scholarly journals Reproducibility of myocardial T1 and T2 relaxation time measurement using slice-interleaved T1 and T2 mapping sequences

2016 ◽  
Vol 44 (5) ◽  
pp. 1159-1167 ◽  
Author(s):  
Steven Bellm ◽  
Tamer A. Basha ◽  
Ravi V. Shah ◽  
Venkatesh L. Murthy ◽  
Charlene Liew ◽  
...  
Keyword(s):  
Relaxation Time ◽  
T2 Mapping ◽  
Time Measurement ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
Relaxation Time Measurement ◽  
Myocardial T1 ◽  
T1 And T2

Apparent Diffusion Coefficient, Fractional Anisotropy and T2 Relaxation Time Measurement

2007 ◽  
Vol 17 (4) ◽  
pp. 230-238 ◽  
Author(s):  
Xiao-Qi Ding ◽  
Jürgen Finsterbusch ◽  
Oliver Wittkugel ◽  
Christian Saager ◽  
Einar Goebell ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Relaxation Time ◽  
Apparent Diffusion Coefficient ◽  
Fractional Anisotropy ◽  
Time Measurement ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
Relaxation Time Measurement ◽  
Apparent Diffusion

scholarly journals T1 and T2∗ relaxation time in the parcellated myocardium of healthy Taiwanese participants: A single center study

2020 ◽  
Author(s):  
Chih-Chien Tsai ◽  
Shu-Hang Ng ◽  
Yao-Liang Chen ◽  
Yu-Hsiang Juan ◽  
Chao-Hung Wang ◽  
...  
Keyword(s):  
Relaxation Time ◽  
T2 Relaxation Time ◽  
Single Center ◽  
T2 Relaxation ◽  
Single Center Study ◽  
T1 And T2 ◽  
Center Study

scholarly journals The Effect of Intraventricular Hemorrhage on Brain Development in Premature Infants: A Synthetic MRI Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Chunxiang Zhang ◽  
Xin Zhao ◽  
Meiying Cheng ◽  
Kaiyu Wang ◽  
Xiaoan Zhang
Keyword(s):  
Relaxation Time ◽  
Premature Infants ◽  
Intraventricular Hemorrhage ◽  
Brain Volume ◽  
Relaxation Times ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
T1 And T2 ◽  
The Brain ◽  
Synthetic Mri

Objectives: Synthetic MRI can obtain multiple parameters in one scan, including T1 and T2 relaxation time, proton density (PD), brain volume, etc. This study aimed to investigate the parameter values T1 and T2 relaxation time, PD, and volume characteristics of intraventricular hemorrhage (IVH) newborn brain, and the ability of synthetic MRI parameters T1 and T2 relaxation time and PD to diagnose IVH.Materials and methods: The study included 50 premature babies scanned with conventional and synthetic MRI. Premature infants were allocated to the case group (n = 15) and NON IVH (n = 35). The T1, T2, PD values, and brain volume were obtained by synthetic MRI. Then we assessed the impact of IVH on these parameters.Results: In the posterior limbs of the internal capsule (PLIC), genu of the corpus callosum (GCC), central white matter (CWM), frontal white matter (FWM), and cerebellum (each p < 0.05), the T1 and T2 relaxation times of the IVH group were significantly prolonged. There were significant differences also in PD. The brain volume in many parts were also significantly reduced, which was best illustrated in gray matter (GM), cerebrospinal fluid and intracranial volume, and brain parenchymal fraction (BPF) (each p < 0.001, t = −5.232 to 4.596). The differential diagnosis ability of these quantitative values was found to be excellent in PLIC, CWM, and cerebellum (AUC 0.700–0.837, p < 0.05).Conclusion: The quantitative parameters of synthetic MRI show well the brain tissue characteristic values and brain volume changes of IVH premature infants. T1 and T2 relaxation times and PD contribute to the diagnosis and evaluation of IVH.

scholarly journals Feasibility of T2 Mapping and Magnetic Transfer Ratio for Diagnosis of Intervertebral Disc Degeneration at the Cervicothoracic Junction: A Pilot Study

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Chao Zhang ◽  
Yuan Lin ◽  
Zhihua Han ◽  
Liang Gao ◽  
Ruipeng Guo ◽  
...  
Keyword(s):  
Relaxation Time ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
T2 Mapping ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
Cervicothoracic Junction ◽  
Magnetic Transfer ◽  
Pfirrmann Grade

Background. Intervertebral disc degeneration (IDD) at the cervicothoracic junction of spine is clinically relevant, however, little attention had been paid. T2 mapping and magnetic transfer ratio (MTR) are useful magnetic resonance imaging (MRI) techniques to quantitatively evaluate IDD, revealing the biochemical changes within the intervertebral disc. To compare T2 mapping with MTR imaging regarding their accuracy to quantitatively diagnose intervertebral disc degeneration at the cervicothoracic junction, influences of anatomical level, gender, age, and Pfirrmann grade of T2 relaxation time values and MTR values were evaluated. Methods. Sixty-seven patients with neck and upper back pain were included and examined with both T2 mapping and MTR imaging. The Pfirrmann grade, T2 relaxation time values, and MTR value of each disc between C7 and T3 were measured. Differences were investigated among different segmental levels, genders, age ranges, and Pfirrmann grades. The diagnostic accuracy of both MRI techniques was compared using the receiver operating characteristic (ROC) curves. Results. No significant difference was detected comparing T2 relaxation time values or MTR values among different anatomical levels, genders, and segmental levels. And we generally found that T2 relaxation time values decreased, while MTR value increased with increasing age. Importantly, we demonstrated the significant correlation between either T2 relaxation time values or MTR value and Pfirrmann grade. Conclusion. We proved the better accuracy of T2 mapping over MTR imaging to quantitatively evaluate the intervertebral disc degeneration of the cervicothoracic junction.

scholarly journals Analysis of graft maturation after autologous chondrocyte implantation with T2 mapping

2017 ◽  
Vol 5 (4_suppl4) ◽  
pp. 2325967117S0015
Author(s):  
Thomas R. Niethammer ◽  
Ansgar Loitzsch ◽  
Matthias F. Pietschmann ◽  
Peter E. Müller ◽  
Annie Horng
Keyword(s):  
Relaxation Time ◽  
Autologous Chondrocyte Implantation ◽  
T2 Mapping ◽  
Cartilage Defects ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
Postoperative Course ◽  
Defect Localization ◽  
Chondrocyte Implantation ◽  
Autologous Chondrocyte

Aims and Objectives: It has been shown in numerous clinical studies that matrix-based autologous chondrocyte implantation (mb-ACI) leads to good clinical results in the medium-term course. But chondrogenic development of ACI grafts and the time of graft maturation are still unclear. The aim of this study was to investigate the graft maturation after mb-ACI with T2 mapping in the postoperative course of four years. Materials and Methods: In a total of 90 patients could be included after matrix-based autologous chondrocyte transplantation of the knee. All cartilage defects were treated with NOVOCART® 3D. The evaluation of the ACI grafts was conducted after 3, 6, 12, 24, 36 and 48 months by MRI. The T2 relaxation time values of the ACI graft and healthy native cartilage areas were determined to assess graft maturation using T2 mapping. MOCART score were used for morphological evaluation of ACI grafts. Results: The T2 relaxation time of ACI grafts showed a significant improvement during the postoperative course at all time points. The T2 relaxation improved from 48.0 ms after 3 months to 34.6 ms after four years. We found a significant influence of the patient’s age and the defect localization on the T2 relaxation time measuring. It could be detected an increasing integration of the ACI grafts into the healthy surrounding cartilage. No significant differences between the T2 relaxation time of ACI grafts and the surrounding healthy cartilage were found after 12 months postoperatively. Conclusion: Graft maturation after ACI in the knee joint needs at least 1 year, with ongoing adjustment of the T2 relaxation time values compared with native surrounding cartilage. Regarding the age and defect localization, significantly worse T2 relaxation times of the ACI grafts could be found with higher age and in cases with treated patellar defects.

scholarly journals A Longitudinal Study of T2 Mapping Combined With Diffusion Tensor Imaging to Quantitatively Evaluate Tissue Repair of Rat Skeletal Muscle After Frostbite

2021 ◽  
Vol 11 ◽  
Author(s):  
Yue Gao ◽  
Zhao Lu ◽  
Xiaohong Lyu ◽  
Qiang Liu ◽  
Shinong Pan
Keyword(s):  
Skeletal Muscle ◽  
Relaxation Time ◽  
Diffusion Tensor Imaging ◽  
Muscle Injury ◽  
Diffusion Tensor ◽  
T2 Mapping ◽  
Imaging Biomarkers ◽  
T2 Relaxation Time ◽  
T2 Relaxation ◽  
Skeletal Muscle Injury

Purpose: T2 mapping and diffusion tensor imaging (DTI) enable the detection of changes in the skeletal muscle microenvironment. We assessed T2 relaxation times, DTI metrics, performed histological characterization of frostbite-induced skeletal muscle injury and repair, and provided diagnostic imaging biomarkers.Design and Methods: Thirty-six Sprague Dawley rats (200 ± 10 g) were obtained. Thirty rats were used for establishing a skeletal muscle frostbite model, and six were untreated controls. Functional MR sequences were performed on rats on days 0, 3, 5, 10, and 14 (n = 6 per time point). Rats were then sacrificed to obtain the quadriceps muscles. Tensor eigenvalues (λ1, λ2, and λ3), mean diffusivity (MD), fractional anisotropy (FA), and T2 values were compared between the frostbite model and control rats. ImageJ was used to measure the extracellular area fraction (EAF), muscle fiber cross-sectional area (fCSA), and skeletal muscle tumor necrosis factor α (TNF-α), and Myod1 expression. The correlation between the histological and imaging parameters of the frostbitten skeletal muscle was evaluated. Kolmogorov–Smirnoff test, Leven’s test, one-way ANOVA, and Spearman coefficient were used for analysis.Results: T2 relaxation time of frostbitten skeletal muscle was higher at all time points (p < 0.01). T2 relaxation time correlated with EAF, and TNF-α and Myod1 expression (r = 0.42, p < 0.05; r = 0.86, p < 0.01; r = 0.84, p < 0.01). The average tensor metrics (MD, λ1, λ2, and λ3) of skeletal muscle at 3 and 5 days of frostbite increased (p < 0.05), and fCSA correlated with λ1, λ2, and λ3, and MD (r = 0.65, p < 0.01; r = 0.48, p < 0.01; r = 0.52, p < 0.01; r = 0.62, p < 0.01).Conclusion: T2 mapping and DTI imaging detect frostbite-induced skeletal muscle injury early. This combined approach can quantitatively assess skeletal muscle repair and regeneration within 2 weeks of frostbite. Imaging biomarkers for the diagnosis of frostbite were suggested.

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