Antigenic and genetic variability of human respiratory syncytial viruses (group A) isolated in Uruguay and Argentina: 1993-2001

2003 ◽  
Vol 71 (2) ◽  
pp. 305-312 ◽  
Author(s):  
Sandra Frabasile ◽  
Adriana Delfraro ◽  
Luj�n Facal ◽  
Cristina Videla ◽  
M�nica Galiano ◽  
...  
Keyword(s):  
Genetic Variability ◽  
Group A ◽  
Respiratory Syncytial Viruses

Genetic variability of group A and B human respiratory syncytial viruses isolated from 3 provinces in China

2007 ◽  
Vol 152 (8) ◽  
pp. 1425-1434 ◽  
Author(s):  
Y. Zhang ◽  
W. Xu ◽  
K. Shen ◽  
Z. Xie ◽  
L. Sun ◽  
...  
Keyword(s):  
Genetic Variability ◽  
Group A ◽  
Respiratory Syncytial Viruses

scholarly journals Genetic variability among group A and B respiratory syncytial viruses in Mozambique: identification of a new cluster of group B isolates

2001 ◽  
Vol 82 (1) ◽  
pp. 103-111 ◽  
Author(s):  
Anna Roca ◽  
Mari-Paz Loscertales ◽  
Llorenç Quintó ◽  
Pilar Pérez-Breña ◽  
Neide Vaz ◽  
...  
Keyword(s):  
Genetic Variability ◽  
Protein Gene ◽  
N Protein ◽  
Glycosylation Sites ◽  
Rsv Infection ◽  
Group A ◽  
Respiratory Syncytial Viruses ◽  
Syncytial Virus ◽  
Group B ◽  
Vulnerable Adults

Respiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infection in children and vulnerable adults, but little is known regarding RSV infection in Africa. In this report, a recent RSV outbreak in Mozambique was studied and results showed that 275 of 3192 (8·6%) nasopharyngeal aspirates tested were RSV-positive by ELISA. RSV presents two antigenic groups (A and B) with a high genetic and antigenic variability between and within them. Analysis by a new RFLP assay of RT–PCR amplified N protein gene products showed a higher prevalence of group B RSV than that of group A (85% versus 15%). However, genetic variability of the G protein gene was higher among group A RSV strains. The frequency and pattern of glycosylation sites were also quite different between both groups. In addition, two different phylogenetic clusters of Mozambican viruses were found within each group, but only sequences from cluster B-I were relatively distinct from previously described isolates. The implications of such differences in the antigenic and immunogenic characteristics of each group are discussed.

scholarly journals Genetic Variability in the G Protein Gene of Group A and B Respiratory Syncytial Viruses from India

2006 ◽  
Vol 44 (9) ◽  
pp. 3055-3064 ◽  
Author(s):  
S. Parveen ◽  
W. M. Sullender ◽  
K. Fowler ◽  
E. J. Lefkowitz ◽  
S. K. Kapoor ◽  
...  
Keyword(s):  
Genetic Variability ◽  
G Protein ◽  
Protein Gene ◽  
Group A ◽  
Respiratory Syncytial Viruses

Species delimitation in the Lepraria isidiata-L. santosii group: a population study in the Mediterranean-Macaronesian region

2009 ◽  
Vol 41 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Mauro Tretiach ◽  
Lucia Muggia ◽  
Laurence Baruffo
Keyword(s):  
Phylogenetic Analysis ◽  
Genetic Variability ◽  
Species Delimitation ◽  
Carbonate Rocks ◽  
Morphological Study ◽  
Species Level ◽  
Siliceous Rocks ◽  
Group A ◽  
The Mediterranean ◽  
Mineral Soils

AbstractA thorough chemical, molecular and morphological study has been carried out on a problematic group in the genus Lepraria characterized by lobed, granular thalli with a raised rim and a preference for mosses, rocks and mineral soils in exposed, xeric habitats. The material examined was collected in seven countries of the Mediterranean-Macaronesian region, from chalk, carbonate rocks and derived soils (A-thalli), and from siliceous rocks and derived soils (B-thalli). The results of a phylogenetic analysis based on 93 ITS sequences (29 of which newly obtained) support the identification and the segregation of two taxa at species level, provisionally identified as Lepraria isidiata s. lat., (most of the A-thalli), and L. santosii s. lat. (B-thalli plus the remaining A-thalli), as the observed genetic variability is quite high. Three chemotypes were detected in L. isidiata s. lat., and seven in L. santosii s. lat. The two taxa are morphologically well characterized: in L. isidiata s. lat. the thallus is thicker and the propagules larger than in L. santosii s. lat. The first stages of thallus development from single propagules are described in both species. Some critical remarks are made about the increasing use of the species rank for taxa of Lepraria, which are morphologically and genetically scarcely characterized.

Genetic variability in envelope-associated protein genes of closely related group A strains of respiratory syncytial virus

1999 ◽  
Vol 59 (1) ◽  
pp. 89-99 ◽  
Author(s):  
HaoQiang Zheng ◽  
Greg A. Storch ◽  
Chunyi Zang ◽  
Teresa C.T. Peret ◽  
Chung S. Park ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Genetic Variability ◽  
Group A ◽  
Related Group ◽  
Syncytial Virus

scholarly journals SPATIAL-TEMPORAL DISTRIBUTION AND SEQUENCE DIVERSITY OF GROUP A HUMAN RESPIRATORY SYNCYTIAL VIRUSES IN KENYA PRECEDING THE EMERGENCE OF ON1 GENOTYPE

2021 ◽  
Author(s):  
JULIA WANGUI ◽  
David Nokes ◽  
Victor Mobegi ◽  
James Otieno ◽  
Charles Agoti ◽  
...  
Keyword(s):  
Temporal Distribution ◽  
Severe Pneumonia ◽  
Respiratory Illness ◽  
Haplotype Network ◽  
Rt Pcr ◽  
Group A ◽  
One Step ◽  
Respiratory Syncytial Viruses ◽  
Polymerase Chain ◽  
Syncytial Virus

Background: Human respiratory syncytial virus (HRSV) is a major cause of severe viral acute respiratory illness and contributes significantly to severe pneumonia cases in Africa. Little is known about its spatial-temporal distribution as defined by its genetic diversity. Methods: A retrospective study conducted utilizing archived nasopharyngeal specimens from patients attending outpatient clinics in hospitals located in five demographically and climatically distinct regions of Kenya; Coast, Western, Highlands, Eastern and Nairobi. The viral total RNA was extracted and tested using multiplex real time RT-PCR (reverse transcriptase polymerase chain reaction). A segment of the G-gene was amplified using one-step RT-PCR and sequenced by Sanger di-deoxy method. Bayesian analysis of phylogeny was utilized and subsequently median joining methods for haplotype network reconstruction. Results: Three genotypes of HRSVA were detected; GA5 (14.0%), GA2 (33.1%) and NA1 (52.9%). HRSVA prevalence varied by location from 33% to 13.2% in the Highlands and the Eastern regions respectively. The mean nucleotide diversity (Pi(π)) varied by genotype: highest of 0.018 for GA5 and lowest of 0.005 for NA1. A total of 58 haplotypes were identified (GA5 10; GA2 20; NA1 28). These haplotypes were introduced into the population locally by single haplotypes and additional subsidiary seeds amongst the GA2 and the NA1 haplotypes. Conclusions: HRSVA was found across all the regions throughout the study period and comprised three genotypes; GA5, GA2 and NA1 genotypes. The genotypes were disproportionately distributed across the regions with GA5 gradually increasing towards the Western zones and decreasing towards the Eastern zones of the country.

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