scholarly journals DTI Tract‐Based Quantitative Susceptibility Mapping: An Initial Feasibility Study to Investigate the Potential Role of Myelination in Brain Connectivity Change in Cerebral Palsy Patients During Autologous Cord Blood Cell Therapy Using a Rotationally‐Invariant Quantitative Measure

2020 ◽  
Vol 53 (1) ◽  
pp. 251-258
Author(s):  
Lijia Zhang ◽  
Susan Ellor ◽  
Jessica M. Sun ◽  
Chunlei Liu ◽  
Joanne Kurtzburg ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Cell Therapy ◽  
Blood Cell ◽  
Potential Role ◽  
Brain Connectivity ◽  
Quantitative Measure ◽  
Quantitative Susceptibility Mapping ◽  
Cord Blood Cell ◽  
Rotationally Invariant

Involvement of Immune Responses in the Efficacy of Cord Blood Cell Therapy for Cerebral Palsy

2015 ◽  
Vol 24 (19) ◽  
pp. 2259-2268 ◽  
Author(s):  
Mino Kang ◽  
Kyunghoon Min ◽  
Joonyoung Jang ◽  
Seung Chan Kim ◽  
Myung Seo Kang ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Cell Therapy ◽  
Immune Responses ◽  
Blood Cell ◽  
Cord Blood ◽  
Cord Blood Cell

The prevention of cerebral palsy in preterm infants – the potential role of magnesium sulfate

2019 ◽  
Vol 4 (67) ◽  
pp. 180
Author(s):  
Adelina Staicu ◽  
Adela Hanga ◽  
Ioana C. Rotar ◽  
Gabriela C. Zaharie ◽  
Daniel Mureşan
Keyword(s):  
Cerebral Palsy ◽  
Magnesium Sulfate ◽  
Preterm Infants ◽  
Potential Role

scholarly journals The potential role of the red blood cell in nitrite-dependent regulation of blood flow

2010 ◽  
Vol 89 (3) ◽  
pp. 507-515 ◽  
Author(s):  
Rakesh P. Patel ◽  
Neil Hogg ◽  
Daniel B. Kim-Shapiro
Keyword(s):  
Blood Flow ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Potential Role

Response to ‘Classification of cerebral palsy and potential role of video recording’

2018 ◽  
Vol 22 (1) ◽  
pp. 211-212
Author(s):  
Hendriekje Eggink ◽  
Daan Kremer ◽  
Marina A.J. Tijssen
Keyword(s):  
Cerebral Palsy ◽  
Potential Role ◽  
Video Recording

scholarly journals Single group multisite safety trial of sibling cord blood cell infusion to children with cerebral palsy: study protocol and rationale

BMJ Open ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. e034974
Author(s):  
Kylie Crompton ◽  
Iona Novak ◽  
Michael Fahey ◽  
Nadia Badawi ◽  
Euan Wallace ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Blood Cell ◽  
Cord Blood ◽  
Preliminary Evidence ◽  
Fine Motor ◽  
Life Outcomes ◽  
Single Group ◽  
Human Research Ethics ◽  
Cord Blood Cell ◽  
Registration Number

IntroductionCerebral palsy (CP) is the most common physical disability of childhood but has no cure. Stem cells have the potential to improve brain injury and are proposed as a therapy for CP. However, many questions remain unanswered about the most appropriate cell type, timing of infusions, dose required and associated risks. Therefore, human safety and efficacy trials are necessary to progress knowledge in the field.Methods and analysisThis is a single group study with sample size n=12 to investigate safety of single-dose intravenous 12/12 human leucocyte antigen-matched sibling cord blood cell infusion to children with CP aged 1–16 years without immune suppression. The study is similar to a 3+3 design, where the first two groups of participants have severe CP, and the final six participants include children with all motor severities. Children will be monitored for adverse events and the duration that donor cells are detected. Assessments at baseline, 3 and 12 months will investigate safety and preliminary evidence of change in gross motor, fine motor, cognitive and quality of life outcomes.Ethics and disseminationFull approval was obtained from The Royal Children’s Hospital Human Research Ethics Committee, and a clinical trial notification was accepted by Australia’s Therapeutic Goods Administration. Participant guardian informed consent will be obtained before any study procedures. The main results of this study will be submitted for publication in a peer-reviewed journal.Trial registration numberACTRN12616000403437,NCT03087110.

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