MRI-based nomogram estimates the risk of recurrence of primary nonmetastatic pancreatic neuroendocrine tumors after curative resection

2018 ◽  
Vol 50 (2) ◽  
pp. 397-409 ◽  
Author(s):  
Hai-Tao Sun ◽  
Shi-Long Zhang ◽  
Kai Liu ◽  
Jian-Jun Zhou ◽  
Xing-Xing Wang ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Curative Resection ◽  
Pancreatic Neuroendocrine Tumors ◽  
Risk Of Recurrence

scholarly journals Clinical significance of the preoperative main pancreatic duct dilation and neutrophil-to-lymphocyte ratio in pancreatic neuroendocrine tumors (PNETs) of the head after curative resection

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Bo Zhou ◽  
Canyang Zhan ◽  
Jie Xiang ◽  
Yuan Ding ◽  
Sheng Yan
Keyword(s):  
Pancreatic Duct ◽  
Neuroendocrine Tumors ◽  
Main Pancreatic Duct ◽  
Curative Resection ◽  
Who Classification ◽  
Prognostic Significance ◽  
Small Sample ◽  
Neutrophil To Lymphocyte Ratio ◽  
Pancreatic Neuroendocrine Tumors ◽  
Lymphocyte Ratio

Abstract Background The present study aimed to investigate the prognostic significance of preoperative main pancreatic duct dilation and the neutrophil-to-lymphocyte ratio (PD-NLR) in pancreatic neuroendocrine tumors (PNETs) of the head after curative resection. Methods Sixty-four consecutive PNETs of the head that underwent curative resection were included in the study. Preoperative main pancreatic duct dilation (PD) was defined as a pancreatic duct dilation greater than 3 mm before surgery. Patients with both PD and an elevated NLR (> 3.13), with PD or elevated NLR, or neither of these characteristics were allocated a PD-NLR score of 2, 1, or 0, respectively. Univariate, multivariate and Kaplan-Meier analyses were used to calculate overall survival (OS) and disease-free survival (DFS). Results Preoperative PD-NLR score was correlated with tumor size (P = 0.005), T-stage (P = 0.016), lymph node metastasis (P <  0.001), distant metastasis (P = 0.005), type of hormone production (P = 0.006), perineural invasion (P = 0.014), and WHO classification (P <  0.001). Patients with a high PD-NLR score had a significantly poor OS and DFS relative to those with a low PD-NLR score (P <  0.001). In the multivariate analysis, PD-NLR score was an independent predictor of OS and DFS for PNET of the head (both P <  0.05). In the analyses of the various subgroups, preoperative PD-NLR score was also a predictor of OS and DFS. Additionally, the survival predictive capability of PD-NLR score was superior to that of WHO classification. Conclusions Despite the retrospective nature and small sample size of the present study, the results suggest that preoperative PD-NLR score can serve as an independent prognostic marker of early survival in patients with PNETs of the head undergoing curative resection. Further large prospective studies are necessary to validate our findings.

Nomogram to predict recurrence after curative resection of pancreatic neuroendocrine tumors.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e15654-e15654
Author(s):  
Cansu Guney Genc ◽  
Stefano Partelli ◽  
Massimo Falconi ◽  
Francesca Muffatti ◽  
Susan van Dieren ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Curative Resection ◽  
Pancreatic Neuroendocrine Tumors

scholarly journals The risk of recurrence in Grade 2 pancreatic neuroendocrine tumors

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S584
Author(s):  
O. Guevara ◽  
H. Facundo ◽  
R. Pinilla ◽  
R. Oliveros
Keyword(s):  
Neuroendocrine Tumors ◽  
Pancreatic Neuroendocrine Tumors ◽  
Risk Of Recurrence

Nomogram to predict recurrence after curative resection of pancreatic neuroendocrine tumors

Pancreatology ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. S61
Author(s):  
Cansu Genç ◽  
Stefano Partelli ◽  
Massimo Falconi ◽  
Francesca Muffatti ◽  
Anneke Jilesen ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Curative Resection ◽  
Pancreatic Neuroendocrine Tumors
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