Ocular Blood Flow Measurements in Diabetic Retinopathy Using 3D Pseudocontinuous Arterial Spin Labeling

2020 ◽  
Author(s):  
Huihui Wang ◽  
Jiao Sun ◽  
Jing Li ◽  
Hongyang Li ◽  
Yanling Wang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Ocular Blood Flow ◽  
Flow Measurements ◽  
Blood Flow Measurements

Mouse lumbar and cervical spinal cord blood flow measurements by arterial spin labeling: Sensitivity optimization and first application

2009 ◽  
Vol 62 (2) ◽  
pp. 430-439 ◽  
Author(s):  
Guillaume Duhamel ◽  
Virginie Callot ◽  
Patrick Decherchi ◽  
Yann Le Fur ◽  
Tanguy Marqueste ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Arterial Spin Labeling ◽  
Cervical Spinal Cord ◽  
Spin Labeling ◽  
Spinal Cord Blood Flow ◽  
Flow Measurements ◽  
Blood Flow Measurements

Cerebral blood flow measurements in infants using look-locker arterial spin labeling

2014 ◽  
Vol 41 (6) ◽  
pp. 1591-1600 ◽  
Author(s):  
Marta Varela ◽  
Esben T. Petersen ◽  
Xavier Golay ◽  
Joseph V. Hajnal
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Flow Measurements ◽  
Blood Flow Measurements

scholarly journals Prognostic Value of Blood Flow Measurements Using Arterial Spin Labeling in Gliomas

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99616 ◽  
Author(s):  
Julia Furtner ◽  
Benjamin Bender ◽  
Christian Braun ◽  
Jens Schittenhelm ◽  
Marco Skardelly ◽  
...  
Keyword(s):  
Blood Flow ◽  
Arterial Spin Labeling ◽  
Prognostic Value ◽  
Spin Labeling ◽  
Flow Measurements ◽  
Blood Flow Measurements

scholarly journals Long-Delay Arterial Spin Labeling Provides More Accurate Cerebral Blood Flow Measurements in Moyamoya Patients

Stroke ◽  
2017 ◽  
Vol 48 (9) ◽  
pp. 2441-2449 ◽  
Author(s):  
Audrey P. Fan ◽  
Jia Guo ◽  
Mohammad M. Khalighi ◽  
Praveen K. Gulaka ◽  
Bin Shen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Flow Measurements ◽  
Blood Flow Measurements

scholarly journals Non-invasive Diagnosis and Prognosis Values of 3D Pseudocontinuous Arterial Spin Labeling and Optical Coherence Tomography Angiography in Proliferative Diabetic Retinopathy

2021 ◽  
Vol 8 ◽  
Author(s):  
Yanli Hou ◽  
Shuai Song ◽  
Jiao Sun ◽  
Huihui Wang ◽  
Yanling Wang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Arterial Spin Labeling ◽  
Optical Coherence Tomography Angiography ◽  
Spin Labeling ◽  
Ocular Blood Flow ◽  
Non Invasive ◽  
Peripapillary Area

Background: 3D Pseudocontinuous Arterial Spin Labeling (3D-PCASL) MRI and optical coherence tomography angiography (OCTA) have been applied to detect ocular blood flow (BF). We aim to characterize the ocular BF in diabetic retinopathy (DR) using 3D-PCASL and OCTA, to discuss the relationship between ocular and cerebral BF, and to evaluate their potential utility to assess the severity of DR.Methods: A total of 66 participants (132 eyes) were included. Seventy-two eyes were classified in the proliferative diabetic retinopathy (PDR) group, and 60 were in the non-proliferative diabetic retinopathy NPDR group. Ocular and cerebral BF values were detected by 3D-PCASL using a 3.0T MRI scanner with two post-labeling delays (PLDs). Vessel density (VD)/perfusion density (PD) of the macular or peripapillary area were detected by OCTA. Parameters and clinical characteristics were compared between the PDR and NPDR eyes utilizing two-sample t-tests and chi-square tests. Spearman's rank correlation analysis, logistic regression analysis, and receiver operating characteristic curves (ROC) analyses were performed to evaluate the factors' role in DR severity.Results: The perfusions of the retinal/choroidal plexus (RCP), optic nerve head (ONH)/optic nerve (ON), and VD/PD of macular/peripapillary area in the PDR group were significantly lower compared to the NPDR group (p < 0.05). They were protective factors for PDR [ORs = 0.842 for RCP (1.5 s PLD), 0.910 for ONH (1.5 s PLD), 0.905 for ON (both 1.5 and 2.5 s PLD), 0.707 for macular VD, 0.652 for peripapillary VD, p < 0.05, respectively]. Ocular BF had a positive correlation with BF of the occipital lobe (OL) and temporal lobe (TL) in the cerebrum. The BF of RCP (lower than 7.825 mL/min/100 g at 1.5 s PLD) indicated PDR [areas under the curve (AUCs) = 0.682, 95% CI: 0.588–0.777, sensitivity: 70.7% specificity: 63.9%]. The AUC of RCP (PLD = 1.5 s) BF combined with peripapillary VD was 0.841 (95% CI: 0.588–0.777, sensitivity: 75.9% specificity: 82.9%).Conclusions: 3D-pcASL and OCTA may be effective non-invasive methods to measure ocular blood flow in DR patients and assess the severity of DR.

scholarly journals Unilateral fetal-type circle of Willis anatomy causes right–left asymmetry in cerebral blood flow with pseudo-continuous arterial spin labeling: A limitation of arterial spin labeling-based cerebral blood flow measurements?

2016 ◽  
Vol 36 (9) ◽  
pp. 1570-1578 ◽  
Author(s):  
Jurriaan JH Barkeij Wolf ◽  
Jessica C Foster-Dingley ◽  
Justine EF Moonen ◽  
Matthias JP van Osch ◽  
Anton JM de Craen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Velocity ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Circle Of Willis ◽  
Flow Measurements ◽  
Blood Flow Signal ◽  
Continuous Arterial Spin Labeling ◽  
Blood Flow Measurements

The accuracy of cerebral blood flow measurements using pseudo-continuous arterial spin labeling can be affected by vascular factors other than cerebral blood flow, such as flow velocity and arterial transit time. We aimed to elucidate the effects of common variations in vascular anatomy of the circle of Willis on pseudo-continuous arterial spin labeling signal. In addition, we investigated whether possible differences in pseudo-continuous arterial spin labeling signal could be mediated by differences in flow velocities. Two hundred and three elderly participants underwent magnetic resonance angiography of the circle of Willis and pseudo-continuous arterial spin labeling scans. Mean pseudo-continuous arterial spin labeling-cerebral blood flow signal was calculated for the gray matter of the main cerebral flow territories. Mean cerebellar gray matter pseudo-continuous arterial spin labeling-cerebral blood flow was significantly lower in subjects having a posterior fetal circle of Willis variant with an absent P1 segment. The posterior fetal circle of Willis variants also showed a significantly higher pseudo-continuous arterial spin labeling-cerebral blood flow signal in the ipsilateral flow territory of the posterior cerebral artery. Flow velocity in the basilar artery was significantly lower in these posterior fetal circle of Willis variants. This study indicates that pseudo-continuous arterial spin labeling measurements underestimate cerebral blood flow in the posterior flow territories and cerebellum of subjects with a highly prevalent variation in circle of Willis morphology. Additionally, our data suggest that this effect is mediated by concomitant differences in flow velocity between the supplying arteries.

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