Abnormal Hippocampal Subfields May Be Potential Predictors of Worse Early Response to Antidepressant Treatment in Drug‐Naïve Patients With Major Depressive Disorder

2018 ◽  
Vol 49 (6) ◽  
pp. 1760-1768 ◽  
Author(s):  
Xiaoxiao Hu ◽  
Lianqing Zhang ◽  
Xinyu Hu ◽  
Lu Lu ◽  
Shi Tang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Antidepressant Treatment ◽  
Early Response ◽  
Major Depressive ◽  
Hippocampal Subfields ◽  
Drug Naïve

scholarly journals Structural Changes in Hippocampal Subfields in Patients with Continuous Remission of Drug-Naive Major Depressive Disorder

2020 ◽  
Vol 21 (9) ◽  
pp. 3032 ◽  
Author(s):  
Asuka Katsuki ◽  
Keita Watanabe ◽  
LeHoa Nguyen ◽  
Yuka Otsuka ◽  
Ryohei Igata ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Rating Scale ◽  
Antidepressant Treatment ◽  
Critical Role ◽  
Granule Cell Layer ◽  
Limbic Structure ◽  
Major Depressive ◽  
Hippocampal Subfields ◽  
Drug Naïve

Objective: Hippocampal volume is reduced in patients with major depressive disorder (MDD) compared with healthy controls. The hippocampus is a limbic structure that has a critical role in MDD. The aim of the present study was to investigate the changes in the volume of the hippocampus and its subfields in MDD patients who responded to antidepressants and subsequently were in continuous remission. Subjects and Methods: Eighteen patients who met the following criteria were enrolled in the present study: the DSM-IV-TR criteria for MDD, drug-naïve at least 8 weeks or more, scores on the 17-items of Hamilton Rating Scale for Depression (HAMD) of 14 points or more, and antidepressant treatment response within 8 weeks and continuous remission for at least 6 months. All participants underwent T1-weighted structural MRI and were treated with antidepressants for more than 8 weeks. We compared the volumes of the hippocampus, including its subfields, in responders at baseline to the volumes at 6 months. The volumes of the whole hippocampus and the hippocampal subfields were measured using FreeSurfer v6.0. Results: The volumes of the left cornu Ammonis (CA) 3 (p = 0.016) and the granule cell layer of the dentate gyrus (GC-DG) region (p = 0.021) were significantly increased after 6 months of treatment compared with those at baseline. Conclusions: Increases in volume was observed in MDD patients who were in remission for at least 6 months.

Editorial for “Ensemble Learning for Early‐Response Prediction of Antidepressant Treatment in Major Depressive Disorder”

2020 ◽  
Vol 52 (1) ◽  
pp. 172-173
Author(s):  
Abhinav Srinath ◽  
Sharbel Romanos ◽  
Seán B. Lyne ◽  
Benjamin Leporq ◽  
Janne Koskimäki ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Ensemble Learning ◽  
Antidepressant Treatment ◽  
Response Prediction ◽  
Early Response ◽  
Major Depressive

scholarly journals Hippocampal Subfields in Acute and Remitted Depression—an Ultra-High Field Magnetic Resonance Imaging Study

2019 ◽  
Vol 22 (8) ◽  
pp. 513-522 ◽  
Author(s):  
Christoph Kraus ◽  
Rene Seiger ◽  
Daniela M Pfabigan ◽  
Ronald Sladky ◽  
Martin Tik ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
High Field ◽  
Antidepressant Treatment ◽  
Resonance Imaging ◽  
Volume Changes ◽  
Major Depressive ◽  
Ultra High Field ◽  
Hippocampal Subfields ◽  
The Right

AbstractBackgroundStudies investigating hippocampal volume changes after treatment with serotonergic antidepressants in patients with major depressive disorder yielded inconsistent results, and effects on hippocampal subfields are unclear.MethodsTo detail treatment effects on total hippocampal and subfield volumes, we conducted an open-label study with escitalopram followed by venlafaxine upon nonresponse in 20 unmedicated patients with major depressive disorder. Before and after 12 weeks treatment, we measured total hippocampal formation volumes and subfield volumes with ultra-high field (7 Tesla), T1-weighted, structural magnetic resonance imaging, and FreeSurfer. Twenty-eight remitted patients and 22 healthy subjects were included as controls. We hypothesized to detect increased volumes after treatment in major depressive disorder.ResultsWe did not detect treatment-related changes of total hippocampal or subfield volumes in patients with major depressive disorder. Secondary results indicated that the control group of untreated, stable remitted patients, compared with healthy controls, had larger volumes of the right hippocampal-amygdaloid transition area and right fissure at both measurement time points. Depressed patients exhibited larger volumes of the right subiculum compared with healthy controls at MRI-2. Exploratory data analyses indicated lower baseline volumes in the subgroup of remitting (n = 10) vs nonremitting (n = 10) acute patients.ConclusionsThe results demonstrate that monoaminergic antidepressant treatment in major depressive disorder patients was not associated with volume changes in hippocampal subfields. Studies with larger sample sizes to detect smaller effects as well as other imaging modalities are needed to further assess the impact of antidepressant treatment on hippocampal subfields.

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