Patterns of circulating hepatitis B virus serum nucleic acids during lamivudine therapy

2003 ◽  
Vol 71 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Wei Zhang ◽  
Hans Jörg Hacker ◽  
Mehmet Tokus ◽  
Thomas Bock ◽  
Claus H. Schröder
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nucleic Acids ◽  
Lamivudine Therapy ◽  
B Virus

Patterns of Circulating Hepatitis B Virus Serum Nucleic Acids during Lamivudine Therapy

2004 ◽  
Vol 1022 (1) ◽  
pp. 271-281 ◽  
Author(s):  
HANS JÖRG HACKER ◽  
WEI ZHANG ◽  
MEHMET TOKUS ◽  
THOMAS BOCK ◽  
CLAUS H. SCHRÖDER
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nucleic Acids ◽  
Lamivudine Therapy ◽  
B Virus

scholarly journals Emergence of a Novel Mutation in the FLLA Region of Hepatitis B Virus during Lamivudine Therapy

2005 ◽  
Vol 49 (7) ◽  
pp. 2618-2624 ◽  
Author(s):  
S. Balakrishna Pai ◽  
A. Mithat Bozdayi ◽  
Rekha B. Pai ◽  
Tolunay Beker ◽  
Mustafa Sarioglu ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Novel Mutation ◽  
Site Directed Mutagenesis ◽  
Human Hepatoma Cells ◽  
Lamivudine Therapy ◽  
Major Mechanism ◽  
B Virus ◽  
Novel Variant ◽  
Ymdd Motif

ABSTRACT The emergence of resistance to lamivudine has been one of the major stumbling blocks to successful treatment and control of hepatitis B virus (HBV) infections. The major mechanism of resistance has been attributed to the alteration in the YMDD motif of the HBV polymerase due to an amino acid change of rtM204 to V/I and an accompanying rtL180M conversion. A novel mutation pattern in a patient having clinical breakthrough under lamivudine therapy was discovered. The mutant had a rtL180C/M204I genotype and was detected after 2 years of therapy with lamivudine. To characterize this novel variant, site-directed mutagenesis was performed using a vector construct containing the HBV genome. Transient transfection studies in human hepatoma cells with HBV carrying the new mutant demonstrated that the rtL180C/M204I mutant was resistant to lamivudine up to 10 μM. The resistance profile was comparable to that of the previously reported rtL180 M/M204I-containing virus. These observations were further confirmed by generation of stable cultures transfected with the mutant virus.

scholarly journals Hepatitis B virus RNA is measurable in serum and can be a new marker for monitoring lamivudine therapy

2006 ◽  
Vol 41 (8) ◽  
pp. 785-790 ◽  
Author(s):  
Akinori Rokuhara ◽  
Akihiro Matsumoto ◽  
Eiji Tanaka ◽  
Takeji Umemura ◽  
Kaname Yoshizawa ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Lamivudine Therapy ◽  
Virus Rna ◽  
B Virus

Vertical transmission of hepatitis B virus despite maternal lamivudine therapy

The Lancet ◽  
2002 ◽  
Vol 359 (9316) ◽  
pp. 1488-1489 ◽  
Author(s):  
Syed N Kazim ◽  
Salma M Wakil ◽  
Luqman A Khan ◽  
Seyed E Hasnain ◽  
Shiv K Sarin
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Vertical Transmission ◽  
Lamivudine Therapy ◽  
B Virus

Efficacy of lamivudine therapy for advanced liver disease in patients with precore mutant hepatitis B virus infection awaiting liver transplantation1

2002 ◽  
Vol 74 (8) ◽  
pp. 1119-1124 ◽  
Author(s):  
Pietro Andreone ◽  
Maurizio Biselli ◽  
Annagiulia Gramenzi ◽  
Carmela Cursaro ◽  
Maria C. Morelli ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hepatitis B Virus Infection ◽  
Lamivudine Therapy ◽  
Advanced Liver Disease ◽  
B Virus ◽  
Precore Mutant

scholarly journals Sensitive Assay for Quantification of Hepatitis B Virus Mutants by Use of a Minor Groove Binder Probe and Peptide Nucleic Acids

2010 ◽  
Vol 48 (12) ◽  
pp. 4487-4494 ◽  
Author(s):  
Shuhei Hige ◽  
Yoichi Yamamoto ◽  
Shigeru Yoshida ◽  
Tomoe Kobayashi ◽  
Hiromasa Horimoto ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Minor Groove ◽  
Sensitive Assay ◽  
Minor Groove Binder ◽  
B Virus ◽  
Minor Groove Binder Probe ◽  
A Minor

Reversion from precore/core promoter mutants to wild-type hepatitis B virus during the course of lamivudine therapy

2002 ◽  
Vol 36 ◽  
pp. 86
Author(s):  
Hikmet Akkiz ◽  
Yilmaz Ergun ◽  
Salih Colakoglu ◽  
Macit Sandikci ◽  
Mehmet Serin ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Wild Type ◽  
Lamivudine Therapy ◽  
B Virus
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