scholarly journals Small‐World Networks and Their Relationship With Hippocampal Glutamine/Glutamate Concentration in Healthy Adults With Varying Genetic Risk for Alzheimer's Disease

2021 ◽  
Author(s):  
Hui Zhang ◽  
Pui W. Chiu ◽  
Isaac Ip ◽  
Tianyin Liu ◽  
Gloria H.Y. Wong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Risk ◽  
Small World ◽  
Healthy Adults ◽  
Small World Networks ◽  
Glutamate Concentration

scholarly journals Small-World Networks and Functional Connectivity in Alzheimer's Disease

2006 ◽  
Vol 17 (1) ◽  
pp. 92-99 ◽  
Author(s):  
C. Stam ◽  
B. Jones ◽  
G Nolte ◽  
M Breakspear ◽  
P. Scheltens
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Small World ◽  
Small World Networks

scholarly journals Loss of ‘Small-World’ Networks in Alzheimer's Disease: Graph Analysis of fMRI Resting-State Functional Connectivity

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e13788 ◽  
Author(s):  
Ernesto J. Sanz-Arigita ◽  
Menno M. Schoonheim ◽  
Jessica S. Damoiseaux ◽  
Serge A. R. B. Rombouts ◽  
Erik Maris ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Resting State ◽  
Small World ◽  
Graph Analysis ◽  
Small World Networks ◽  
Resting State Functional Connectivity

scholarly journals Interaction of Alzheimer’s Disease-Associated Genetic Risk with Indicators of Socioeconomic Position on Mild Cognitive Impairment in the Heinz Nixdorf Recall Study

2021 ◽  
pp. 1-11
Author(s):  
Mirjam Frank ◽  
Jonas Hensel ◽  
Lisa Baak ◽  
Sara Schramm ◽  
Nico Dragano ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Socioeconomic Position ◽  
Genetic Risk ◽  
Late Onset ◽  
Heinz Nixdorf Recall Study ◽  
Low Education ◽  
Additive Scale

Background: The apolipoprotein E (APOE) ɛ4 allele is reported to be a strong genetic risk factor for mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Additional genetic loci have been detected that influence the risk for late-onset AD. As socioeconomic position (SEP) is also strongly related to cognitive decline, SEP has been suggested to be a possible modifier of the genetic effect on MCI. Objective: To investigate whether APOE ɛ4 and a genetic sum score of AD-associated risk alleles (GRSAD) interact with SEP indicators to affect MCI in a population-based cohort. Methods: Using data of 3,834 participants of the Heinz Nixdorf Recall Study, APOE ɛ4 and GRSAD by SEP interactions were assessed using logistic regression models, as well as SEP-stratified genetic association analysis. Interaction on additive scale was calculated using the relative excess risk due to interaction (RERI). All analysis were additionally stratified by sex. Results: Indication for interaction on the additive scale was found between APOE ɛ4 and low education on MCI (RERI: 0.52 [95% -confidence interval (CI): 0.01; 1.03]). The strongest genetic effects of the APOE ɛ4 genotype on MCI were observed in groups of low education (Odds ratio (OR): 1.46 [95% -CI: 0.79; 2.63] for≤10 years of education versus OR: 1.00 [95% -CI: 0.43; 2.14] for≥18 years of education). Sex stratified results showed stronger effects in women. No indication for interaction between the GRSAD and SEP indicators on MCI was observed. Conclusion: Results indicate that low education may have an impact on APOE ɛ4 expression on MCI, especially among women.

scholarly journals Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis

2015 ◽  
Vol 112 (38) ◽  
pp. 11965-11970 ◽  
Author(s):  
Li Zhu ◽  
Minghao Zhong ◽  
Gregory A. Elder ◽  
Mary Sano ◽  
David M. Holtzman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Deficits ◽  
Genetic Risk ◽  
Primary Neurons ◽  
Loss Of Function ◽  
Sporadic Alzheimer’S Disease ◽  
Postmortem Human Brain ◽  
Apoe4 Allele ◽  
Synaptojanin 1

The apolipoprotein E4 (ApoE4) allele is the strongest genetic risk factor for developing sporadic Alzheimer’s disease (AD). However, the mechanisms underlying the pathogenic nature of ApoE4 are not well understood. In this study, we have found that ApoE proteins are critical determinants of brain phospholipid homeostasis and that the ApoE4 isoform is dysfunctional in this process. We have found that the levels of phosphoinositol biphosphate (PIP2) are reduced in postmortem human brain tissues of ApoE4 carriers, in the brains of ApoE4 knock-in (KI) mice, and in primary neurons expressing ApoE4 alleles compared with those levels in ApoE3 counterparts. These changes are secondary to increased expression of a PIP2-degrading enzyme, the phosphoinositol phosphatase synaptojanin 1 (synj1), in ApoE4 carriers. Genetic reduction of synj1 in ApoE4 KI mouse models restores PIP2 levels and, more important, rescues AD-related cognitive deficits in these mice. Further studies indicate that ApoE4 behaves similar to ApoE null conditions, which fails to degrade synj1 mRNA efficiently, unlike ApoE3 does. These data suggest a loss of function of ApoE4 genotype. Together, our data uncover a previously unidentified mechanism that links ApoE4-induced phospholipid changes to the pathogenic nature of ApoE4 in AD.

scholarly journals Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease

Brain ◽  
2006 ◽  
Vol 129 (11) ◽  
pp. 2984-2991 ◽  
Author(s):  
N. Brouwers ◽  
K. Sleegers ◽  
S. Engelborghs ◽  
V. Bogaerts ◽  
S. Serneels ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Genetic Risk ◽  
Precursor Protein

O1-04-06: Elevated cerebrospinal fluid amyloid-Beta42 levels in young adults at genetic risk for early-onset alzheimer's disease

2011 ◽  
Vol 7 ◽  
pp. S102-S103 ◽  
Author(s):  
Eric Reiman ◽  
Carlos Velez-Pardo ◽  
Marelene Jimenez del Rio ◽  
Margarita Giraldo ◽  
Natalia Acosta-Baena ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Young Adults ◽  
Genetic Risk ◽  
Early Onset ◽  
Early Onset Alzheimer’S Disease

scholarly journals The use of genetic risk prediction to study prodromal Alzheimer’s disease in the PISA study

2020 ◽  
Vol 16 (S2) ◽  
Author(s):  
Michelle K. Lupton ◽  
Amir Fazlollahi ◽  
Amelia Ceslis ◽  
Jurgen Fripp ◽  
Stephen Rose ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Prediction ◽  
Genetic Risk ◽  
Genetic Risk Prediction ◽  
Prodromal Alzheimer’S Disease
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