New method to determine the total carbonyl functional group content in extractable particulate organic matter by tandem mass spectrometry

2008 ◽  
Vol 43 (8) ◽  
pp. 1089-1098 ◽  
Author(s):  
J. Dron ◽  
W. Zheng ◽  
N. Marchand ◽  
H. Wortham
Keyword(s):  
Mass Spectrometry ◽  
Organic Matter ◽  
Tandem Mass Spectrometry ◽  
Particulate Organic Matter ◽  
Functional Group ◽  
New Method ◽  
Tandem Mass ◽  
Total Carbonyl ◽  
Group Content

scholarly journals Pharmacokinetics and Bioavailability Study of Monocrotaline in Mouse Blood by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Lianguo Chen ◽  
Bin Zhang ◽  
Jinlai Liu ◽  
Zhehua Fan ◽  
Ziwei Weng ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Quantitative Determination ◽  
Ultra Performance Liquid Chromatography ◽  
New Method ◽  
Tandem Mass ◽  
Mouse Blood ◽  
Detection Range

Background and Aims. The present study aimed to develop a simple and sensitive method for quantitative determination of monocrotaline (MCT) in mouse blood employing ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI/MS/MS) using rhynchophylline as an internal standard. Methods. Proteins present in the blood samples were precipitated using acetonitrile. MCT was separated using a 1.7-μm ethylene bridged hybrid (BEH) C18 column (2.1 mm × 50 mm) with a gradient elution program and a constant flow rate of 0.4 mL/min. The LC mobile phase consisted of 10 mmol/L ammonium acetate (containing 0.1% formic acid) and acetonitrile. The total elution time was 4.0 min. The analytes were detected on a UPLC-ESI mass spectrometer in multiple reaction monitoring (MRM) mode and quantified. Results. The new method for the determination of MCT has a satisfactory linear detection range of 1-2000 ng/mL and excellent linearity (r = 0.9971). The lower limit of quantification (LLOQ) of MCT is 1.0 ng/mL. Intra- and interassay precisions of MCT were ≤13% with an accuracy from 96.2% to 106.6%. The average recovery of the new method was >75.0%, and matrix effects were between 89.0% and 94.3%. Based on the pharmacokinetics data, the bioavailability of MCT in mice was 88.3% after oral administration. Conclusions. The results suggest that the newly standardized method for quantitative determination of MCT in whole blood is fast, reliable, specific, sensitive, and suitable for pharmacokinetic studies of MCT after intravenous or intragastric administration.

Strontium isotopic analysis of environmental microsamples by inductively coupled plasma - tandem mass spectrometry

2022 ◽  
Author(s):  
Stefano Bertinetti ◽  
Eduardo Bolea-Fernandez ◽  
Mery Malandrino ◽  
Beatrice Moroni ◽  
David Cappelletti ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Isotopic Analysis ◽  
New Method ◽  
Tandem Mass ◽  
Inductively Coupled ◽  
Icp Ms

In this work, a new method has been developed for accurate and precise Sr isotopic analysis of microsamples via inductively coupled plasma - tandem mass spectrometry (ICP-MS/MS). For introduction of...

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