scholarly journals Liver fibrosis imaging: A clinical review of ultrasound and magnetic resonance elastography

2019 ◽  
Vol 51 (1) ◽  
pp. 25-42 ◽  
Author(s):  
Yingzhen N. Zhang ◽  
Kathryn J. Fowler ◽  
Arinc Ozturk ◽  
Chetan K. Potu ◽  
Ashley L. Louie ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Liver Fibrosis ◽  
Clinical Review ◽  
Magnetic Resonance Elastography

Abstract 12308: Assessment of Liver Fibrosis Using Magnetic Resonance Elastography in Children Who Undergo the Fontan Procedure and Intracardiac Repair

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Masaya Sugimoto ◽  
Hideharu Oka ◽  
Aya Kajihama ◽  
Kouichi Nakau ◽  
Hiroshi Azuma
Keyword(s):  
Magnetic Resonance ◽  
Liver Fibrosis ◽  
Fontan Procedure ◽  
Venous Pressure ◽  
Liver Stiffness ◽  
Magnetic Resonance Elastography ◽  
Cardiac Biomarkers ◽  
Control Group ◽  
Intracardiac Repair ◽  
Significant Difference

Background: The incidence of late complications related to the liver such as fibrosis/cirrhosis is increasing in patients who have undergone the Fontan procedure and may contribute to morbidity and mortality. Recently, magnetic resonance elastography (MRE), a novel evaluation technique of liver fibrosis, has been attracting attention. However, few reports have described the use of MRE for evaluating liver fibrosis in children with congenital heart disease (CHD). Methods: Thirty-two children were examined and divided into 4 groups: 12 children with CHD who underwent intracardiac repair (ICR; median age, 13.0 years); 10 with CHD who underwent the Fontan procedure (Fontan; 15.3 years); 8 who were included in the control group (control; 15.8 years); and 2 children with cirrhosis (cirrhosis; 16.3 years). The liver stiffness (LS) was estimated by MRE. LS was measured 3 times consecutively, and the mean value was considered for further analysis. Central venous pressure (CVP) and cardiac index (C.I.) were determined by cardiac catheterization. The levels of cardiac biomarkers (NTproBNP and PIIIP) were determined at the same time. Results: Among the 4 groups, no significant differences were observed in age, C.I., and NTproBNP levels. The PIIIP levels in the cirrhosis group were significantly higher than those in the control, but no significant difference in PIIIP levels was found among the other groups (p < 0.01). LS in the Fontan and cirrhosis group was significantly higher than that in the control group (5.6, 15.3 vs. 2.4 kPa, respectively; Fig. 1). Furthermore, there was a strong correlation between LS and CVP (r = 0.802; Fig. 2). Conclusions: This study showed that LS is a direct function of CVP, which should be considered when assessing the degree of liver fibrosis in children with CHD. In particular, in the case of children who undergo the Fontan procedure, the highly sensitive MRE can be used to evaluate liver fibrosis and help detect LS earlier than cardiac biomarkers do.

scholarly journals Validation and Refinement of Noninvasive Methods to Assess Hepatic Fibrosis: Magnetic Resonance Elastography Versus Enhanced Liver Fibrosis Index

2019 ◽  
Vol 65 (4) ◽  
pp. 1252-1257 ◽  
Author(s):  
Kenneth E. Sherman ◽  
Enass A. Abdel-Hameed ◽  
Richard L. Ehman ◽  
Susan D. Rouster ◽  
Adriana Campa ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Liver Fibrosis ◽  
Hepatic Fibrosis ◽  
Magnetic Resonance Elastography ◽  
Noninvasive Methods ◽  
Liver Fibrosis Index

scholarly journals A prediction model for the grade of liver fibrosis using magnetic resonance elastography

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Yusuke Mitsuka ◽  
Yutaka Midorikawa ◽  
Hayato Abe ◽  
Naoki Matsumoto ◽  
Mitsuhiko Moriyama ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Liver Fibrosis ◽  
Prediction Model ◽  
Magnetic Resonance Elastography

Magnetic resonance elastography is as accurate as liver biopsy for liver fibrosis staging

2017 ◽  
Vol 47 (5) ◽  
pp. 1268-1275 ◽  
Author(s):  
Hiroyuki Morisaka ◽  
Utaroh Motosugi ◽  
Shintaro Ichikawa ◽  
Tadao Nakazawa ◽  
Tetsuo Kondo ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Liver Fibrosis ◽  
Liver Biopsy ◽  
Magnetic Resonance Elastography ◽  
Fibrosis Staging
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