Diffusion-weighted MRI of pulmonary lesions: Comparison of apparent diffusion coefficient and lesion-to-spinal cord signal intensity ratio in lesion characterization

2016 ◽  
Vol 45 (3) ◽  
pp. 845-854 ◽  
Author(s):  
Vefa Çakmak ◽  
Furkan Ufuk ◽  
Nevzat Karabulut
Keyword(s):  
Spinal Cord ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Signal Intensity ◽  
Intensity Ratio ◽  
Signal Intensity Ratio ◽  
Diffusion Weighted Mri ◽  
Pulmonary Lesions ◽  
Diffusion Weighted ◽  
Apparent Diffusion

scholarly journals Apparent Diffusion Coefficient Signal Intensity Ratio Predicts the Effect of Revascularization on Ischemic Cerebral Edema

2018 ◽  
Vol 45 (3-4) ◽  
pp. 93-100 ◽  
Author(s):  
Matthew B. Bevers ◽  
Thomas W.K. Battey ◽  
Ann-Christin Ostwaldt ◽  
Reza Jahan ◽  
Jeffrey L. Saver ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Cerebral Edema ◽  
Signal Intensity ◽  
Intensity Ratio ◽  
Response To Therapy ◽  
Signal Intensity Ratio ◽  
Edema Formation ◽  
Post Stroke ◽  
Apparent Diffusion

Background: Apparent diffusion coefficient (ADC) imaging is a biomarker of cytotoxic injury that predicts edema formation and outcome after ischemic stroke. It therefore has the potential to serve as a “tissue clock” to describe the extent of ischemic injury and potentially predict response to therapy. The goal of this study was to determine the relationship between baseline ADC signal intensity, revascularization, and edema formation. Methods: We examined the ADC signal intensity ratio (ADCr) of the stroke lesion (defined as the baseline DWI hyperintense region) compared to the contralateral normal hemisphere in 65 subjects from the Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy trial. The associations between ADCr, neurologic outcome, and cerebral edema were examined. Finally, we explored the interaction between baseline ADCr and vessel recanalization at day 7 on post-stroke edema. Results: We found that lower initial ADCr was associated with a worse outcome on the modified Rankin Scale (mRS) at 90 days (52.2% of those with ADCr <64% were mRS 5–6 vs. 19.1% with ADCr ≥64%, p = 0.006). Those subjects with reconstitution of flow distal to the initial vessel occlusion showed greater normalization of ADCr on follow-up scan (increase in ADCr of 16.4 ± 2.07 vs. 1.99 ± 4.33%, p = 0.0039). In those patients with low baseline ADCr, successful revascularization was associated with reduced edema (median swelling volume 164 mL [interquartile range (IQR) 53.3–190 mL] vs. 20.7 mL [IQR 3.20–55.1 mL], p = 0.024). Conclusions: This study reaffirms the association of ADCr with outcome after stroke, supports the idea that reperfusion may attenuate rather than enhance post-stroke edema, and indicates that the degree of edema with and without revascularization may be predicted by ADCr.

Geometric distortion correction in prostate diffusion‐weighted MRI and its effect on quantitative apparent diffusion coefficient analysis

2017 ◽  
Vol 79 (5) ◽  
pp. 2524-2532 ◽  
Author(s):  
Gabriel Nketiah ◽  
Kirsten M Selnæs ◽  
Elise Sandsmark ◽  
Jose R. Teruel ◽  
Brage Krüger‐Stokke ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Distortion Correction ◽  
Geometric Distortion ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted ◽  
Apparent Diffusion
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