Analysis of low molecular weight compounds using MALDI- and LDI-TOF-MS: Direct detection of active pharmaceutical ingredients in different formulations

2017 ◽  
Vol 52 (11) ◽  
pp. 752-758 ◽  
Author(s):  
João L. Bronzel ◽  
Cintia D.F. Milagre ◽  
Humberto M.S. Milagre
Keyword(s):  
Molecular Weight ◽  
Direct Detection ◽  
Low Molecular Weight ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Low Molecular Weight Compounds ◽  
Tof Ms

New Type of Matrix for Analysis of Low Molecular Weight Compounds by MALDI-TOF MS

Heterocycles ◽  
2012 ◽  
Vol 85 (4) ◽  
pp. 927 ◽  
Author(s):  
Masamichi Nakakoshi ◽  
Masayoshi Tsubuki ◽  
Natsumi Funakoshi ◽  
Hiroki Nakajima
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Low Molecular Weight Compounds ◽  
New Type ◽  
Tof Ms

scholarly journals Direct Detection of Low-Molecular-Weight Compounds in 2D and 3D Aptasensors by Biolayer Interferometry

ACS Sensors ◽  
2020 ◽  
Vol 5 (8) ◽  
pp. 2326-2330
Author(s):  
Anthony Vignon ◽  
Arthur Flaget ◽  
Maxime Michelas ◽  
Mehdi Djeghdir ◽  
Eric Defrancq ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Direct Detection ◽  
Low Molecular Weight ◽  
Biolayer Interferometry ◽  
Low Molecular Weight Compounds ◽  
2D And 3D

Low Molecular Weight Microfibers with Light Sensing Properties

2017 ◽  
Vol 54 (4) ◽  
pp. 655-658
Author(s):  
Andrei Bejan ◽  
Dragos Peptanariu ◽  
Bogdan Chiricuta ◽  
Elena Bicu ◽  
Dalila Belei
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
X Ray Diffraction ◽  
Aromatic Rings ◽  
X Ray ◽  
Force Microscopy ◽  
Light Sensing ◽  
Sensing Applications ◽  
Atomic Force ◽  
Low Molecular Weight Compounds

Microfibers were obtained from organic low molecular weight compounds based on heteroaromatic and aromatic rings connected by aliphatic spacers. The obtaining of microfibers was proved by scanning electron microscopy. The deciphering of the mechanism of microfiber formation has been elucidated by X-ray diffraction, infrared spectroscopy, and atomic force microscopy measurements. By exciting with light of different wavelength, florescence microscopy revealed a specific optical response, recommending these materials for light sensing applications.

Inhibitors of Cholinesterases in Pharmacology: the Current Trends

2020 ◽  
Vol 20 (15) ◽  
pp. 1532-1542 ◽  
Author(s):  
Miroslav Pohanka
Keyword(s):  
Molecular Weight ◽  
Cholinesterase Inhibitors ◽  
Recent Literature ◽  
Nerve Agents ◽  
Low Molecular Weight ◽  
Toxic Compounds ◽  
Current Trends ◽  
Low Molecular Weight Compounds ◽  
Wide Group ◽  
Anti Inflammation

Inhibitors of cholinesterases are a wide group of low molecular weight compounds with a significant role in the current pharmacology. Besides the pharmacological importance, they are also known as toxic compounds like military nerve agents. In the pharmacology, drugs for Alzheimer disease, myasthenia gravis and prophylaxis of poisoning by nerve agents can be mentioned as the relevant applications. Besides this, anti-inflammation and antiphrastic drugs are other pharmacological applications of these inhibitors. This review is focused on a survey of cholinesterase inhibitors with known or expected pharmacological impact and indications of their use. Recent literature with comments is provided here as well.

scholarly journals Holistic Metabolomic Laboratory-Developed Test (LDT): Development and Use for the Diagnosis of Early-Stage Parkinson’s Disease

Metabolites ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 14
Author(s):  
Petr G. Lokhov ◽  
Dmitry L. Maslov ◽  
Steven Lichtenberg ◽  
Oxana P. Trifonova ◽  
Elena E. Balashova
Keyword(s):  
Parkinson’S Disease ◽  
Molecular Weight ◽  
Parkinson's Disease ◽  
High Resolution Mass Spectrometry ◽  
Early Stage ◽  
Disease Diagnosis ◽  
The Body ◽  
Low Molecular Weight ◽  
Low Molecular Weight Compounds

A laboratory-developed test (LDT) is a type of in vitro diagnostic test that is developed and used within a single laboratory. The holistic metabolomic LDT integrating the currently available data on human metabolic pathways, changes in the concentrations of low-molecular-weight compounds in the human blood during diseases and other conditions, and their prevalent location in the body was developed. That is, the LDT uses all of the accumulated metabolic data relevant for disease diagnosis and high-resolution mass spectrometry with data processing by in-house software. In this study, the LDT was applied to diagnose early-stage Parkinson’s disease (PD), which currently lacks available laboratory tests. The use of the LDT for blood plasma samples confirmed its ability for such diagnostics with 73% accuracy. The diagnosis was based on relevant data, such as the detection of overrepresented metabolite sets associated with PD and other neurodegenerative diseases. Additionally, the ability of the LDT to detect normal composition of low-molecular-weight compounds in blood was demonstrated, thus providing a definition of healthy at the molecular level. This LDT approach as a screening tool can be used for the further widespread testing for other diseases, since ‘omics’ tests, to which the metabolomic LDT belongs, cover a variety of them.

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