Neuroimaging Functional Magnetic Resonance Imaging Task‐Based Dorsolateral Prefrontal Cortex Activation Following 12 Weeks of Cosmos caudatus Supplementation Among Older Adults With Mild Cognitive Impairment

2021 ◽  
Author(s):  
Yee Xing You ◽  
Suzana Shahar ◽  
Mazlyfarina Mohamad ◽  
Nor Fadilah Rajab ◽  
Hasnah Haron ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Older Adults ◽  
Cognitive Impairment ◽  
Prefrontal Cortex ◽  
Mild Cognitive Impairment ◽  
Dorsolateral Prefrontal Cortex ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Cosmos Caudatus ◽  
Dorsolateral Prefrontal

scholarly journals Abnormal Functional Connectivity of the Amygdala in Mild Cognitive Impairment Patients With Depression Symptoms Revealed by Resting-State fMRI

2021 ◽  
Vol 12 ◽  
Author(s):  
Ting Yang ◽  
Bangli Shen ◽  
Aiqin Wu ◽  
Xinglu Tang ◽  
Wei Chen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cognitive Impairment ◽  
Prefrontal Cortex ◽  
Mild Cognitive Impairment ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Resting State ◽  
Depression Symptoms ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging

Convergent evidence indicates that individuals with symptoms of depression exhibit altered functional connectivity (FC) of the amygdala, which is a key brain region in processing emotions. At present, the characteristics of amygdala functional circuits in patients with mild cognitive impairment (MCI) with and without depression are not clear. The current study examined the features of amygdala FC in patients with MCI with depression symptoms (D-MCI) using resting-state functional magnetic resonance imaging. We acquired resting-state functional magnetic resonance imaging data from 16 patients with D-MCI, 18 patients with MCI with no depression (nD-MCI), and 20 healthy controls (HCs) using a 3T scanner and compared the strength of amygdala FC between the three groups. Patients with D-MCI exhibited significant FC differences in the amygdala–medial prefrontal cortex and amygdala–sensorimotor networks. These results suggest that the dysfunction of the amygdala–medial prefrontal cortex network and the amygdala–sensorimotor network might be involved in the neural mechanism underlying depression in MCI.

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