Quantitative Epstein-Barr virus (EBV) serology in lung transplant recipients with primary EBV infection and/or post-transplant lymphoproliferative disease

2002 ◽  
Vol 69 (2) ◽  
pp. 258-266 ◽  
Author(s):  
Erik Verschuuren ◽  
Wim van der Bij ◽  
Wim de Boer ◽  
Wim Timens ◽  
Jaap Middeldorp ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Epstein Barr Virus ◽  
Lymphoproliferative Disease ◽  
Transplant Recipients ◽  
Post Transplant ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr ◽  
Lung Transplant Recipients

scholarly journals Post-transplant lymphoproliferative disorders and Epstein-Barr virus DNAemia in a cohort of lung transplant recipients

2011 ◽  
Vol 8 (1) ◽  
Author(s):  
Fausto Baldanti ◽  
Vanina Rognoni ◽  
Alessandro Cascina ◽  
Tiberio Oggionni ◽  
Carmine Tinelli ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Epstein Barr Virus ◽  
Lymphoproliferative Disorders ◽  
Transplant Recipients ◽  
Post Transplant ◽  
Barr Virus ◽  
Epstein Barr ◽  
Lung Transplant Recipients

scholarly journals Post-transplant lymphoproliferative disorder in childhood

2014 ◽  
Vol 155 (8) ◽  
pp. 313-318
Author(s):  
Anita Stréhn ◽  
László Szőnyi ◽  
Gergely Kriván ◽  
Lajos Kovács ◽  
György Reusz ◽  
...  
Keyword(s):  
Stem Cell ◽  
Lung Transplant ◽  
Epstein Barr Virus ◽  
Stem Cell Transplant ◽  
Lymphoproliferative Disease ◽  
Solid Organ ◽  
Cell Transplant ◽  
Post Transplant ◽  
Barr Virus ◽  
Epstein Barr

Introduction: Among possible complications of transplantation the post-transplant lymphoproliferative disease due to immunosuppressive therapy is of paramount importance. In most cases the direct modulating effect of Epstein–Barr virus on immune cells can be documented. Aim: The aim of the authors was to evaluate the incidence os post-transplant lymphoproliferative diseases in pediatric transplant patients in Hungary. Method: The study group included kidney, liver and lung transplant children followed up at the 1st Department of Pediatrics, Semmelweis University, Budapest and stem cell transplant children at Szent László Hospital, Budapest. Data were collected from 78 kidney, 109 liver and 17 lung transplant children as well as from 243 children who underwent allogenic stem cell transplantation. Results: Between 1998 and 2012, 13 children developed post-transplant lymphoproliferative disorder (8 solid organ transplanted and 5 stem cell transplanted children). The diagnosis was based on histological findings in all cases. Mortality was 3 out of the 8 solid organ transplant children and 4 out of the 5 stem cell transplant children. The highest incidence was observed among lung transplant children (17.6%). Conclusions: These data indicate that post-transplant lymphoproliferative disease is a rare but devastating complication of transplantation in children. The most important therapeutic approaches are reduction of immunosuppressive therapy, chemotherapy and rituximab. Early diagnosis may improve clinical outcome and, therefore, routine polymerase chain reaction screening for Epstein–Barr virus of high risk patients is recommended. Orv. Hetil., 2014, 155(8), 313–318.

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