Molecular formula analysis of fragment ions by isotope-selective collision-induced dissociation tandem mass spectrometry of pharmacologically active compounds

2014 ◽  
Vol 49 (12) ◽  
pp. 1322-1329 ◽  
Author(s):  
Giuliana Bianco ◽  
Alessandro Buchicchio ◽  
Filomena Lelario ◽  
Tommaso R.I. Cataldi
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Collision Induced Dissociation ◽  
Molecular Formula ◽  
Tandem Mass ◽  
Active Compounds ◽  
Fragment Ions ◽  
Pharmacologically Active ◽  
Pharmacologically Active Compounds

Fatty acid neutral losses observed in tandem mass spectrometry with collision-induced dissociation allows regiochemical assignment of sulfoquinovosyl-diacylglycerols

2013 ◽  
Vol 48 (2) ◽  
pp. 205-215 ◽  
Author(s):  
Rosalia Zianni ◽  
Giuliana Bianco ◽  
Filomena Lelario ◽  
Ilario Losito ◽  
Francesco Palmisano ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fatty Acid ◽  
Tandem Mass Spectrometry ◽  
Collision Induced Dissociation ◽  
Tandem Mass

Isolation and structural identification of 9hydroxy-9desmethyl-cyclosporine

1990 ◽  
Vol 36 (11) ◽  
pp. 1875-1879 ◽  
Author(s):  
L D Bowers ◽  
D D Norman ◽  
X X Yan ◽  
D Scheeler ◽  
K L Carlson
Keyword(s):  
Mass Spectrometry ◽  
Fast Atom Bombardment ◽  
Structural Identification ◽  
Collision Induced Dissociation ◽  
Tandem Mass ◽  
Hplc Fraction ◽  
Nomenclature System ◽  
Fragment Ions ◽  
Tandem Mass Spectroscopy ◽  
The Difference

Abstract A metabolite of cyclosporine has been isolated and its structure identified through use of HPLC and tandem mass spectroscopy. Fast atom bombardment mass spectrometry of an HPLC fraction co-eluting with 1 eta hydroxy-cyclosporine (M17) indicated that the mass of this metabolite was 2 Da greater than that of cyclosporine. Further isolation by HPLC yielded a pure fraction, which we analyzed with tandem mass spectrometry. Linear acyl fragment ions originating from the metabolite under collision-induced dissociation were consistent with the difference in mass being associated with amino acid 9 in the cyclosporine backbone. We propose a nomenclature system for future discussion of cyclosporine metabolites.

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