scholarly journals Hyphenated mass spectrometric techniques—indispensable tools in clinical and forensic toxicology and in doping control

2006 ◽  
Vol 41 (11) ◽  
pp. 1399-1413 ◽  
Author(s):  
Hans H. Maurer
Keyword(s):  
Forensic Toxicology ◽  
Mass Spectrometric ◽  
Doping Control ◽  
In Doping ◽  
Clinical And Forensic Toxicology ◽  
Mass Spectrometric Techniques

Position of chromatographic techniques in screening for detection of drugs or poisons in clinical and forensic toxicology and/or doping control

2004 ◽  
Vol 42 (11) ◽  
Author(s):  
Hans H. Maurer
Keyword(s):  
Simultaneous Detection ◽  
Forensic Toxicology ◽  
Doping Control ◽  
Gas Chromatography Mass Spectrometry ◽  
Array Detector ◽  
Separation Power ◽  
Drug Classes ◽  
Pros And Cons ◽  
Full Scan ◽  
Clinical And Forensic Toxicology

AbstractThis paper reviews chromatographic screening procedures for simultaneous detection of several drug classes relevant to clinical and forensic toxicology or doping control in urine or blood using gas chromatography-mass spectrometry (GC-MS), liquid chromatography coupled with a diode-array detector (LC-DAD) or a mass spectrometer (LC-MS). The pros and cons of the different techniques and procedures are discussed leading to the following conclusions and perspectives. GC-MS, especially in the electron ionization full-scan mode, is still the method of choice for comprehensive screening providing best separation power, specificity and universality, although requiring derivatization. LC-DAD is also often used for screening, but its separation power and its specificity are still inferior to those of GC-MS. Finally, LC-MS has shown to be an ideal supplement, especially for the detection of more polar, thermolabile and/or low-dose drugs, especially in blood plasma. It may become the gold standard in clinical and forensic toxicology and doping control if, at a later date, the costs of the apparatus will be markedly reduced, the current disadvantages like irreproducibility of fragmentation, reduction of ionization by matrix, etc. will be overcome, and finally if one of the increasing number of quite different techniques will become the apparatus standard.

Isotope-dilution mass spectrometric quantification of the prodrug lisdexamfetamine in human urine in doping control analysis

2014 ◽  
Vol 28 (7) ◽  
pp. 781-786 ◽  
Author(s):  
Mario Thevis ◽  
Gerd Sigmund ◽  
Andreas Thomas ◽  
Matthias Vogel ◽  
Katja Walpurgis ◽  
...  
Keyword(s):  
Isotope Dilution ◽  
Human Urine ◽  
Mass Spectrometric ◽  
Doping Control ◽  
Control Analysis ◽  
In Doping

6α-Methylandrostenedione: gas chromatographic mass spectrometric detection in doping control

2008 ◽  
Vol 22 (3) ◽  
pp. 321-329 ◽  
Author(s):  
Maria K. Parr ◽  
Rymantas Kazlauskas ◽  
Nils Schlörer ◽  
Georg Opfermann ◽  
Thomas Piper ◽  
...  
Keyword(s):  
Mass Spectrometric ◽  
Doping Control ◽  
Mass Spectrometric Detection ◽  
In Doping ◽  
Chromatographic Mass
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