Cerebral blood flow laterality derived from arterial spin labeling as a biomarker for assessing the disease severity of parkinson's disease

2016 ◽  
Vol 45 (6) ◽  
pp. 1821-1826 ◽  
Author(s):  
Koji Yamashita ◽  
Akio Hiwatashi ◽  
Osamu Togao ◽  
Kazufumi Kikuchi ◽  
Hiroo Yamaguchi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Disease Severity ◽  
Arterial Spin Labeling ◽  
Spin Labeling

scholarly journals Effects of acute levodopa challenge on resting cerebral blood flow in Parkinson’s Disease patients assessed using pseudo-continuous arterial spin labeling

PeerJ ◽  
2015 ◽  
Vol 3 ◽  
pp. e1381 ◽  
Author(s):  
Yufen Chen ◽  
Peter Pressman ◽  
Tanya Simuni ◽  
Todd B. Parrish ◽  
Darren R. Gitelman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Clinical Severity ◽  
Precentral Gyrus ◽  
Drug Induced ◽  
Continuous Arterial Spin Labeling

Introduction.Levodopa is the gold-standard for treatment of Parkinson’s disease (PD) related motor symptoms. In this study, we used pseudo-continuous arterial spin labeling (pCASL) to quantify changes in cerebral blood flow (CBF) after acute oral administration of levodopa in PD patients.Materials and Methods.Thirteen patients (3 females, age 66.2 ± 8.7 years) with moderately advanced PD (Hoehn and Yahr stage >2 (median 2.5), disease duration >3 years) were scanned on a 3T Siemens MR scanner before and after oral levodopa administration. Statistical parametric mapping was used to detect drug-induced changes in CBF and its correlation to clinical severity scales. Images were normalized and flipped in order to examine effects on the more affected (left) and less affected (right) cerebral hemispheres across the cohort.Results.Levodopa did not change global CBF but increased regional CBF in dorsal midbrain, precuneus/cuneus, more affected inferior frontal pars opercularis and triangularis, bilateral pre- and postcentral gyri, more affected inferior parietal areas, as well as less affected putamen/globus pallidus by 27–74% (p< 0.05, FWE corrected for multiple comparisons). CBF change was negatively correlated with improvement in bradykinesia UPDRS-III subscore in the more affected precentral gyrus, and total predrug UPDRS-III score in the mid-cingulate region. Drug-induced CBF change in a widespread network of regions including parietal and postcentral areas was also negatively correlated with the predrug rigidity UPDRS-III subscore.Conclusion.These findings are in line with prior reports of abnormal activity in the nigrostriatal pathway of PD patients and demonstrate the feasibility of pCASL as a neuroimaging tool for investigatingin vivophysiological effects of acute drug administration in PD.

Cerebral Blood Flow Measured with 3D Pseudocontinuous Arterial Spin-labeling MR Imaging in Alzheimer Disease and Mild Cognitive Impairment: A Marker for Disease Severity

Radiology ◽  
2013 ◽  
Vol 267 (1) ◽  
pp. 221-230 ◽  
Author(s):  
Maja A. A. Binnewijzend ◽  
Joost P. A. Kuijer ◽  
Marije R. Benedictus ◽  
Wiesje M. van der Flier ◽  
Alle Meije Wink ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer Disease ◽  
Mr Imaging ◽  
Disease Severity ◽  
Arterial Spin Labeling ◽  
Spin Labeling

scholarly journals N-acetyl cysteine administration affects cerebral blood flow as measured by Arterial Spin Labeling MRI in patients with multiple sclerosis

Heliyon ◽  
2021 ◽  
pp. e07615
Author(s):  
Shiva Shahrampour ◽  
Justin Heholt ◽  
Andrew Wang ◽  
Faezeh Vedaei ◽  
Feroze B. Mohamed ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Acetyl Cysteine
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