Oxidative injury to endothelial cells due to Epstein-Barr virus-induced autoantibodies against manganese superoxide dismutase

2003 ◽  
Vol 71 (3) ◽  
pp. 408-416 ◽  
Author(s):  
Alexander H. Dalpke ◽  
Reiner Thomssen ◽  
Klaus Ritter
Keyword(s):  
Endothelial Cells ◽  
Superoxide Dismutase ◽  
Epstein Barr Virus ◽  
Manganese Superoxide Dismutase ◽  
Oxidative Injury ◽  
Barr Virus ◽  
Manganese Superoxide ◽  
Epstein Barr

scholarly journals Manganese superoxide dismutase as a target of autoantibodies in acute Epstein-Barr virus infection.

1994 ◽  
Vol 180 (5) ◽  
pp. 1995-1998 ◽  
Author(s):  
K Ritter ◽  
R J Kühl ◽  
F Semrau ◽  
H Eiffert ◽  
H D Kratzin ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Epstein Barr Virus ◽  
Manganese Superoxide Dismutase ◽  
Clinical Symptoms ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Ebv Infection ◽  
Manganese Superoxide ◽  
Epstein Barr

Antibodies directed against the autoantigen p26 were detected in sera from 32 patients with acute Epstein-Barr virus (EBV) infection and clinical symptoms of infectious mononucleosis. P26 has now been identified as the enzyme manganese superoxide dismutase (MnSOD) by comparison of the NH2-terminal amino acid sequence. Antibodies against MnSOD belong to the immunoglobulin class M. They are not detectable in sera of patients with other herpesvirus infections. In the 32 patients investigated, the rise and fall of the autoantibodies coincides with the clinical symptoms. In vitro, the autoantibodies were shown to inhibit the dismutation of superoxide radicals by blocking MnSOD. As presented in the discussion this effect may contribute to the pathogenesis of acute EBV infection.

scholarly journals Glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity in patients with diabetes mellitus type 2 infected with Epstein-Barr virus

PLoS ONE ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. e0230374 ◽  
Author(s):  
Jakub Dworzański ◽  
Małgorzata Strycharz-Dudziak ◽  
Ewa Kliszczewska ◽  
Małgorzata Kiełczykowska ◽  
Anna Dworzańska ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Diabetes Mellitus Type 2 ◽  
Epstein Barr Virus ◽  
Sod Activity ◽  
Barr Virus ◽  
Patients With Diabetes ◽  
Epstein Barr

scholarly journals Infection of human endothelial cells with Epstein-Barr virus.

1995 ◽  
Vol 182 (5) ◽  
pp. 1213-1221 ◽  
Author(s):  
K Jones ◽  
C Rivera ◽  
C Sgadari ◽  
J Franklin ◽  
E E Max ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Lines ◽  
Epstein Barr Virus ◽  
Human Umbilical Cord ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Barr Virus ◽  
Negative Cell ◽  
Epstein Barr

Interleukin-6 (IL-6) promotes growth and tumorigenicity of Epstein-Barr virus (EBV)-immortalized B cells, and is abnormally elevated in the serum of solid organ transplant recipients who develop EBV-positive posttransplant lymphoproliferative disease (PTLD), but not in control transplant recipients. Endothelial cells derived from PTLD lesions were found to secrete spontaneously high levels of IL-6 in vitro for up to 4 mo. We examined possible mechanisms for sustained IL-6 production by endothelial cells. Here, we show that EBV can infect endothelial cells in vitro. After 3-4 wk incubation with lethally irradiated EBV-positive, but not EBV-negative cell lines, a proportion of human umbilical cord-derived endothelial cells (HUVECs) expressed in situ the EBV-encoded small RNAs (EBER). Southern blot analysis after polymerase chain reaction showed EBV DNA in HUVEC that had been incubated with lethally irradiated EBV-positive cells, but not in the controls. Exposure of HUVECs to lethally irradiated EBV-positive but not EBV-negative cell lines induced IL-6 production that was sustained for up to 120 d of culture. These studies identify endothelial cells as targets for EBV infection and raise the possibility that this infection may be important in the life cycle and pathology of EBV.

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