Radiomic signature as a predictive factor for lymph node metastasis in early-stage cervical cancer

2018 ◽  
Vol 49 (1) ◽  
pp. 304-310 ◽  
Author(s):  
Yangyang Kan ◽  
Di Dong ◽  
Yuchen Zhang ◽  
Wenyan Jiang ◽  
Nannan Zhao ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Predictive Factor ◽  
Early Stage ◽  
Node Metastasis ◽  
Early Stage Cervical Cancer

scholarly journals microRNA Profile Associated with Positive Lymph Node Metastasis in Early-Stage Cervical Cancer

2022 ◽  
Vol 29 (1) ◽  
pp. 243-254
Author(s):  
Salim Abraham Barquet-Muñoz ◽  
Abraham Pedroza-Torres ◽  
Carlos Perez-Plasencia ◽  
Sarita Montaño ◽  
Lenny Gallardo-Alvarado ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Mirna Expression ◽  
Early Stage ◽  
Positive Lymph Node ◽  
Node Metastasis ◽  
Microrna Profile ◽  
Early Stage Cervical Cancer ◽  
And Cluster Analysis

Lymph node metastasis (LNM) is an important prognostic factor in cervical cancer (CC). In early stages, the risk of LNM is approximately 3.7 to 21.7%, and the 5-year overall survival decreases from 80% to 53% when metastatic disease is identified in the lymph nodes. Few reports have analyzed the relationship between miRNA expression and the presence of LNM. The aim of this study was to identify a subset of miRNAs related to LNM in early-stage CC patients. Formalin-fixed paraffin-embedded tissue blocks were collected from patients with early-stage CC treated by radical hysterectomy with lymphadenectomy. We analyzed samples from two groups of patients—one group with LNM and the other without LNM. Global miRNA expression was identified by microarray analysis, and cluster analysis was used to determine a subset of miRNAs associated with LNM. Microarray expression profiling identified a subset of 36 differentially expressed miRNAs in the two groups (fold change (FC) ≥ 1.5 and p < 0.01). We validated the expression of seven miRNAs; miR-487b, miR-29b-2-5p, and miR-195 were underexpressed, and miR-92b-5p, miR-483-5p, miR-4534, and miR-548ac were overexpressed according to the microarray experiments. This signature exhibited prognostic value for identifying early-stage CC patients with LNM. These findings may help detect LNM that cannot be observed in imaging studies.

Further stratification of risk groups in patients with lymph node metastasis after radical hysterectomy for early-stage cervical cancer

2010 ◽  
Vol 117 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Jeong-Yeol Park ◽  
Dae-Yeon Kim ◽  
Jong-Hyeok Kim ◽  
Yong-Man Kim ◽  
Young-Tak Kim ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Radical Hysterectomy ◽  
Early Stage ◽  
Risk Groups ◽  
Node Metastasis ◽  
Early Stage Cervical Cancer

Lymph Node Metastasis in Patients with Clinical Early-Stage Cervical Cancer: Detection with Integrated FDG PET/CT

Radiology ◽  
2006 ◽  
Vol 238 (1) ◽  
pp. 272-279 ◽  
Author(s):  
Sandro Sironi ◽  
Alessandro Buda ◽  
Maria Picchio ◽  
Patrizia Perego ◽  
Rossella Moreni ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Detection ◽  
Fdg Pet ◽  
Early Stage ◽  
Node Metastasis ◽  
Pet Ct ◽  
Early Stage Cervical Cancer ◽  
Fdg Pet Ct

P67 Gene signature and lymph node metastasis in patients with early stage cervical cancer

2007 ◽  
Vol 5 (8) ◽  
pp. 20
Author(s):  
P. Biewenga ◽  
M. Buist ◽  
P. Moerland ◽  
E. Ver Loren van Themaat ◽  
A. van Kampen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Stage ◽  
Gene Signature ◽  
Node Metastasis ◽  
Early Stage Cervical Cancer
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