MRI-based measurements of whole-brain global cerebral blood flow: Comparison and validation at 1.5T and 3T

2018 ◽  
Vol 48 (5) ◽  
pp. 1273-1280 ◽  
Author(s):  
Chun-Ming Chen ◽  
Yen-Chih Huang ◽  
Cheng-Ting Shih ◽  
Yung-Fang Chen ◽  
Shin-Lei Peng
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Whole Brain ◽  
Global Cerebral Blood Flow

Effect of Ketanserin on Global Cerebral Blood Flow and Middle Cerebral Artery Flow Velocity

1995 ◽  
Vol 80 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Andreas Weyland ◽  
Heidrun Stephan ◽  
Frank Grune ◽  
Wolfgang Weyland ◽  
Hans Sonntag
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Middle Cerebral Artery ◽  
Flow Velocity ◽  
Cerebral Artery ◽  
Global Cerebral Blood Flow ◽  
Artery Flow

scholarly journals Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity

2014 ◽  
Vol 116 (9) ◽  
pp. 1189-1196 ◽  
Author(s):  
Nia C. S. Lewis ◽  
Laura Messinger ◽  
Brad Monteleone ◽  
Philip N. Ainslie
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Sympathetic Nerve ◽  
Regional Difference ◽  
Sympathetic Nerve Activity ◽  
Acute Hypoxia ◽  
Adrenergic Blockade ◽  
Percentage Increase ◽  
Nerve Activity ◽  
Global Cerebral Blood Flow

We examined 1) whether global cerebral blood flow (CBF) would increase across a 6-h bout of normobaric poikilocapnic hypoxia and be mediated by a larger increase in blood flow in the vertebral artery (VA) than in the internal carotid artery (ICA); and 2) whether additional increases in global CBF would be evident following an α1-adrenergic blockade via further dilation of the ICA and VA. In 11 young normotensive individuals, ultrasound measures of ICA and VA flow were obtained in normoxia (baseline) and following 60, 210, and 330 min of hypoxia (FiO2 = 0.11). Ninety minutes prior to final assessment, participants received an α1-adrenoreceptor blocker (prazosin, 1 mg/20 kg body mass) or placebo. Compared with baseline, following 60, 220, and 330 min of hypoxia, global CBF [(ICAFlow + VAFlow) ∗ 2] increased by 160 ± 52 ml/min (+28%; P = 0.05), 134 ± 23 ml/min (+23%; P = 0.02), and 113 ± 51 (+19%; P = 0.27), respectively. Compared with baseline, ICAFlow increased by 23% following 60 min of hypoxia ( P = 0.06), after which it progressively declined. The percentage increase in VA flow was consistently larger than ICA flow during hypoxia by ∼20% ( P = 0.002). Compared with baseline, ICA and VA diameters increased during hypoxia by ∼9% and ∼12%, respectively ( P ≤ 0.05), and were correlated with reductions in SaO2. Flow and diameters were unaltered following α1 blockade ( P ≥ 0.10). In conclusion, elevations in global CBF during acute hypoxia are partly mediated via greater increases in VA flow compared with ICA flow; this regional difference was unaltered following α1 blockade, indicating that a heightened sympathetic nerve activity with hypoxia does not constrain further dilation of larger extracranial blood vessels.

Global cerebral blood flow, blood volume, and oxygen metabolism in patients with migraine headache

Neurology ◽  
1998 ◽  
Vol 50 (6) ◽  
pp. 1736-1740 ◽  
Author(s):  
E. M. Bednarczyk ◽  
B. Remler ◽  
C. Weikart ◽  
A. D. Nelson ◽  
R. C. Reed
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Blood Volume ◽  
Migraine Headache ◽  
Oxygen Metabolism ◽  
Global Cerebral Blood Flow

scholarly journals Phase contrast mapping MRI measurements of global cerebral blood flow across different perfusion states – A direct comparison with 15O-H2O positron emission tomography using a hybrid PET/MR system

2018 ◽  
Vol 39 (12) ◽  
pp. 2368-2378 ◽  
Author(s):  
Oriol Puig ◽  
Mark B Vestergaard ◽  
Ulrich Lindberg ◽  
Adam E Hansen ◽  
Annette Ulrich ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Strong Correlation ◽  
Phase Contrast ◽  
Young Male ◽  
Emission Tomography ◽  
Easy Access ◽  
Positron Emission ◽  
Global Cerebral Blood Flow

Phase-contrast mapping (PCM) magnetic resonance imaging (MRI) provides easy-access non-invasive quantification of global cerebral blood flow (gCBF) but its accuracy in altered perfusion states is not established. We aimed to compare paired PCM MRI and 15O-H2O positron emission tomography (PET) measurements of gCBF in different perfusion states in a single scanning session. Duplicate combined gCBF PCM-MRI and 15O-H2O PET measurements were performed in the resting condition, during hyperventilation and after acetazolamide administration (post-ACZ) using a 3T hybrid PET/MR system. A total of 62 paired gCBF measurements were acquired in 14 healthy young male volunteers. Average gCBF in resting state measured by PCM-MRI and 15O-H2O PET were 58.5 ± 10.7 and 38.6 ± 5.7 mL/100 g/min, respectively, during hyperventilation 33 ± 8.6 and 24.7 ± 5.8 mL/100 g/min, respectively, and post-ACZ 89.6 ± 27.1 and 57.3 ± 9.6 mL/100 g/min, respectively. On average, gCBF measured by PCM-MRI was 49% higher compared to 15O-H2O PET. A strong correlation between the two methods across all states was observed (R2 = 0.72, p < 0.001). Bland–Altman analysis suggested a perfusion dependent relative bias resulting in higher relative difference at higher CBF values. In conclusion, measurements of gCBF by PCM-MRI in healthy volunteers show a strong correlation with 15O-H2O PET, but are associated with a large and non-linear perfusion-dependent difference.

scholarly journals Acute effects of cigarette smoking on global cerebral blood flow (GCBF) in overnight abstinent tobacco smokers

2005 ◽  
Vol 77 (2) ◽  
pp. P67-P67
Author(s):  
T SHINOHARA ◽  
K NAGATA ◽  
E YOKOYAMA ◽  
M SATO ◽  
S MATSUOKA ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cigarette Smoking ◽  
Acute Effects ◽  
Global Cerebral Blood Flow

scholarly journals Automatic and Reproducible Positioning of Phase-Contrast MRI for the Quantification of Global Cerebral Blood Flow

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e95721 ◽  
Author(s):  
Peiying Liu ◽  
Hanzhang Lu ◽  
Francesca M. Filbey ◽  
Amy E. Pinkham ◽  
Carrie J. McAdams ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Phase Contrast ◽  
Phase Contrast Mri ◽  
Global Cerebral Blood Flow
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