scholarly journals Effects of arterial transit delay on cerebral blood flow quantification using arterial spin labeling in an elderly cohort

2016 ◽  
Vol 45 (2) ◽  
pp. 472-481 ◽  
Author(s):  
Weiying Dai ◽  
Tamara Fong ◽  
Richard N. Jones ◽  
Edward Marcantonio ◽  
Eva Schmitt ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Flow Quantification ◽  
Blood Flow Quantification ◽  
Elderly Cohort ◽  
Transit Delay

scholarly journals Cerebral blood flow quantification in the rat: a direct comparison of arterial spin labeling MRI with radioactive microsphere PET

2012 ◽  
Vol 2 (1) ◽  
pp. 47 ◽  
Author(s):  
Agnieszka Boś ◽  
Ralf Bergmann ◽  
Klaus Strobel ◽  
Frank Hofheinz ◽  
Jörg Steinbach ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Flow Quantification ◽  
Blood Flow Quantification ◽  
Radioactive Microsphere

scholarly journals Cerebral blood flow quantification in swine using pseudo-continuous arterial spin labeling

2013 ◽  
Vol 38 (5) ◽  
pp. 1111-1118 ◽  
Author(s):  
Megan E. Johnston ◽  
Zhenlin Zheng ◽  
Joseph A. Maldjian ◽  
Christopher T. Whitlow ◽  
Michael J. Morykwas ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Flow Quantification ◽  
Blood Flow Quantification ◽  
Continuous Arterial Spin Labeling

scholarly journals Cerebral Blood Flow Quantification Using Vessel-Encoded Arterial Spin Labeling

2013 ◽  
Vol 33 (11) ◽  
pp. 1716-1724 ◽  
Author(s):  
Thomas W Okell ◽  
Michael A Chappell ◽  
Michael E Kelly ◽  
Peter Jezzard
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Flow Quantification ◽  
Systematic Bias ◽  
Collateral Flow ◽  
Motion Sensitivity ◽  
Scan Time ◽  
Selective Information

Arterial spin labeling (ASL) techniques are gaining popularity for visualizing and quantifying cerebral blood flow (CBF) in a range of patient groups. However, most ASL methods lack vessel-selective information, which is important for the assessment of collateral flow and the arterial supply to lesions. In this study, we explored the use of vessel-encoded pseudocontinuous ASL (VEPCASL) with multiple postlabeling delays to obtain individual quantitative CBF and bolus arrival time maps for each of the four main brain-feeding arteries and compared the results against those obtained with conventional pseudocontinuous ASL (PCASL) using matched scan time. Simulations showed that PCASL systematically underestimated CBF by up to 37% in voxels supplied by two arteries, whereas VEPCASL maintained CBF accuracy since each vascular component is treated separately. Experimental results in healthy volunteers showed that there is no systematic bias in the CBF estimates produced by VEPCASL and that the signal-to-noise ratio of the two techniques is comparable. Although more complex acquisition and image processing is required and the potential for motion sensitivity is increased, VEPCASL provides comparable data to PCASL but with the added benefit of vessel-selective information. This could lead to more accurate CBF estimates in patients with a significant collateral flow.

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