence variability of putative envelope genes. This hypothesis was tested by characterizing quasispecies in specimens collected every six months from a cohort of acutely HCV-infected subjects (mean duration of specimen collection, 72 months after seroconversion). We evaluated 5 individuals who spontaneously cleared viremia and 10 individuals with persistent viremia by cloning 33 1-kb amplicons that spanned E1 and the 5′ half of E2, including hypervariable region 1 (HVR1). To assess the quasispecies complexity and to detect variants for sequencing, the first PCR-positive sample was examined by using a previously described method that combines heteroduplex analysis and analysis of single-stranded conformational polymorphisms. The ratio of nonsynonymous to synonymous substitutions (dN/dS ) within each sample was evaluated as an indicator of relative selective pressure. Amino acid sequences were analyzed for signature patterns, glycosylation signals, and charge. Quasispecies complexity was higher and E1dN/dS ratios (selective pressure) were lower in those with persistent viremia; the association with persistence was strengthened by the presence of a combination of both characteristics. In contrast, a trend toward higher HVR1dN/dS ratios was detected among those with persistent viremia. We did not detect any such association for factors that may affect complexity such as serum HCV RNA concentration. HVR1 had a lower positive charge in subjects with persistent viremia, although no consistent motifs were detected. Our data suggest that HCV persistence is associated with a complex quasispecies and immune response to HVR1.

Acute Hepatitis C: Clinical Aspects, Diagnosis, and Outcome of Acute HCV Infection

2008 ◽  
Vol 14 (17) ◽  
pp. 1661-1665 ◽  
Author(s):  
P. Fabris ◽  
V. Fleming ◽  
M. Giordani ◽  
E. Barnes
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Hcv Infection ◽  
Clinical Aspects ◽  
Acute Hepatitis C ◽  
Acute Hcv ◽  
Acute Hcv Infection

The serology of hepatitis C virus (HCV) infection: antibody crossreaction in the hypervariable region 1

1995 ◽  
Vol 140 (10) ◽  
pp. 1705-1713 ◽  
Author(s):  
M. da Silva Cardoso ◽  
K. Siemoneit ◽  
V. Nemecek ◽  
S. Epple ◽  
K. Koerner ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hypervariable Region ◽  
Hcv Infection ◽  
Hypervariable Region 1
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