Gray Matter‐Restricted Whole Spinal Cord Involvement in a Young Woman with SARS‐CoV ‐2 Infection

2021 ◽  
Author(s):  
Dumitru Ciolac ◽  
Igor Crivorucica ◽  
Eremei Zota ◽  
Diana Manea ◽  
Daniela Efremova ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Young Woman ◽  
Gray Matter ◽  
Spinal Cord Involvement

scholarly journals Hemodynamic infarction of the spinal cord: involvement of the gray matter plus the border-zone between the central and peripheral arteries

Spinal Cord ◽  
2004 ◽  
Vol 43 (5) ◽  
pp. 306-310 ◽  
Author(s):  
K Ishizawa ◽  
T Komori ◽  
T Shimada ◽  
E Arai ◽  
K Imanaka ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Gray Matter ◽  
Border Zone ◽  
Peripheral Arteries ◽  
Spinal Cord Involvement

scholarly journals Spinal cord involvement in Kearns-Sayre syndrome: a neuroimaging study

2020 ◽  
Vol 62 (10) ◽  
pp. 1315-1321 ◽  
Author(s):  
Pasquini Luca ◽  
Guarnera Alessia ◽  
Rossi-Espagnet Maria Camilla ◽  
Napolitano Antonio ◽  
Martinelli Diego ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Gray Matter ◽  
Brain Mri ◽  
Spinal Disease ◽  
Spinal Cord Lesions ◽  
Chi Square ◽  
Disability Score ◽  
Spinal Cord Involvement ◽  
Chi Square Test ◽  
Brain Involvement

Abstract Purpose Spinal cord involvement in Kearns-Sayre (KSS) syndrome could be more frequent than commonly thought. Our aims were to evaluate the involvement of the spinal cord in patients with KSS by means of MRI and to investigate possible correlations of spinal and brain disease with patient disability. Methods Eleven patients with KSS disease and spinal cord MRI were retrospectively recruited. The severity of spinal disease was defined as follows: grade 0 (none), grade 1 (focal), and grade 2 (extensive). We calculated a radiologic score of brain involvement based on typical features. We performed a chi-square test to correlate spinal cord and brain MRI involvement to patient disability. For significant variables, a contingency coefficient, phi factor, and Cramer’s V were also computed. Results Spinal cord lesions were detected in 6/11 patients, showing four patterns: involvement of gray matter, gray matter and posterior columns, posterior columns, and anterior columns. The severity of spinal disease was grade 1 in two and grade 2 in four patients. All patients showed brain involvement (9-point average for patients with spinal involvement and 10 for the others). A significant correlation was found between disability score and spinal cord involvement (χ2 = 7.64; p = 0.022) or brain score (χ2 = 26.85; p = 0.043). Significance for brain score-disability correlation increased with the spinal cord as a cofactor (χ2 = 24.51; p = 0.017, phi factor = 1.201, Cramer’s V = 0.849, contingency effect = 0.767; p = 0.017). Conclusion Spinal cord lesions are common in KSS. Patients with spinal disease show higher disability than patients without spinal cord lesions, supporting the inclusion of dedicated acquisitions to routine MRI of the brain in patients with KSS.

Frequency of Spinal Cord Involvement and Autoantibody Status in a Large Cohort of Children Presenting with a First Acute Demyelinating Syndrome

2019 ◽  
Author(s):  
Ines El Naggar ◽  
Eva-Maria Wendel ◽  
Christian Lechner ◽  
Kathrin Schanda ◽  
Michael Karenfort ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Large Cohort ◽  
Spinal Cord Involvement ◽  
Autoantibody Status

Spinal cord involvement and paroxysmal events in “Infantile Onset Transient Hypomyelination” due to TMEM63A mutation

2021 ◽  
Author(s):  
Davide Tonduti ◽  
Eleonora Mura ◽  
Silvia Masnada ◽  
Enrico Bertini ◽  
Chiara Aiello ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Involvement

scholarly journals Axonal damage in spinal cord is associated with gray matter atrophy in sensorimotor cortex in experimental autoimmune encephalomyelitis

2019 ◽  
Vol 26 (3) ◽  
pp. 294-303 ◽  
Author(s):  
Cassandra E Meyer ◽  
Josephine L Gao ◽  
James Ying-Jie Cheng ◽  
Mandavi R Oberoi ◽  
Hadley Johnsonbaugh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Gray Matter ◽  
Sensorimotor Cortex ◽  
Axonal Damage ◽  
Strongly Correlated ◽  
Autoimmune Encephalomyelitis ◽  
Normal Controls ◽  
Experimental Autoimmune

Background: Gray matter (GM) atrophy in brain is one of the best predictors of long-term disability in multiple sclerosis (MS), and recent findings have revealed that localized GM atrophy is associated with clinical disabilities. GM atrophy associated with each disability mapped to a distinct brain region, revealing a disability-specific atlas (DSA) of GM loss. Objective: To uncover the mechanisms underlying the development of localized GM atrophy. Methods: We used voxel-based morphometry (VBM) to evaluate localized GM atrophy and Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging-compatible Tissue-hYdrogel (CLARITY) to evaluate specific pathologies in mice with experimental autoimmune encephalomyelitis (EAE). Results: We observed extensive GM atrophy throughout the cerebral cortex, with additional foci in the thalamus and caudoputamen, in mice with EAE compared to normal controls. Next, we generated pathology-specific atlases (PSAs), voxelwise mappings of the correlation between specific pathologies and localized GM atrophy. Interestingly, axonal damage (end-bulbs and ovoids) in the spinal cord strongly correlated with GM atrophy in the sensorimotor cortex of the brain. Conclusion: The combination of VBM with CLARITY in EAE can localize GM atrophy in brain that is associated with a specific pathology in spinal cord, revealing a PSA of GM loss.

Sign in / Sign up

Export Citation Format

Share Document