Major histocompatibility complex class-I presentation impaired in transgenic mice expressing hepatitis C virus structural proteins during dendritic cell maturation

2004 ◽  
Vol 74 (2) ◽  
pp. 253-261 ◽  
Author(s):  
Yoichi Hiasa ◽  
Hidemi Takahashi ◽  
Masumi Shimizu ◽  
Hideko Nuriya ◽  
Kyoko Tsukiyama-Kohara ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Dendritic Cell ◽  
Transgenic Mice ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Structural Proteins ◽  
Complex Class ◽  
Histocompatibility Complex

Hepatitis C virus structural proteins do not prevent human dendritic cell maturation

2008 ◽  
Vol 32 (1) ◽  
pp. 59-68 ◽  
Author(s):  
C. Thumann ◽  
E. Schvoerer ◽  
J.-D. Abraham ◽  
A. Bohbot ◽  
F. Stoll-Keller ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Dendritic Cell ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Structural Proteins ◽  
Human Dendritic Cell

scholarly journals CD1 and Major Histocompatibility Complex II Molecules Follow a Different Course during Dendritic Cell Maturation

2003 ◽  
Vol 14 (8) ◽  
pp. 3378-3388 ◽  
Author(s):  
Nicole N. van der Wel ◽  
Masahiko Sugita ◽  
Donna M. Fluitsma ◽  
Xaiochun Cao ◽  
Gerty Schreibelt ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Major Histocompatibility Complex ◽  
Dendritic Cell ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Major Histocompatibility ◽  
Mhc Molecules ◽  
Histocompatibility Complex

The maturation of dendritic cells is accompanied by the redistribution of major histocompatibility complex (MHC) class II molecules from the lysosomal MHC class II compartment to the plasma membrane to mediate presentation of peptide antigens. Besides MHC molecules, dendritic cells also express CD1 molecules that mediate presentation of lipid antigens. Herein, we show that in human monocyte-derived dendritic cells, unlike MHC class II, the steady-state distribution of lysosomal CD1b and CD1c isoforms was unperturbed in response to lipopolysaccharide-induced maturation. However, the lysosomes in these cells underwent a dramatic reorganization into electron dense tubules with altered lysosomal protein composition. These structures matured into novel and morphologically unique compartments, here termed mature dendritic cell lysosomes (MDL). Furthermore, we show that upon activation mature dendritic cells do not lose their ability of efficient clathrin-mediated endocytosis as demonstrated for CD1b and transferrin receptor molecules. Thus, the constitutive endocytosis of CD1b molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation.

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