Exact mass measurement on an electrospray ionization time-of-flight mass spectrometer: error distribution and selective averaging

2003 ◽  
Vol 38 (10) ◽  
pp. 1043-1053 ◽  
Author(s):  
Jiejun Wu ◽  
Heather McAllister
Keyword(s):  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
Mass Measurement ◽  
Time Of Flight ◽  
Error Distribution ◽  
Exact Mass Measurement ◽  
Exact Mass ◽  
Ionization Time ◽  
Flight Mass Spectrometer

scholarly journals Organic aerosol source apportionment in Zurich using an extractive electrospray ionization time-of-flight mass spectrometer (EESI-TOF-MS) – Part 2: Biomass burning influences in winter

2019 ◽  
Vol 19 (12) ◽  
pp. 8037-8062 ◽  
Author(s):  
Lu Qi ◽  
Mindong Chen ◽  
Giulia Stefenelli ◽  
Veronika Pospisilova ◽  
Yandong Tong ◽  
...  
Keyword(s):  
Electrospray Ionization ◽  
Source Apportionment ◽  
Mass Spectrometer ◽  
Biomass Burning ◽  
Time Of Flight ◽  
Organic Aerosol ◽  
Climate Impacts ◽  
Ionization Time ◽  
Flight Mass Spectrometer ◽  
Tof Ms

Abstract. Real-time, in situ molecular composition measurements of the organic fraction of fine particulate matter (PM2.5) remain challenging, hindering a full understanding of the climate impacts and health effects of PM2.5. In particular, the thermal decomposition and ionization-induced fragmentation affecting current techniques has limited a detailed investigation of secondary organic aerosol (SOA), which typically dominates OA. Here we deploy a novel extractive electrospray ionization time-of-flight mass spectrometer (EESI-TOF-MS) during winter 2017 in downtown Zurich, Switzerland, which overcomes these limitations, together with an Aerodyne high-resolution time-of-flight aerosol mass spectrometer (HR-TOF-AMS) and supporting instrumentation. Positive matrix factorization (PMF) implemented within the Multilinear Engine (ME-2) program was applied to the EESI-TOF-MS data to quantify the primary and secondary contributions to OA. An 11-factor solution was selected as the best representation of the data, including five primary and six secondary factors. Primary factors showed influence from cooking, cigarette smoke, biomass burning (two factors) and a special local unknown event occurred only during two nights. Secondary factors were affected by biomass burning (three factors, distinguished by temperature and/or wind direction), organonitrates, monoterpene oxidation, and undetermined regional processing, in particular the contributions of wood combustion. While the AMS attributed slightly over half the OA mass to SOA but did not identify its source, the EESI-TOF-MS showed that most (>70 %) of the SOA was derived from biomass burning. Together with significant contributions from less aged biomass burning factors identified by both AMS and EESI-TOF-MS, this firmly establishes biomass burning as the single most important contributor to OA mass at this site during winter. High correlation was obtained between EESI-TOF-MS and AMS PMF factors where specific analogues existed, as well as between total signal and POA–SOA apportionment. This suggests the EESI-TOF-MS apportionment in the current study can be approximately taken at face value, despite ion-by-ion differences in relative sensitivity. The apportionment of specific ions measured by the EESI-TOF-MS (e.g., levoglucosan, nitrocatechol, and selected organic acids) and utilization of a cluster analysis-based approach to identify key marker ions for the EESI-TOF-MS factors are investigated. The interpretability of the EESI-TOF-MS results and improved source separation relative to the AMS within this pilot campaign validate the EESI-TOF-MS as a promising approach to source apportionment and atmospheric composition research.

scholarly journals Organic aerosol source apportionment in Zurich using an extractive electrospray ionization time-of-flight mass spectrometer (EESI-TOF-MS) – Part 1: Biogenic influences and day–night chemistry in summer

2019 ◽  
Vol 19 (23) ◽  
pp. 14825-14848 ◽  
Author(s):  
Giulia Stefenelli ◽  
Veronika Pospisilova ◽  
Felipe D. Lopez-Hilfiker ◽  
Kaspar R. Daellenbach ◽  
Christoph Hüglin ◽  
...  
Keyword(s):  
Electrospray Ionization ◽  
Source Apportionment ◽  
Mass Spectrometer ◽  
Time Of Flight ◽  
Organic Aerosol ◽  
Night Time ◽  
Ionization Time ◽  
Flight Mass Spectrometer ◽  
Two Factors ◽  
Tof Ms

Abstract. Improving the understanding of the health and climate impacts of aerosols remains challenging and is restricted by the limitations of current measurement techniques. Detailed investigation of secondary organic aerosol (SOA), which is typically the dominating fraction of the organic aerosol (OA), requires instrumentation capable of real-time, in situ measurements of molecular composition. In this study, we present the first ambient measurements by a novel extractive electrospray ionization time-of-flight mass spectrometer (EESI-TOF-MS). The EESI-TOF-MS was deployed along with a high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS) during summer 2016 at an urban location (Zurich, Switzerland). Positive matrix factorization (PMF), implemented within the Multilinear Engine (ME-2), was applied to the data from both instruments to quantify the primary and secondary contributions to OA. From the EESI-TOF-MS analysis, a six-factor solution was selected as the most representative and interpretable solution for the investigated dataset, including two primary and four secondary factors. The primary factors are dominated by cooking and cigarette smoke signatures while the secondary factors are discriminated according to their daytime (two factors) and night-time (two factors) chemistry. All four factors showed strong influence by biogenic emissions but exhibited significant day–night differences. Factors dominating during daytime showed predominantly ions characteristic of monoterpene and sesquiterpene oxidation while the night-time factors included less oxygenated terpene oxidation products, as well as organonitrates which were likely derived from NO3 radical oxidation of monoterpenes. Overall, the signal measured by the EESI-TOF-MS and AMS showed a good correlation. Further, the two instruments were in excellent agreement in terms of both the mass contribution apportioned to the sum of POA and SOA factors and the total SOA signal. However, while the oxygenated organic aerosol (OOA) factors separated by AMS analysis exhibited a flat diurnal pattern, the EESI-TOF-MS factors illustrated significant chemical variation throughout the day. The captured variability, inaccessible from AMS PMF analysis, was shown to be consistent with the variations in the physiochemical processes influencing chemical composition and SOA formation. The improved source separation and interpretability of EESI-TOF-MS results suggest it to be a promising approach to source apportionment and atmospheric composition research.

Studies of Noncovalent Complexes in an Electrospray Ionization/ Time-of-Flight Mass Spectrometer

2003 ◽  
pp. 239-249 ◽  
Author(s):  
Andrew N. Krutchinsky ◽  
Ayeda Ayed ◽  
Lynda J. Donald ◽  
Werner Ens ◽  
Harry W. Duckworth ◽  
...  
Keyword(s):  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
Time Of Flight ◽  
Noncovalent Complexes ◽  
Ionization Time ◽  
Flight Mass Spectrometer

Design and performance of an electrospray ionization time-of-flight mass spectrometer

2000 ◽  
Vol 71 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Kristina Håkansson ◽  
Roman A. Zubarev ◽  
Per Håkansson ◽  
Viktor Laiko ◽  
Alexander F. Dodonov
Keyword(s):  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
Time Of Flight ◽  
Ionization Time ◽  
Flight Mass Spectrometer ◽  
And Performance

scholarly journals An extractive electrospray ionization time-of-flight mass spectrometer (EESI-TOF) for online measurement of atmospheric aerosol particles

2019 ◽  
Vol 12 (9) ◽  
pp. 4867-4886 ◽  
Author(s):  
Felipe D. Lopez-Hilfiker ◽  
Veronika Pospisilova ◽  
Wei Huang ◽  
Markus Kalberer ◽  
Claudia Mohr ◽  
...  
Keyword(s):  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
Aerosol Particles ◽  
Time Of Flight ◽  
Organic Aerosol ◽  
Molecular Formula ◽  
Actual Distribution ◽  
Ionization Time ◽  
Flight Mass Spectrometer ◽  
Atmospherically Relevant

Abstract. Real-time, online measurements of atmospheric organic aerosol (OA) composition are an essential tool for determining the emissions sources and physicochemical processes governing aerosol effects on climate and health. However, the reliance of current techniques on thermal desorption, hard ionization, and/or separated collection/analysis stages introduces significant uncertainties into OA composition measurements, hindering progress towards these goals. To address this gap, we present a novel, field-deployable extractive electrospray ionization time-of-flight mass spectrometer (EESI-TOF), which provides online, near-molecular (i.e., molecular formula) OA measurements at atmospherically relevant concentrations without analyte fragmentation or decomposition. Aerosol particles are continuously sampled into the EESI-TOF, where they intersect a spray of charged droplets generated by a conventional electrospray probe. Soluble components are extracted and then ionized as the droplets are evaporated. The EESI-TOF achieves a linear response to mass, with detection limits on the order of 1 to 10 ng m−3 in 5 s for typical atmospherically relevant compounds. In contrast to conventional electrospray systems, the EESI-TOF response is not significantly affected by a changing OA matrix for the systems investigated. A slight decrease in sensitivity in response to increasing absolute humidity is observed for some ions. Although the relative sensitivities to a variety of commercially available organic standards vary by more than a factor of 30, the bulk sensitivity to secondary organic aerosol generated from individual precursor gases varies by only a factor of 15. Further, the ratio of compound-by-compound sensitivities between the EESI-TOF and an iodide adduct FIGAERO-I-CIMS varies by only ±50 %, suggesting that EESI-TOF mass spectra indeed reflect the actual distribution of detectable compounds in the particle phase. Successful deployments of the EESI-TOF for laboratory environmental chamber measurements, ground-based ambient sampling, and proof-of-concept measurements aboard a research aircraft highlight the versatility and potential of the EESI-TOF system.

scholarly journals An Extractive Electrospray Ionization Time-of-Flight Mass Spectrometer (EESI-TOF) for online measurement of atmospheric aerosol particles

2019 ◽  
Author(s):  
Felipe D. Lopez-Hilfiker ◽  
Veronika Pospisilova ◽  
Wei Huang ◽  
Markus Kalberer ◽  
Claudia Mohr ◽  
...  
Keyword(s):  
Electrospray Ionization ◽  
Mass Spectrometer ◽  
Aerosol Particles ◽  
Time Of Flight ◽  
Absolute Humidity ◽  
Actual Distribution ◽  
Ionization Time ◽  
Flight Mass Spectrometer ◽  
Online Measurements ◽  
Atmospherically Relevant

Abstract. Real-time, online measurements of atmospheric organic aerosol (OA) composition are an essential tool for determining the emissions sources and physicochemical processes governing aerosol effects on climate and health. However, the reliance of current techniques on thermal desorption, hard ionization, and/or separated collection/analysis stages introduces significant uncertainties into OA composition measurements, hindering progress towards these goals. To address this gap, we present a novel, field-deployable extractive electrospray ionization time-of-flight mass spectrometer (EESI-TOF), which provides online, near-molecular OA measurements at atmospherically relevant concentrations without analyte fragmentation or decomposition. Aerosol particles are continuously sampled into the EESI-TOF, where they intersect a spray of charged droplets generated by a conventional electrospray probe. Soluble components are extracted, and then ionized as the droplets are evaporated. The EESI-TOF achieves a linear response to mass, with detection limits on the order of 1 to 10 ng m−3 for typical atmospherically-relevant compounds. In contrast to conventional electrospray systems, the EESI-TOF response is not significantly affected by a changing OA matrix, while a slight decrease in sensitivity in response to increasing absolute humidity is observed for some ions. Although the relative sensitivities to a variety of commercially available organic standards vary by approximately a factor of 30, the bulk sensitivity to most SOA compounds varies by only a factor of 6. Further, the ratio of compound-by-compound sensitivities between the EESI-TOF and an iodide adduct FIGAERO-CIMS vary by only ± 50 %, suggesting that EESI-TOF mass spectra indeed reflect the actual distribution of detectable compounds in the particle phase. Successful deployments of the EESI-TOF for laboratory environmental chamber measurements, ground-based ambient sampling, and proof-of-concept measurements aboard a research aircraft highlight the versatility and potential of the EESI-TOF system.

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