Targeted fatty acid metabolomic to discover Parkinson’s disease associated metabolic alteration

2021 ◽  
Author(s):  
Junjie Zhang ◽  
Lulu Liu ◽  
Lijiang Zhang ◽  
Simei Chen ◽  
Yusen Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fatty Acid ◽  
Metabolic Alteration

scholarly journals Defects in Very Long Chain Fatty Acid Synthesis Enhance Alpha-Synuclein Toxicity in a Yeast Model of Parkinson's Disease

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e15946 ◽  
Author(s):  
Yong Joo Lee ◽  
Shaoxiao Wang ◽  
Sunny R. Slone ◽  
Talene A. Yacoubian ◽  
Stephan N. Witt
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Alpha Synuclein ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Long Chain ◽  
Yeast Model

scholarly journals Parkinson’s disease patients’ short chain fatty acids production capacity after in vitro fecal fiber fermentation

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Florence Baert ◽  
Christophe Matthys ◽  
Jarissa Maselyne ◽  
Christof Van Poucke ◽  
Els Van Coillie ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fatty Acid ◽  
Acid Production ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Fatty Acid Production ◽  
Butyrate Production

AbstractAnimal models indicate that butyrate might reduce motor symptoms in Parkinson’s disease. Some dietary fibers are butyrogenic, but in Parkinson’s disease patients their butyrate stimulating capacity is unknown. Therefore, we investigated different fiber supplements’ effects on short-chain fatty acid production, along with potential underlying mechanisms, in Parkinson’s patients and age-matched healthy controls. Finally, it was investigated if this butyrate production could be confirmed by using fiber-rich vegetables. Different fibers (n = 40) were evaluated by in vitro fermentation experiments with fecal samples of Parkinson’s patients (n = 24) and age-matched healthy volunteers (n = 39). Short-chain fatty acid production was analyzed by headspace solid-phase micro-extraction gas chromatography-mass spectrometry. Clostridium coccoides and C. leptum were quantified through 16S-rRNA gene-targeted group-specific qPCR. Factors influencing short-chain fatty acid production were investigated using linear mixed models. After fiber fermentation, butyrate concentration varied between 25.6 ± 16.5 µmol/g and 203.8 ± 91.9 µmol/g for Parkinson’s patients and between 52.7 ± 13.0 µmol/g and 229.5 ± 42.8 µmol/g for controls. Inulin had the largest effect, while xanthan gum had the lowest production. Similar to fiber supplements, inulin-rich vegetables, but also fungal β-glucans, stimulated butyrate production most of all vegetable fibers. Parkinson’s disease diagnosis limited short-chain fatty acid production and was negatively associated with butyrate producers. Butyrate kinetics during 48 h fermentation demonstrated a time lag effect in Parkinson’s patients, especially in fructo-oligosaccharide fermentation. Butyrate production can be stimulated in Parkinson’s patients, however, remains reduced compared to healthy controls. This is a first step in investigating dietary fiber’s potential to increase short-chain fatty acids in Parkinson’s disease.

scholarly journals Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?

2021 ◽  
Vol 8 ◽  
Author(s):  
Collin M. Bantle ◽  
Warren D. Hirst ◽  
Andreas Weihofen ◽  
Evgeny Shlevkov
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fatty Acid ◽  
Mitochondrial Dysfunction ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Glutamate Metabolism ◽  
Cell Type ◽  
Therapeutic Development ◽  
The Brain

Mitochondrial dysfunction is a hallmark of Parkinson’s disease (PD). Astrocytes are the most abundant glial cell type in the brain and are thought to play a pivotal role in the progression of PD. Emerging evidence suggests that many astrocytic functions, including glutamate metabolism, Ca2+ signaling, fatty acid metabolism, antioxidant production, and inflammation are dependent on healthy mitochondria. Here, we review how mitochondrial dysfunction impacts astrocytes, highliting translational gaps and opening new questions for therapeutic development.

Fatty acid incorporation depicts brain activity in a rat model of Parkinson's disease

1998 ◽  
Vol 807 (1-2) ◽  
pp. 177-181 ◽  
Author(s):  
Takanori Hayakawa ◽  
Michael C.J. Chang ◽  
Jane M. Bell ◽  
Ruth Seeman ◽  
Stanley I. Rapoport ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fatty Acid ◽  
Rat Model ◽  
Brain Activity ◽  
Acid Incorporation ◽  
Fatty Acid Incorporation
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