In Vivo Absolute Metabolite Quantification Using a Multiplexed ERETIC‐RX Array Coil for Whole‐Brain MR Spectroscopic Imaging

2021 ◽  
Author(s):  
Bijaya Thapa ◽  
Azma Mareyam ◽  
Jason Stockmann ◽  
Bernhard Strasser ◽  
Boris Keil ◽  
...  
Keyword(s):  
Spectroscopic Imaging ◽  
Whole Brain ◽  
Metabolite Quantification ◽  
Mr Spectroscopic Imaging ◽  
Array Coil

scholarly journals An integrated RF-receive/B0-shim array coil boosts performance of whole-brain MR spectroscopic imaging at 7 T

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Morteza Esmaeili ◽  
Jason Stockmann ◽  
Bernhard Strasser ◽  
Nicolas Arango ◽  
Bijaya Thapa ◽  
...  
Keyword(s):  
High Field ◽  
Human Subjects ◽  
Spectroscopic Imaging ◽  
Metabolic Imaging ◽  
Ultra High Field ◽  
Whole Brain ◽  
Metabolite Quantification ◽  
Noise Ratio ◽  
Array Coil

Abstract Metabolic imaging of the human brain by in-vivo magnetic resonance spectroscopic imaging (MRSI) can non-invasively probe neurochemistry in healthy and disease conditions. MRSI at ultra-high field (≥ 7 T) provides increased sensitivity for fast high-resolution metabolic imaging, but comes with technical challenges due to non-uniform B0 field. Here, we show that an integrated RF-receive/B0-shim (AC/DC) array coil can be used to mitigate 7 T B0 inhomogeneity, which improves spectral quality and metabolite quantification over a whole-brain slab. Our results from simulations, phantoms, healthy and brain tumor human subjects indicate improvements of global B0 homogeneity by 55%, narrower spectral linewidth by 29%, higher signal-to-noise ratio by 31%, more precise metabolite quantification by 22%, and an increase by 21% of the brain volume that can be reliably analyzed. AC/DC shimming provide the highest correlation (R2 = 0.98, P = 0.001) with ground-truth values for metabolite concentration. Clinical translation of AC/DC and MRSI is demonstrated in a patient with mutant-IDH1 glioma where it enables imaging of D-2-hydroxyglutarate oncometabolite with a 2.8-fold increase in contrast-to-noise ratio at higher resolution and more brain coverage compared to previous 7 T studies. Hence, AC/DC technology may help ultra-high field MRSI become more feasible to take advantage of higher signal/contrast-to-noise in clinical applications.

scholarly journals Physiological neuronal decline in healthy aging human brain — An in vivo study with MRI and short echo-time whole-brain 1H MR spectroscopic imaging

NeuroImage ◽  
2016 ◽  
Vol 137 ◽  
pp. 45-51 ◽  
Author(s):  
Xiao-Qi Ding ◽  
Andrew A. Maudsley ◽  
Mohammad Sabati ◽  
Sulaiman Sheriff ◽  
Birte Schmitz ◽  
...  
Keyword(s):  
Human Brain ◽  
Healthy Aging ◽  
Spectroscopic Imaging ◽  
In Vivo Study ◽  
Whole Brain ◽  
Echo Time ◽  
Short Echo Time ◽  
Mr Spectroscopic Imaging

Altered phosphoethanolamine levels in alcoholic liver disease assessed by in vivo proton-decoupled 31P MR spectroscopic imaging

2001 ◽  
Vol 120 (5) ◽  
pp. A116-A116
Author(s):  
H SCHLEMMER ◽  
T SAWATZKI ◽  
I DORNACHER ◽  
S SAMMET ◽  
M HELLENSCHMIDT ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Spectroscopic Imaging ◽  
Mr Spectroscopic Imaging

In Vivo 1H MR Spectroscopic Imaging of Human Brain

1994 ◽  
Vol 31 (2) ◽  
pp. 185
Author(s):  
Yong Whee Bahk ◽  
Kyung Sub Shinn ◽  
Tae Suk Suh ◽  
Bo Young Choe ◽  
Kyo Ho Choi
Keyword(s):  
Human Brain ◽  
Spectroscopic Imaging ◽  
Mr Spectroscopic Imaging

scholarly journals In vivo hyperpolarized 13C MR spectroscopic imaging with 1H decoupling

2009 ◽  
Vol 197 (1) ◽  
pp. 100-106 ◽  
Author(s):  
Albert P. Chen ◽  
James Tropp ◽  
Ralph E. Hurd ◽  
Mark Van Criekinge ◽  
Lucas G. Carvajal ◽  
...  
Keyword(s):  
Spectroscopic Imaging ◽  
Hyperpolarized 13C ◽  
Mr Spectroscopic Imaging

scholarly journals Regional Metabolite Concentrations in Aging Human Brain: Comparison of Short-TE Whole Brain MR Spectroscopic Imaging and Single Voxel Spectroscopy at 3T

2019 ◽  
Vol 30 (2) ◽  
pp. 251-261 ◽  
Author(s):  
Helen Maghsudi ◽  
Birte Schmitz ◽  
Andrew A. Maudsley ◽  
Sulaiman Sheriff ◽  
Paul Bronzlik ◽  
...  
Keyword(s):  
Human Brain ◽  
Spectroscopic Imaging ◽  
Whole Brain ◽  
Single Voxel ◽  
Metabolite Concentrations ◽  
Mr Spectroscopic Imaging

Altered phosphoethanolamine levels in alcoholic liver disease assessed by in vivo proton-decoupled 31P MR spectroscopic imaging

2001 ◽  
Vol 120 (5) ◽  
pp. A116
Author(s):  
Heinz-Peter Schlemmer ◽  
Tanja Sawatzki ◽  
Ines Dornacher ◽  
Steffen Sammet ◽  
Michael Hellenschmidt ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Spectroscopic Imaging ◽  
Mr Spectroscopic Imaging
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