Estimation of fractional myocardial blood volume and water exchange using ferumoxytol‐enhanced magnetic resonance imaging

2020 ◽  
Author(s):  
Caroline M. Colbert ◽  
Michael A. Thomas ◽  
Ran Yan ◽  
Aleksandra Radjenovic ◽  
J. Paul Finn ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Blood Volume ◽  
Water Exchange ◽  
Resonance Imaging ◽  
Myocardial Blood Volume

scholarly journals How Stereological Analysis of Vascular Morphology Can Quantify the Blood Volume Fraction as a Marker for Tumor Vasculature: Comparison with Magnetic Resonance Imaging

2011 ◽  
Vol 32 (3) ◽  
pp. 489-501 ◽  
Author(s):  
Adriana T Perles-Barbacaru ◽  
Boudewijn PJ van der Sanden ◽  
Regine Farion ◽  
Hana Lahrech
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Rat Brain ◽  
Blood Volume ◽  
Volume Fraction ◽  
Three Dimensional ◽  
Simulated Data ◽  
Tumor Model ◽  
Tumor Vasculature ◽  
Resonance Imaging

To assess angiogenesis noninvasively in a C6 rat brain tumor model, the rapid-steady-state- T1 (RSST1) magnetic resonance imaging (MRI) method was used for microvascular blood volume fraction (BVf) quantification with a novel contrast agent gadolinium per (3,6 anhydro) α-cyclodextrin (Gd-ACX). In brain tissue contralateral to the tumor, equal BVfs were obtained with Gd-ACX and the clinically approved gadoterate meglumine (Gd-DOTA). Contrary to Gd-DOTA, which leaks out of the tumor vasculature, Gd-ACX was shown to remain vascular in the tumor tissue allowing quantification of the tumor BVf. We sought to confirm the obtained tumor BVf using an independent method: instead of using a ‘standard’ two-dimensional histologic method, we study here how vascular morphometry combined with a stereological technique can be used for three-dimensional assessment of the vascular volume fraction ( VV). The VV is calculated from the vascular diameter and length density. First, the technique is evaluated on simulated data and the healthy rat brain vasculature and is then applied to the same C6 tumor vasculature previously quantified by RSST1-MRI with Gd-ACX. The mean perfused VV and the BVf obtained by MRI in tumor regions are practically equal and the technique confirms the spatial heterogeneity revealed by MRI.

scholarly journals Cerebral Blood Flow and Blood Volume Measured by Magnetic Resonance Imaging Bolus Tracking After Acute Stroke in Pigs

Stroke ◽  
2000 ◽  
Vol 31 (8) ◽  
pp. 1958-1964 ◽  
Author(s):  
Masaharu Sakoh ◽  
Lisbeth Røhl ◽  
Carsten Gyldensted ◽  
Albert Gjedde ◽  
Leif Østergaard
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Acute Stroke ◽  
Blood Volume ◽  
Resonance Imaging ◽  
Bolus Tracking

scholarly journals Magnetic resonance imaging measurement of blood volume flow in peripheral arteries in healthy subjects

2003 ◽  
Vol 38 (5) ◽  
pp. 1060-1066 ◽  
Author(s):  
Willemijn M Klein ◽  
Lambertus W Bartels ◽  
Liesbeth Bax ◽  
Yolanda van der Graaf ◽  
Willem P.Th.M Mali
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Blood Volume ◽  
Healthy Subjects ◽  
Volume Flow ◽  
Peripheral Arteries ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Measurement
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