Monitoring of acoustic cavitation in microbubble‐presented focused ultrasound exposure using gradient‐echo MRI

2019 ◽  
Vol 51 (1) ◽  
pp. 311-318 ◽  
Author(s):  
Chen‐Hua Wu ◽  
Hao‐Li Liu ◽  
Cheng‐Tao Ho ◽  
Po‐Hung Hsu ◽  
Ching‐Hsiang Fan ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Acoustic Cavitation ◽  
Gradient Echo ◽  
Ultrasound Exposure

Effekt of blood flow shutdown on the vein damage when exposed to HIFU

2017 ◽  
pp. 46-50
Author(s):  
Н.Н. Петрищев ◽  
Д.Ю. Семенов ◽  
А.Ю. Цибин ◽  
Г.Ю. Юкина ◽  
А.Е. Беркович ◽  
...  
Keyword(s):  
Blood Flow ◽  
Structural Changes ◽  
Focused Ultrasound ◽  
Vena Cava ◽  
Posterior Wall ◽  
High Intensity Focused Ultrasound ◽  
Vein Wall ◽  
Ultrasound Exposure ◽  
Isolated Segment ◽  
The Impact

The purpose. In the study we investigated the impact of the partial blood flow shutdown on structural changes in the rabbit vena cava posterior wall after exposure to high-intensity focused ultrasound (HIFU). Methods. Ultrasound Exposure: frequency of 1.65 MHz, the ultrasound intensity in the focus of 13.6 kW/cm, the area of the focal spot 1 mm, continuous ultrasound, exposure for 3 seconds. Results. Immediately after HIFU exposure all layers of the vein wall showed characteristic signs of thermal damage. A week after exposure structural changes in the intima, media and adventitia was minimal in the part of vessel with preserved blood flow, and after 4 weeks the changes were not revealed. A week after HIFU exposure partial endothelium destruction, destruction of myocytes, disorganization and consolidation of collagen fibers of the adventitia were observed in an isolated segment of the vessel, and in 4 weeks endothelium restored and signs of damage in media and adventitia persisted, but were less obvious than in a week after exposure. Conclusion. The shutdown of blood flow after exposure to HIFU promotes persistent changes in the vein wall. Vein compression appears to be necessary for the obliteration of the vessel, when using HIFU-technology.

scholarly journals Microscale concert hall acoustics to produce uniform ultrasound stimulation for targeted sonogenetics in hsTRPA1-transfected cells

2021 ◽  
Author(s):  
Aditya Vasan ◽  
Florian Allein ◽  
Marc Duque ◽  
Uri Magaram ◽  
Nicholas Boechler ◽  
...  
Keyword(s):  
Acoustic Waves ◽  
Focused Ultrasound ◽  
Electrical Response ◽  
Fold Increase ◽  
Normal Brain ◽  
Ultrasound Exposure ◽  
Ultrasound Stimulation ◽  
Normal Brain Function ◽  
Ultrasound Intensity ◽  
The Brain

The field of ultrasound neuromodulation has rapidly developed over the past decade, a consequence of the discovery of strain-sensitive structures in the membrane and organelles of cells extending into the brain, heart, and other organs. Notably, clinical trials are underway for treating epilepsy using focused ultrasound to elicit an organized local electrical response. A key limitation to this approach is the formation of standing waves within the skull. In standing acoustic waves, the maximum ultrasound intensity spatially varies from near zero to double the mean in one half a wavelength, and can lead to localized tissue damage and disruption of normal brain function while attempting to evoke a broader response. This phenomenon also produces a large spatial variation in the actual ultrasound exposure in tissue, leading to heterogeneous results and challenges with interpreting these effects. One approach to overcome this limitation is presented herein: transducer-mounted diffusers that result in spatiotemporally incoherent ultrasound. The signal is numerically and experimentally quantified in an enclosed domain with and without the diffuser. Specifically, we show that adding the diffuser leads to a two-fold increase in ultrasound responsiveness of hsTRPA1 transfected HEK cells. Furthermore, we demonstrate the diffuser allow us to produce an uniform spatial distribution of pressure in the rodent skull. Collectively, we propose that our approach leads to a means to deliver uniform ultrasound into irregular cavities for sonogenetics.

Multi-gradient echo MR thermometry for monitoring of the near-field area during MR-guided high intensity focused ultrasound heating

2015 ◽  
Vol 60 (19) ◽  
pp. 7729-7746 ◽  
Author(s):  
Mie K Lam ◽  
Martijn de Greef ◽  
Job G Bouwman ◽  
Chrit T W Moonen ◽  
Max A Viergever ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Near Field ◽  
High Intensity Focused Ultrasound ◽  
Gradient Echo ◽  
Mr Thermometry ◽  
Field Area

scholarly journals Nanoparticle-Mediated Acoustic Cavitation Enables High Intensity Focused Ultrasound Ablation Without Tissue Heating

2018 ◽  
Vol 10 (43) ◽  
pp. 36786-36795 ◽  
Author(s):  
Adem Yildirim ◽  
Dennis Shi ◽  
Shambojit Roy ◽  
Nicholas T. Blum ◽  
Rajarshi Chattaraj ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Acoustic Cavitation ◽  
High Intensity Focused Ultrasound ◽  
Tissue Heating ◽  
Ultrasound Ablation ◽  
Focused Ultrasound Ablation

scholarly journals Development of a High-intensity Focused Ultrasound Exposure Device for Reducing Skin Burn Risk

2020 ◽  
Vol 32 (1) ◽  
pp. 1-9
Author(s):  
Shogo NISHII ◽  
Kohei SEO ◽  
Aleksander Tatsuya IZDEBSKI ◽  
Miki KUSHIMA ◽  
Ryo TAKAGI ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Skin Burn ◽  
Ultrasound Exposure

scholarly journals Laser-nucleated acoustic cavitation in focused ultrasound

2011 ◽  
Vol 82 (4) ◽  
pp. 044902 ◽  
Author(s):  
Bjoern Gerold ◽  
Spiros Kotopoulis ◽  
Craig McDougall ◽  
David McGloin ◽  
Michiel Postema ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Acoustic Cavitation
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