Editorial for “Multiparametric MRI Radiomic Model for Preoperative Predicting WHO / ISUP Nuclear Grade of Clear Cell Renal Cell Carcinoma”

2020 ◽  
Vol 52 (5) ◽  
pp. 1567-1568
Author(s):  
Alexandra A. Ntorkou
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Multiparametric Mri ◽  
Nuclear Grade ◽  
Cell Renal Cell Carcinoma

Utility of the Apparent Diffusion Coefficient for Distinguishing Clear Cell Renal Cell Carcinoma of Low and High Nuclear Grade

2010 ◽  
Vol 195 (5) ◽  
pp. W344-W351 ◽  
Author(s):  
Andrew B. Rosenkrantz ◽  
Benjamin E. Niver ◽  
Erin F. Fitzgerald ◽  
James S. Babb ◽  
Hersh Chandarana ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Nuclear Grade ◽  
Cell Renal Cell Carcinoma ◽  
High Nuclear Grade ◽  
Apparent Diffusion

Overexpression of IL-32 as a novel prognostic factor in patients with clear cell renal cell carcinoma after a nephrectomy.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 413-413
Author(s):  
Hyo Jin Lee ◽  
Hyun-Jung Lee ◽  
Zhe Long Liang ◽  
Jae-Sung Lim ◽  
Jin Man Kim
Keyword(s):  
Renal Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Survival Rates ◽  
Staining Intensity ◽  
Nuclear Grade ◽  
Recurrence Rates ◽  
Cell Renal Cell Carcinoma

413 Background: Interleukin-32 (IL-32) is a proinflammatory cytokine, which acts as an important pathogenetic factor in various diseases and malignancies. However, the clinical significance of IL-32 expression in renal cell carcinoma has not been previously investigated. Methods: We examined 112 patients with localized clear cell renal cell carcinoma (CCRCC) who underwent nephrectomy. The clinicopathologic data were obtained by retrospective review and the expression levels of IL-32 were studied by immunohistochemistry. Tumors were classified into four scores based on the staining intensity (0, no staining intensity; 1, weak; 2, intermediate; 3, strong). The cases with staining intensities from 0 to 2 were included in the IL-32 low expression group (LEG); whereas, those with staining intensity of 3 were considered the IL-32 high expression group (HEG). Correlations between IL-32 expression and clinicopathologic features were determined. Results: Staining intensities were determined for all cases as follows: 26 cases (23.2%) (score 0), 43 cases (38.4%) (score 1), 31 cases (27.7%) (score 2), and 12 cases (10.7%) (score 3). IL-32 HEG showed a higher recurrence rate compared to the IL-32 LEG (50% vs. 13%, P=0.001). For survival rates, the 5-year recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS) rates were lower in the IL-32 HEG compared with the IL-32 LEG (RFS, 87% vs. 50%, P = 0.001; DSS, 92% vs. 58.3%, P < 0.001; OS, 84% vs. 58.3%, P = 0.026, respectively). Univariate analyses showed that Fuhrman nuclear grade and high IL-32 expression were significant prognostic factors for predicting RFS, DSS, and OS in CCRCC; while, multivariate analyses indicated Fuhrman nuclear grade and high IL-32 expression (RFS, HR, 4.932, P = 0.009; DSS, HR 6.736, P = 0.002; OS, HR, 2.992, P = 0.037, respectively) were still independent risk factors. Conclusions: IL-32 overexpression was associated with high recurrence rates and low RFS, DSS, and OS, suggesting that it could be a novel prognostic factor for predicting outcomes in patients with CCRCC after a nephrectomy.

scholarly journals Evaluation of Ki67 Expression in Relation to Tumor Stage and Fuhrman Nuclear Grade of Renal Cell Carcinoma and MUC1 Expression in Clear Cell Renal Cell Carcinoma

2021 ◽  
Vol 10 (33) ◽  
pp. 2718-2722
Author(s):  
Sarumathy Ganesan ◽  
Prathiba Arumugam ◽  
Nithya Ilanchezhian ◽  
Saraswathi Manickam
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Labelling Index ◽  
Nuclear Grade ◽  
Muc1 Expression ◽  
Cell Renal Cell Carcinoma ◽  
Ki67 Expression ◽  
Clear Cell Rcc

BACKGROUND Renal cell carcinoma (RCC) is the most common malignant renal tumour in adults. Prognosis of RCC depends on various factors like tumour stage, nuclear grade and histological type. For planning adjuvant therapy, accurate prediction of prognosis is mandatory. In many studies, ki67 and MUC1 has shown to be of prognostic significance and immunohistochemical expression of these two markers plays an important role in determining the prognosis of RCC. The purpose of this study was to evaluate the Ki67 expression in histologically confirmed cases of RCC and MUC1 expression in clear cell renal cell carcinoma, and to correlate them with the stage and Fuhrman nuclear grade of the tumour, in order to determine their role as prognostic markers in RCC. METHODS This study was a retrospective study. A total of 50 specimens of renal cell carcinoma were studied. The specimens were total and partial nephrectomy done in the department of urology for a period of 3 years. Expression of Ki67 and MUC1 in RCC were studied by immunohistochemistry (IHC). Statistical analysis was performed and P value < 0.05 was considered significant. RESULTS Out of 50 RCC studied, Ki67 labelling index ≥ 15 % was found in 35 cases. For MUC1, immunoreactivity of more than 10 % of tumor cell was found in 28/34 of clear cell RCC. In this study, Ki67 labelling index showed statistically significant expression with the stage of tumor and the nuclear grade. MUC1 expression also showed significant correlation with nuclear grade and stage of clear cell RCC. CONCLUSIONS High Ki67 labelling index in renal cell carcinoma is seen to correlate with higher nuclear grade and stage of tumor. High level expression with circumferential staining pattern of MUC1 is seen in high grade tumours with increased risk of metastasis. So MUC1 and Ki67 can be considered as a marker of prognosis of RCC. KEY WORDS Renal Cell Carcinoma, Immunohistochemistry, Ki67, MUC1

Organ-confined clear cell renal cell carcinoma: the prognostic impact of microvascular invasion, nuclear grade and tumour size

Apmis ◽  
2008 ◽  
Vol 116 (12) ◽  
pp. 1027-1033 ◽  
Author(s):  
D. P. ZUBAC ◽  
L. BOSTAD ◽  
B. KIHL ◽  
J. EIDE ◽  
T. WENTZEL-LARSEN ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Tumour Size ◽  
Microvascular Invasion ◽  
Nuclear Grade ◽  
Prognostic Impact ◽  
Cell Renal Cell Carcinoma

MP50-08 DIFFUSION-WEIGHTED MRI AS AN IMAGING BIOMARKER OF THE FUHRMAN NUCLEAR GRADE OF CLEAR CELL RENAL CELL CARCINOMA

2020 ◽  
Vol 203 ◽  
pp. e755
Author(s):  
Koki Mitani* ◽  
Soichiro Yoshida ◽  
Yusuke Uchida ◽  
Tsuyoshi Sakamoto ◽  
Hajime Tanaka ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Nuclear Grade ◽  
Imaging Biomarker ◽  
Diffusion Weighted Mri ◽  
Cell Renal Cell Carcinoma ◽  
Diffusion Weighted
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