Intravoxel incoherent motion MRI in the brain: Impact of the fitting model on perfusion fraction and lesion differentiability

2017 ◽  
Vol 46 (4) ◽  
pp. 1187-1199 ◽  
Author(s):  
Vera C. Keil ◽  
Burkhard Mädler ◽  
Gerrit H. Gielen ◽  
Bogdan Pintea ◽  
Kanishka Hiththetiya ◽  
...  
Keyword(s):  
Intravoxel Incoherent Motion ◽  
Perfusion Fraction ◽  
Motion Mri ◽  
The Brain ◽  
Fitting Model

Intravoxel incoherent motion magnetic resonance imaging for assessment of chronic pancreatitis with special focus on its early stage

2019 ◽  
Vol 61 (5) ◽  
pp. 579-585 ◽  
Author(s):  
Nobuhiro Fujita ◽  
Akihiro Nishie ◽  
Yoshiki Asayama ◽  
Kousei Ishigami ◽  
Nao Fujimori ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diffusion Coefficient ◽  
Chronic Pancreatitis ◽  
Magnetic Resonance ◽  
Intravoxel Incoherent Motion ◽  
Control Group ◽  
Imaging Method ◽  
Resonance Imaging ◽  
Perfusion Fraction ◽  
Motion Mri

Background It is clinically necessary to validate a new non-invasive and reliable imaging method to detect early chronic pancreatitis. Intravoxel incoherent motion magnetic resonance imaging (MRI) is useful for quantitative assessment in abdominal solid organs. Purpose To investigate the usefulness of intravoxel incoherent motion MRI parameters in the diagnosis of chronic pancreatitis. Material and Methods Sixty patients with early chronic pancreatitis (n = 44) and chronic pancreatitis (n = 16) were assessed with intravoxel incoherent motion imaging. For comparison, a control group of 71 individuals without chronic pancreatitis was also enrolled. The perfusion fraction (f), pseudo-diffusion coefficient (D*), true diffusion coefficient (D), and apparent diffusion coefficient of pancreatic parenchyma were calculated. These measurements were compared between the three groups. The diagnostic accuracy of imaging parameters was assessed. Results The f values of the early chronic pancreatitis group and the chronic pancreatitis group were significantly lower than those of the control group ( P < 0.001 and P < 0.001, respectively). The D* value of the chronic pancreatitis group was significantly lower than that of the early chronic pancreatitis group ( P = 0.0025). The D values of the early chronic pancreatitis group and the chronic pancreatitis group were significantly higher than those of the control group ( P = 0.001 and P = 0.001, respectively). The perfusion fraction showed the highest diagnostic performance with an Az value of 0.76 for discriminating the control group from the early chronic pancreatitis and chronic pancreatitis groups. Conclusion Intravoxel incoherent motion MRI parameters may reflect the minimal histological changes in early chronic pancreatitis.

Distribution of intravoxel incoherent motion MRI-related parameters in the brain: evidence of interhemispheric asymmetry

2017 ◽  
Vol 72 (1) ◽  
pp. 94.e1-94.e6 ◽  
Author(s):  
C. Wang ◽  
D. Ren ◽  
Y. Guo ◽  
Y. Xu ◽  
Y. Feng ◽  
...  
Keyword(s):  
Intravoxel Incoherent Motion ◽  
Interhemispheric Asymmetry ◽  
Motion Mri ◽  
The Brain

Development of imaging biomarker for esophageal cancer using intravoxel incoherent motion MRI

Esophagus ◽  
2021 ◽  
Author(s):  
Ryoya Mizumachi ◽  
Koichi Hayano ◽  
Atsushi Hirata ◽  
Gaku Ohira ◽  
Shunsuke Imanishi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Intravoxel Incoherent Motion ◽  
Imaging Biomarker ◽  
Motion Mri

scholarly journals Intravoxel incoherent motion MRI for the initial characterization of non-fatty non-vascular soft tissue tumors

2020 ◽  
Vol 101 (4) ◽  
pp. 245-255 ◽  
Author(s):  
P.A. Gondim Teixeira ◽  
L. Simon ◽  
F. Sirveaux ◽  
B. Marie ◽  
M. Louis ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumors ◽  
Intravoxel Incoherent Motion ◽  
Initial Characterization ◽  
Motion Mri

scholarly journals Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease

2020 ◽  
Vol 51 (4) ◽  
Author(s):  
Sau May Wong ◽  
Walter H. Backes ◽  
Gerhard S. Drenthen ◽  
C. Eleana Zhang ◽  
Paulien H.M. Voorter ◽  
...  
Keyword(s):  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Spectral Diffusion ◽  
Small Vessel ◽  
Intravoxel Incoherent Motion ◽  
Vessel Disease ◽  
Diffusion Analysis ◽  
Motion Mri

Triggered intravoxel incoherent motion MRI for the assessment of calf muscle perfusion during isometric intermittent exercise

2018 ◽  
Vol 31 (6) ◽  
pp. e3922 ◽  
Author(s):  
Alfonso Mastropietro ◽  
Simone Porcelli ◽  
Marcello Cadioli ◽  
Letizia Rasica ◽  
Elisa Scalco ◽  
...  
Keyword(s):  
Intermittent Exercise ◽  
Calf Muscle ◽  
Intravoxel Incoherent Motion ◽  
Muscle Perfusion ◽  
Motion Mri

Enhancing intravoxel incoherent motion parameter mapping in the brain using k -b PCA

2018 ◽  
Vol 31 (12) ◽  
pp. e4008 ◽  
Author(s):  
Georg R. Spinner ◽  
Johannes F.M. Schmidt ◽  
Constantin von Deuster ◽  
Christian Federau ◽  
Christian T. Stoeck ◽  
...  
Keyword(s):  
Motion Parameter ◽  
Intravoxel Incoherent Motion ◽  
Parameter Mapping ◽  
The Brain

Value of intravoxel incoherent motion for differential diagnosis of renal tumors

2018 ◽  
Vol 60 (3) ◽  
pp. 382-387 ◽  
Author(s):  
Qingqiang Zhu ◽  
Wenrong Zhu ◽  
Jing Ye ◽  
Jingtao Wu ◽  
Wenxin Chen ◽  
...  
Keyword(s):  
Renal Cell ◽  
Clear Cell ◽  
Threshold Value ◽  
Intravoxel Incoherent Motion ◽  
Renal Tumors ◽  
Threshold Values ◽  
Renal Cell Carcinomas ◽  
Perfusion Fraction ◽  
D Values ◽  
Tumor Types

Background Few studies have reported on the use of intravoxel incoherent motion (IVIM) for renal tumors. Purpose To investigate the value of IVIM for distinguishing renal tumors. Material and Methods Thirty-one patients with clear cell renal cell carcinomas (CCRCCs), 13 patients with renal angiomyolipomas with minimal fat (RAMFs), eight patients with chromophobe renal cell carcinomas (ChRCCs), and ten patients with papillary renal cell carcinomas (PRCCs) were examined. The tissue diffusivity (D), pseudodiffusivity (D*), and perfusion fraction (f) were calculated. Results The D and f values were highest for CCRCCs, lowest for PRCCs, and intermediate for ChRCCs and RAMFs ( P < 0.05). The D values of CCRCCs differed significantly from those of ChRCCs and PRCCs ( P < 0.05). The D* values were highest for RAMFs, lowest for ChRCCs, and intermediate for CCRCCs and PRCCs ( P < 0.05). Statistically significant differences were observed between the D* values of CCRCCs and RAMFs ( P < 0.05). The D* values of the CCRCCs differed significantly from the D* values of the ChRCCs ( P < 0.05). Using the D and f values of 1.10 and 0.41, respectively, as the threshold values for differentiating CCRCCs from RAMFs, ChRCCs, and PRCCs, the best results had sensitivities of 81.0% and 66.8% and specificities of 85.7% and 81.0%, respectively. Using the D* value of 0.038 as the threshold value for differentiating RAMFs from CCRCCs, ChRCCs, and PRCCs, the best result obtained had a sensitivity of 90.5% and specificity of 76.2%. Conclusion IVIM may provide information for differentiating renal tumor types.

Intravoxel incoherent motion diffusion-weighted imaging assessment of microvascular characteristics in the murine embryonal rhabdomyosarcoma model

2019 ◽  
Vol 61 (2) ◽  
pp. 260-266
Author(s):  
Yuan Yuan ◽  
Dewei Zeng ◽  
Yu Zhang ◽  
Juan Tao ◽  
Yajie Liu ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Microvessel Density ◽  
Diffusion Weighted Imaging ◽  
Embryonal Rhabdomyosarcoma ◽  
Intravoxel Incoherent Motion ◽  
Microvascular Blood Flow ◽  
Vegf Expression ◽  
Perfusion Fraction ◽  
Diffusion Weighted ◽  
D Value

Background Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) can distinguish the false diffusion generated by microvascular blood flow from the true water molecule diffusion. Purpose To investigate the correlation between IVIM-DWI parameters and angiogenic markers such as the microvessel density and vascular endothelial growth factor (VEGF) expression in the murine embryonal rhabdomyosarcoma model. Material and Methods The murine embryonal rhabdomyosarcoma model was produced by subcutaneously injecting 107 human embryonal rhabdomyosarcoma cells into the right back of nude mice. The apparent diffusion coefficient (ADC), pseudo-diffusion coefficient (D*), true diffusion coefficient (D), and perfusion fraction (f) were obtained from 22 mice models using IVIM-DWI with b-values of 0, 50, 100, 150, 200, 400, 600, 800, 1000, and 1200 s/mm2. The microvessel density and VEGF expression were obtained by histologic examination. We then compared the correlation between IVIM-DWI parameters and microvessel density and VEGF expression. Results The average ADC, D*, D, and f values were 1.05 ± 0.27 × 10−3 mm2/s, 6.19 ± 1.78 × 10−3 mm2/s, 0.69 ± 0.09 ×10−3 mm2/s, and 17.68 ± 8.41 (%), respectively. There was moderate positive correlation between D* value and microvessel density and VEGF expression (r = 0.484, P = 0.023; r = 0.511, P = 0.015). However, there was no significant correlation between ADC, D, and f values and microvessel density and VEGF expression. Conclusion The D* value from IVIM-DWI may be used to evaluate tumor angiogenesis in the murine embryonal rhabdomyosarcoma model.

scholarly journals Can introvoxel incoherent motion MRI be used to differentiate patients with placenta accreta spectrum disorders?

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tao Lu ◽  
Hong Pu ◽  
Kui-de Li ◽  
Jie Mei ◽  
Meng-wei Huang ◽  
...  
Keyword(s):  
Placenta Accreta ◽  
Placenta Previa ◽  
Multiple Comparisons ◽  
Placental Perfusion ◽  
Perfusion Fraction ◽  
Motion Mri ◽  
Placenta Accreta Spectrum ◽  
Spectrum Disorders ◽  
Study Participants ◽  
And Diffusion

Abstract Background The incidence of PAS disorders increased rapidly in recent years, and introvoxel incoherent motion (IVIM) MRI has been applied in the assessment of placenta. The study aims to investigate whether the parameters from IVIM can be used to differentiate patients with PAS disorders complicating placenta previa and secondly to differentiate different categories of PAS disorders. Methods The study participants were comprised of 99 patients with placenta previa, including 16 patients with placenta accreta, 51 patients with increta, 8 patients with percreta and 24 patients without PAS disorders between 28 + 0 and 39 + 6 weeks. IVIM MRI was performed on a 1.5 T scanner. Perfusion fraction (f), pseudodiffusion coefficient (D*) and diffusion coefficient (D) were calculated. Results Women with PAS disorders had a higher perfusion fraction (p = 0.019) than women without the disease. Multiple comparisons showed perfusion fraction in patients without PAS disorders was significantly lower than in patients with placenta accreta and percreta(P = 0.018 and 0.033 respectively), but was not lower than in patients with increta(p = 1). Conclusion Patients with placenta accreta and percreta differed in placental perfusion fraction from women with increta and without PAS disorders.

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