HIV therapy after treatment interruption in patients with multiple failure and more than 200 CD4+T lymphocyte count

2004 ◽  
Vol 74 (1) ◽  
pp. 8-15 ◽  
Author(s):  
Acil Jaafar ◽  
Patrice Massip ◽  
Karine Sandres-Sauné ◽  
Corinne Souyris ◽  
Christophe Pasquier ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Count ◽  
Treatment Interruption ◽  
Hiv Therapy

scholarly journals Viral coinfection in the oral cavity of HIV-infected children: relation among HIV viral load, CD4+T lymphocyte count and detection of EBV, CMV and HSV

2005 ◽  
Vol 19 (3) ◽  
pp. 228-234 ◽  
Author(s):  
Liliane Janete Grando ◽  
Denise Cantarelli Machado ◽  
Silvia Spitzer ◽  
Sharon Nachman ◽  
Fred Ferguson ◽  
...  
Keyword(s):  
New York ◽  
Viral Load ◽  
Oral Cavity ◽  
T Lymphocyte ◽  
Lymphocyte Count ◽  
Viral Infections ◽  
University Hospital ◽  
State University ◽  
Hiv Viral Load ◽  
Viral Coinfection

Viral coinfection in the oral cavity associated to HIV infection was evaluated in 180 children from birth to 13 years of age of both sexes. The oral examinations were performed at the Pediatric AIDS Outpatient Clinic, São Lucas Hospital and Clinic Hospital, both in Porto Alegre, Brazil and at the School of Dental Medicine, University Hospital Center, State University of New York at Stony Brook, USA. The aim of this study was to identify the presence of viral infections in the oral cavity. PCR technique was used to determine opportunistic viral infections caused by CMV, EBV, and HSV in mucosal swabs. A high frequency of viral infection was detected in the oral cavity of HIV-infected children determined by the PCR technique. HIV-infected children with viruses had a favorable CD4+T lymphocyte count and unfavorable viral load.

scholarly journals Risk factors and clinical features of deterioration in COVID-19 patients in Zhejiang, China: a single- centre, retrospective study

2020 ◽  
Author(s):  
Ping Yi ◽  
Xiang Yang ◽  
Cheng Ding ◽  
Yanfei Chen ◽  
Kaijin Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
T Lymphocyte ◽  
Lymphocyte Count ◽  
Clinical Characteristics ◽  
B Lymphocyte ◽  
Blood Cell Count ◽  
Single Centre ◽  
Multiple Factors ◽  
Independent Risk Factors ◽  
Severity Of The Disease

Abstract BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection swept through Wuhan and spread across China and overseas beginning in December 2019. To identify predictors associated with disease progression, we evaluated clinical risk factors for exacerbation of SARS-CoV-2 infection.MethodsA retrospective analysis was used for PCR-confirmed COVID-19 (coronavirus disease 2019)-diagnosed hospitalized cases between January 19, 2020, and February 19, 2020, in Zhejiang, China. We systematically analysed the clinical characteristics of the patients and predictors of clinical deterioration.ResultsOne hundred patients with COVID-19, with a median age of 54 years, were included. Among them, 49 patients (49%) had severe and critical disease. Age ([36-58] vs [51-70], P=0.0001); sex (49% vs 77.6%, P=0.0031); Body Mass Index (BMI ) ([21.53-25.51] vs [23.28-27.01], P=0.0339); hypertension (17.6% vs 57.1%, P<0.0001); IL-6 ([6.42-30.46] vs [16.2-81.71], P=0.0001); IL-10 ([2.16-5.82] vs [4.35-9.63], P<0.0001); T lymphocyte count ([305- 1178] vs [167.5-440], P=0.0001); B lymphocyte count ([91-213] vs [54.5-163.5], P=0.0001); white blood cell count ([3.9-7.6] vs [5.5-13.6], P=0.0002); D2 dimer ([172-836] vs [408-953], P=0.005), PCT ([0.03-0.07] vs [0.04-0.15], P=0.0039); CRP ([3.8-27.9] vs [17.3-58.9], P<0.0001); AST ([16, 29] vs [18, 42], P=0.0484); artificial liver therapy (2% vs 16.3%, P=0.0148); and glucocorticoid therapy (64.7% vs 98%, P<0.0001) were associated with the severity of the disease. Age and weight were independent risk factors for disease severity.ConclusionDeterioration among COVID-19-infected patients occurred rapidly after hospital admission. In our cohort, we found that multiple factors were associated with the severity of COVID19. Early detection and monitoring of these indicators may reduce the progression of the disease. Removing these factors may halt the progression of the disease. In addition, Oxygen support, early treatment with low doses of glucocorticoids and liver therapy, when necessary, may help reduce mortality in critically ill patients.

scholarly journals Thyroid dysfunction in human immunodeficiency virus-infected children and its correlation with CD4+T lymphocyte count

2015 ◽  
Vol 19 (2) ◽  
pp. 272 ◽  
Author(s):  
Salam Ranabir ◽  
Satyakumar Thongam ◽  
Sunibala Keithelakpam ◽  
TombaY Singh ◽  
RanbirL Singh ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocyte ◽  
Lymphocyte Count ◽  
Thyroid Dysfunction ◽  
Immunodeficiency Virus

EFFECT OF IMMUNOMODULATORY HERBAL MEDICINAL PREPARATIONS ON CD4 + LYMPHOCYTE COUNT AND TOTAL VIRAL LOAD IN HIV-INFECTED INDIVIDUALS

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (07) ◽  
pp. 42-48
Author(s):  
S. T. Tharakan ◽  
◽  
G Kuttan ◽  
R. Kuttan ◽  
M. Kesavan ◽  
...  
Keyword(s):  
Renal Function ◽  
Body Weight ◽  
Viral Load ◽  
Hiv Infection ◽  
T Lymphocyte ◽  
Lymphocyte Count ◽  
Clinical Status ◽  
Hiv Patients ◽  
Herbal Formulation ◽  
Hematological Analysis

This study was carried out to determine the effect of herbal medication on the clinical status of HIV infected persons especially on their CD4+ T lymphocyte count and viral load. The toxicity of the medication was also studied. 25 HIV positive individuals were taken for the study. They were treated with a herbal formulation developed in our centre, for one year. Patients were evaluated for their clinical status every month and CD4+ T lymphocyte and viral load every six months. Other parameters assessed were body weight, hematological analysis and hepatic and renal function tests. Body weight was found to be increased in 20 patients out of 25 who have undergone treatment. CD4+T lymphocyte count was increased in 15 patients and viral load was decreased in 20 patients. In six patients viral load was undetectable range. Administration of these medications significantly reduced, elevated interferon-? and tumor necrosis factor in HIV patients. Medication did not produce any toxicity in HIV patients, as it did not show any significant change in hepatic function, renal function and haematology. Administration of herbal preparation was found to reduce clinical symptoms produced by HIV infection. This herbal formulation was found useful therapeutically for the management of HIV infection and did not produce any toxicity.

scholarly journals Prediction of CD4 T-Lymphocyte Count Using WHO Clinical Staging among ART-Naïve HIV-Infected Adolescents and Adults in Northern Ethiopia: A Retrospective Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Abraham Desta Aregay ◽  
Kibriti Mehari Kidane ◽  
Asfawosen Berhe Aregay ◽  
Kiros Ajemu Fenta ◽  
Ataklti Gebretsadik Woldegebriel ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocyte ◽  
Lymphocyte Count ◽  
Cd4 Count ◽  
Cd4 T Cell ◽  
Clinical Staging ◽  
Northern Ethiopia ◽  
Immunological Status ◽  
Cell Counts ◽  
Adolescents And Adults

Background. WHO clinical staging has long been used to assess the immunological status of HIV-infected patients at initiation of antiretroviral therapy and during treatment follow-up. In setups where CD4 count determination is not readily available, WHO clinical staging is a viable option. However, correlation between CD4 count and WHO clinical staging is not known in an Ethiopian setting, and hence, the main aim of this study was to assess predictability of CD4 T-lymphocyte count using WHO clinical staging among ART-naïve HIV-infected adolescents and adults in northern Ethiopia. Methods. A retrospective cross-sectional study was done in the Tigray Region, Ethiopia, from April 2015 to January 2019 from a secondary database of 19525 HIV-infected patients on antiretroviral treatment. Analysis was done using STATA-14.0 to estimate the frequencies, mean, and median of CD4 T-cell count in each WHO stages. Sensitivity, specificity, positive predictive value, negative predictive value, kappa test, and correlations were calculated to show the relationships between WHO stages and CD T-cell count. Results. The sensitivity of WHO clinical staging to predict CD4 T-cell counts of <200 cells/μl was 94.17% with a specificity of 3.62%. The PPV was 49.03%, and the NPV was 3.62%. The sensitivity of WHO clinical staging to predict CD4 T-cell counts of <350 cells/μl was 94.75% with a specificity of 3.00%. The PPV was 75.81%, and the NPV was 15.09%. Similarly, the sensitivity of WHO clinical staging to predict CD4 T-cell counts of <500 cells/μl was 95.03% with a specificity of 2.73% and the PPV and NPV were 88.32% and 6.62%, respectively. The kappa agreement of WHO clinical stages was also insignificant when compared with the disaggregated CD4 counts in different categories. The correlation of WHO clinical staging was inversely associated with the CD4 count, and the magnitude of the correlation was 5.22%. Conclusions. The WHO clinical staging had high sensitivity but low specificity in predicting patients with CD4 count <200 cells/μl, <350 cells/μl, and <500 cells/μl. There was poor correlation and agreement between CD4 T-lymphocyte count and WHO clinical staging. Therefore, WHO clinical staging alone may not provide accurate information on the immunological status of patients, and hence, it is better to use the CDC definition rather than the WHO clinical definition.

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