Transition zone prostate cancer: Logistic regression and machine-learning models of quantitative ADC, shape and texture features are highly accurate for diagnosis

2019 ◽  
Vol 50 (3) ◽  
pp. 940-950 ◽  
Author(s):  
Mark Wu ◽  
Satheesh Krishna ◽  
Rebecca E. Thornhill ◽  
Trevor A. Flood ◽  
Matthew D.F. McInnes ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Machine Learning ◽  
Logistic Regression ◽  
Transition Zone ◽  
Texture Features ◽  
Learning Models ◽  
Machine Learning Models

scholarly journals High performance logistic regression for privacy-preserving genome analysis

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Martine De Cock ◽  
Rafael Dowsley ◽  
Anderson C. A. Nascimento ◽  
Davis Railsback ◽  
Jianwei Shen ◽  
...  
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Genome Analysis ◽  
Local Area Network ◽  
Local Area ◽  
Activation Function ◽  
Area Network ◽  
Learning Models ◽  
Data Set ◽  
Machine Learning Models

Abstract Background In biomedical applications, valuable data is often split between owners who cannot openly share the data because of privacy regulations and concerns. Training machine learning models on the joint data without violating privacy is a major technology challenge that can be addressed by combining techniques from machine learning and cryptography. When collaboratively training machine learning models with the cryptographic technique named secure multi-party computation, the price paid for keeping the data of the owners private is an increase in computational cost and runtime. A careful choice of machine learning techniques, algorithmic and implementation optimizations are a necessity to enable practical secure machine learning over distributed data sets. Such optimizations can be tailored to the kind of data and Machine Learning problem at hand. Methods Our setup involves secure two-party computation protocols, along with a trusted initializer that distributes correlated randomness to the two computing parties. We use a gradient descent based algorithm for training a logistic regression like model with a clipped ReLu activation function, and we break down the algorithm into corresponding cryptographic protocols. Our main contributions are a new protocol for computing the activation function that requires neither secure comparison protocols nor Yao’s garbled circuits, and a series of cryptographic engineering optimizations to improve the performance. Results For our largest gene expression data set, we train a model that requires over 7 billion secure multiplications; the training completes in about 26.90 s in a local area network. The implementation in this work is a further optimized version of the implementation with which we won first place in Track 4 of the iDASH 2019 secure genome analysis competition. Conclusions In this paper, we present a secure logistic regression training protocol and its implementation, with a new subprotocol to securely compute the activation function. To the best of our knowledge, we present the fastest existing secure multi-party computation implementation for training logistic regression models on high dimensional genome data distributed across a local area network.

scholarly journals Comparison of the Performance of Machine Learning Algorithms in Predicting Heart Disease

2021 ◽  
Vol 10 (1) ◽  
pp. 99
Author(s):  
Sajad Yousefi
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Heart Disease ◽  
Decision Tree ◽  
Roc Curve ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Learning Models ◽  
Algorithm Performance ◽  
Machine Learning Models

Introduction: Heart disease is often associated with conditions such as clogged arteries due to the sediment accumulation which causes chest pain and heart attack. Many people die due to the heart disease annually. Most countries have a shortage of cardiovascular specialists and thus, a significant percentage of misdiagnosis occurs. Hence, predicting this disease is a serious issue. Using machine learning models performed on multidimensional dataset, this article aims to find the most efficient and accurate machine learning models for disease prediction.Material and Methods: Several algorithms were utilized to predict heart disease among which Decision Tree, Random Forest and KNN supervised machine learning are highly mentioned. The algorithms are applied to the dataset taken from the UCI repository including 294 samples. The dataset includes heart disease features. To enhance the algorithm performance, these features are analyzed, the feature importance scores and cross validation are considered.Results: The algorithm performance is compared with each other, so that performance based on ROC curve and some criteria such as accuracy, precision, sensitivity and F1 score were evaluated for each model. As a result of evaluation, Accuracy, AUC ROC are 83% and 99% respectively for Decision Tree algorithm. Logistic Regression algorithm with accuracy and AUC ROC are 88% and 91% respectively has better performance than other algorithms. Therefore, these techniques can be useful for physicians to predict heart disease patients and prescribe them correctly.Conclusion: Machine learning technique can be used in medicine for analyzing the related data collections to a disease and its prediction. The area under the ROC curve and evaluating criteria related to a number of classifying algorithms of machine learning to evaluate heart disease and indeed, the prediction of heart disease is compared to determine the most appropriate classification. As a result of evaluation, better performance was observed in both Decision Tree and Logistic Regression models.

scholarly journals Identification of Primary Antimicrobial Resistance Drivers in Agricultural Nontyphoidal Salmonella enterica Serovars by Using Machine Learning

mSystems ◽  
2019 ◽  
Vol 4 (4) ◽  
Author(s):  
Finlay Maguire ◽  
Muhammad Attiq Rehman ◽  
Catherine Carrillo ◽  
Moussa S. Diarra ◽  
Robert G. Beiko
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Antimicrobial Resistance ◽  
Broiler Chicken ◽  
Genomic Data ◽  
Set Covering ◽  
Learning Models ◽  
Commercial Chicken ◽  
The Impact ◽  
Machine Learning Models

ABSTRACT Nontyphoidal Salmonella (NTS) is a leading global cause of bacterial foodborne morbidity and mortality. Our ability to treat severe NTS infections has been impaired by increasing antimicrobial resistance (AMR). To understand and mitigate the global health crisis AMR represents, we need to link the observed resistance phenotypes with their underlying genomic mechanisms. Broiler chickens represent a key reservoir and vector for NTS infections, but isolates from this setting have been characterized in only very low numbers relative to clinical isolates. In this study, we sequenced and assembled 97 genomes encompassing 7 serotypes isolated from broiler chicken in farms in British Columbia between 2005 and 2008. Through application of machine learning (ML) models to predict the observed AMR phenotype from this genomic data, we were able to generate highly (0.92 to 0.99) precise logistic regression models using known AMR gene annotations as features for 7 antibiotics (amoxicillin-clavulanic acid, ampicillin, cefoxitin, ceftiofur, ceftriaxone, streptomycin, and tetracycline). Similarly, we also trained “reference-free” k-mer-based set-covering machine phenotypic prediction models (0.91 to 1.0 precision) for these antibiotics. By combining the inferred k-mers and logistic regression weights, we identified the primary drivers of AMR for the 7 studied antibiotics in these isolates. With our research representing one of the largest studies of a diverse set of NTS isolates from broiler chicken, we can thus confirm that the AmpC-like CMY-2 β-lactamase is a primary driver of β-lactam resistance and that the phosphotransferases APH(6)-Id and APH(3″-Ib) are the principal drivers of streptomycin resistance in this important ecosystem. IMPORTANCE Antimicrobial resistance (AMR) represents an existential threat to the function of modern medicine. Genomics and machine learning methods are being increasingly used to analyze and predict AMR. This type of surveillance is very important to try to reduce the impact of AMR. Machine learning models are typically trained using genomic data, but the aspects of the genomes that they use to make predictions are rarely analyzed. In this work, we showed how, by using different types of machine learning models and performing this analysis, it is possible to identify the key genes underlying AMR in nontyphoidal Salmonella (NTS). NTS is among the leading cause of foodborne illness globally; however, AMR in NTS has not been heavily studied within the food chain itself. Therefore, in this work we performed a broad-scale analysis of the AMR in NTS isolates from commercial chicken farms and identified some priority AMR genes for surveillance.

Machine-Learning Models for Multicenter Prostate Cancer Treatment Plans

2020 ◽  
Author(s):  
Khajamoinuddin Syed ◽  
William Sleeman ◽  
Payal Soni ◽  
Michael Hagan ◽  
Jatinder Palta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Machine Learning ◽  
Cancer Treatment ◽  
Learning Models ◽  
Prostate Cancer Treatment ◽  
Treatment Plans ◽  
Machine Learning Models

scholarly journals Machine learning to predict early TNF inhibitor users in patients with ankylosing spondylitis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Seulkee Lee ◽  
Yeonghee Eun ◽  
Hyungjin Kim ◽  
Hoon-Suk Cha ◽  
Eun-Mi Koh ◽  
...  
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Ankylosing Spondylitis ◽  
Tnf Inhibitor ◽  
Ann Model ◽  
Learning Models ◽  
Feature Importance ◽  
Importance Analysis ◽  
Baseline Characteristics ◽  
Machine Learning Models

AbstractWe aim to generate an artificial neural network (ANN) model to predict early TNF inhibitor users in patients with ankylosing spondylitis. The baseline demographic and laboratory data of patients who visited Samsung Medical Center rheumatology clinic from Dec. 2003 to Sep. 2018 were analyzed. Patients were divided into two groups: early-TNF and non-early-TNF users. Machine learning models were formulated to predict the early-TNF users using the baseline data. Feature importance analysis was performed to delineate significant baseline characteristics. The numbers of early-TNF and non-early-TNF users were 90 and 505, respectively. The performance of the ANN model, based on the area under curve (AUC) for a receiver operating characteristic curve (ROC) of 0.783, was superior to logistic regression, support vector machine, random forest, and XGBoost models (for an ROC curve of 0.719, 0.699, 0.761, and 0.713, respectively) in predicting early-TNF users. Feature importance analysis revealed CRP and ESR as the top significant baseline characteristics for predicting early-TNF users. Our model displayed superior performance in predicting early-TNF users compared with logistic regression and other machine learning models. Machine learning can be a vital tool in predicting treatment response in various rheumatologic diseases.

scholarly journals Prediction of perinatal death using machine learning models: a birth registry-based cohort study in northern Tanzania

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e040132
Author(s):  
Innocent B Mboya ◽  
Michael J Mahande ◽  
Mohanad Mohammed ◽  
Joseph Obure ◽  
Henry G Mwambi
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Regression Model ◽  
Logistic Regression Model ◽  
Perinatal Death ◽  
Learning Models ◽  
Net Benefit ◽  
Birth Registry ◽  
Perinatal Deaths ◽  
Machine Learning Models

ObjectiveWe aimed to determine the key predictors of perinatal deaths using machine learning models compared with the logistic regression model.DesignA secondary data analysis using the Kilimanjaro Christian Medical Centre (KCMC) Medical Birth Registry cohort from 2000 to 2015. We assessed the discriminative ability of models using the area under the receiver operating characteristics curve (AUC) and the net benefit using decision curve analysis.SettingThe KCMC is a zonal referral hospital located in Moshi Municipality, Kilimanjaro region, Northern Tanzania. The Medical Birth Registry is within the hospital grounds at the Reproductive and Child Health Centre.ParticipantsSingleton deliveries (n=42 319) with complete records from 2000 to 2015.Primary outcome measuresPerinatal death (composite of stillbirths and early neonatal deaths). These outcomes were only captured before mothers were discharged from the hospital.ResultsThe proportion of perinatal deaths was 3.7%. There were no statistically significant differences in the predictive performance of four machine learning models except for bagging, which had a significantly lower performance (AUC 0.76, 95% CI 0.74 to 0.79, p=0.006) compared with the logistic regression model (AUC 0.78, 95% CI 0.76 to 0.81). However, in the decision curve analysis, the machine learning models had a higher net benefit (ie, the correct classification of perinatal deaths considering a trade-off between false-negatives and false-positives)—over the logistic regression model across a range of threshold probability values.ConclusionsIn this cohort, there was no significant difference in the prediction of perinatal deaths between machine learning and logistic regression models, except for bagging. The machine learning models had a higher net benefit, as its predictive ability of perinatal death was considerably superior over the logistic regression model. The machine learning models, as demonstrated by our study, can be used to improve the prediction of perinatal deaths and triage for women at risk.

scholarly journals Predicting failures of Molteno and Baerveldt glaucoma drainage devices using machine learning models

2019 ◽  
Author(s):  
Paul Morrison ◽  
Maxwell Dixon ◽  
Arsham Sheybani ◽  
Bahareh Rahmani
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Intraocular Pressure ◽  
Glaucoma Drainage Device ◽  
Recursive Feature Elimination ◽  
Support Vector ◽  
Learning Models ◽  
Glaucoma Drainage Devices ◽  
Pressure Lowering ◽  
Machine Learning Models

AbstractThe purpose of this retrospective study is to measure machine learning models’ ability to predict glaucoma drainage device failure based on demographic information and preoperative measurements. The medical records of sixty-two patients were used. Potential predictors included the patient’s race, age, sex, preoperative intraocular pressure, preoperative visual acuity, number of intraocular pressure-lowering medications, and number and type of previous ophthalmic surgeries. Failure was defined as final intraocular pressure greater than 18 mm Hg, reduction in intraocular pressure less than 20% from baseline, or need for reoperation unrelated to normal implant maintenance. Five classifiers were compared: logistic regression, artificial neural network, random forest, decision tree, and support vector machine. Recursive feature elimination was used to shrink the number of predictors and grid search was used to choose hyperparameters. To prevent leakage, nested cross-validation was used throughout. Overall, the best classifier was logistic regression.

scholarly journals The Detection of Opioid Misuse and Heroin Use From Paramedic Response Documentation: Machine Learning for Improved Surveillance (Preprint)

2019 ◽  
Author(s):  
José Tomás Prieto ◽  
Kenneth Scott ◽  
Dean McEwen ◽  
Laura J Podewils ◽  
Alia Al-Tayyib ◽  
...  
Keyword(s):  
Machine Learning ◽  
Logistic Regression ◽  
Receiver Operating Curve ◽  
Reference Standard ◽  
Opioid Misuse ◽  
Learning Models ◽  
Heroin Use ◽  
Naloxone Administration ◽  
Improved Performance ◽  
Machine Learning Models

BACKGROUND Timely, precise, and localized surveillance of nonfatal events is needed to improve response and prevention of opioid-related problems in an evolving opioid crisis in the United States. Records of naloxone administration found in prehospital emergency medical services (EMS) data have helped estimate opioid overdose incidence, including nonhospital, field-treated cases. However, as naloxone is often used by EMS personnel in unconsciousness of unknown cause, attributing naloxone administration to opioid misuse and heroin use (OM) may misclassify events. Better methods are needed to identify OM. OBJECTIVE This study aimed to develop and test a natural language processing method that would improve identification of potential OM from paramedic documentation. METHODS First, we searched Denver Health paramedic trip reports from August 2017 to April 2018 for keywords naloxone, heroin, and both combined, and we reviewed narratives of identified reports to determine whether they constituted true cases of OM. Then, we used this human classification as reference standard and trained 4 machine learning models (random forest, k-nearest neighbors, support vector machines, and L1-regularized logistic regression). We selected the algorithm that produced the highest area under the receiver operating curve (AUC) for model assessment. Finally, we compared positive predictive value (PPV) of the highest performing machine learning algorithm with PPV of searches of keywords naloxone, heroin, and combination of both in the binary classification of OM in unseen September 2018 data. RESULTS In total, 54,359 trip reports were filed from August 2017 to April 2018. Approximately 1.09% (594/54,359) indicated naloxone administration. Among trip reports with reviewer agreement regarding OM in the narrative, 57.6% (292/516) were considered to include information revealing OM. Approximately 1.63% (884/54,359) of all trip reports mentioned heroin in the narrative. Among trip reports with reviewer agreement, 95.5% (784/821) were considered to include information revealing OM. Combined results accounted for 2.39% (1298/54,359) of trip reports. Among trip reports with reviewer agreement, 77.79% (907/1166) were considered to include information consistent with OM. The reference standard used to train and test machine learning models included details of 1166 trip reports. L1-regularized logistic regression was the highest performing algorithm (AUC=0.94; 95% CI 0.91-0.97) in identifying OM. Tested on 5983 unseen reports from September 2018, the keyword naloxone inaccurately identified and underestimated probable OM trip report cases (63 cases; PPV=0.68). The keyword heroin yielded more cases with improved performance (129 cases; PPV=0.99). Combined keyword and L1-regularized logistic regression classifier further improved performance (146 cases; PPV=0.99). CONCLUSIONS A machine learning application enhanced the effectiveness of finding OM among documented paramedic field responses. This approach to refining OM surveillance may lead to improved first-responder and public health responses toward prevention of overdoses and other opioid-related problems in US communities.

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