How reader perception of capsule affects interpretation of washout in hypervascular liver nodules in patients at risk for hepatocellular carcinoma

2015 ◽  
Vol 43 (6) ◽  
pp. 1337-1345 ◽  
Author(s):  
Keitaro Sofue ◽  
Claude B. Sirlin ◽  
Brian C. Allen ◽  
Rendon C. Nelson ◽  
Carl L. Berg ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
At Risk ◽  
Liver Nodules ◽  
Patients At Risk ◽  
Reader Perception

scholarly journals Diagnostic Accuracy of CEUS LI-RADS for the Characterization of Liver Nodules 20 mm or Smaller in Patients at Risk for Hepatocellular Carcinoma

Radiology ◽  
2020 ◽  
Vol 294 (2) ◽  
pp. 329-339 ◽  
Author(s):  
Jia-Yan Huang ◽  
Jia-Wu Li ◽  
Qiang Lu ◽  
Yan Luo ◽  
Ling Lin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
At Risk ◽  
Diagnostic Accuracy ◽  
Liver Nodules ◽  
Patients At Risk

scholarly journals Diagnostic Accuracy of Contrast-enhanced Ultrasonography Liver Imaging Reporting and Data System in Hepatocellular Carcinoma: A Systematic Review

2021 ◽  
Author(s):  
HuiFang Li ◽  
Wei Huang ◽  
Wei Zheng ◽  
Qing Li ◽  
YunZhu Dai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
At Risk ◽  
Sensitivity And Specificity ◽  
Web Of Science ◽  
Reporting System ◽  
Data System ◽  
Liver Imaging ◽  
Contrast Enhanced ◽  
Patients At Risk ◽  
Contrast Enhanced Ultrasonography

Abstract Background: Contrast-enhanced Ultrasonography Liver Imaging Reporting and Data System (CEUS LI-RADS) released by American College of Radiology was a widely used reporting system for patients at risk with hepatocellular carcinoma (HCC). In CEUS LI-RADS, the categories range from definitely benign (LR-1), probably begin (LR-2), intermediate probability of malignancy (LR-3), probably HCC (LR-4) to definitely HCC (LR-5), malignancy (LR-M), or definite tumor in vein (LR-TIV). Methods: We searched MEDLINE, Web of Science, Cochrane, Embase, and Chinese databases to obtain eligible studies reporting on the diagnostic performance of CEUS LI-RADS in patients at risk for HCC. Results: Twelve studies were eligible in the analysis, including 5275 patients, 5739 observations, and 4066 HCCs. The pooled sensitivity and specificity were 70% (95% Confidence Interval [CI] 65%-74%), 94% (95% CI, 91%-96%) of LR-5 category as predictors of HCC, respectively. The pooled sensitivity and specificity of LR-M category as a predictor of non-HCC malignancy were 83% (95% CI, 71%-91%), 94% (95% CI 88%-97%), respectively. The pooled proportions of HCCs were 1% (95% CI 0%-6%) for LR-2, 20% (95% CI, 9%-34%) for LR-3, 78% (95% CI, 67%-88%) for LR-4, 97% (95% CI, 94%-99%) for LR-5, 40% (95% CI, 23%–58%) for LR-M and 100% (95% CI, 93%–100%) for LR-TIV.Conclusion: CEUS LI-RADS is an important tool for the diagnosis of HCC.

scholarly journals Use of CEUS LI-RADS for the Accurate Diagnosis of Nodules in Patients at Risk for Hepatocellular Carcinoma: A Validation Study

2020 ◽  
Vol 2 (2) ◽  
pp. e190014 ◽  
Author(s):  
Alina Makoyeva ◽  
Tae Kyoung Kim ◽  
Hyun-Jung Jang ◽  
Alejandra Medellin ◽  
Stephanie R. Wilson
Keyword(s):  
Hepatocellular Carcinoma ◽  
At Risk ◽  
Validation Study ◽  
Accurate Diagnosis ◽  
Patients At Risk

scholarly journals Interleukin 28 Polymorphisms and Hepatocellular Carcinoma Development after Direct Acting Antiviral Therapy for Chronic Hepatitis C

2019 ◽  
Vol 28 (4) ◽  
pp. 449-456 ◽  
Author(s):  
Angelo Simili ◽  
Giuseppe Mazzella ◽  
Federico Ravaioli ◽  
Davide Festi ◽  
Maria Letizia Bacchi-Reggiani ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
At Risk ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
De Novo ◽  
Previous History ◽  
Virologic Response ◽  
Retinol Binding Protein ◽  
Patients At Risk

Background and Aims: Cirrhotic patients with hepatitis C virus (HCV) infection remain at risk of developing hepatocellular carcinoma (HCC) even after the sustained virologic response (SVR). We aimed to evaluate whether the IL28 (rs12979860) single nucleotide polymorphism (SNP) may constitute a predisposing genetic factor and to identify the SVR patients at risk of HCC. Methods: Two hundred patients undergoing DAAs treatment for chronic hepatitis C with advanced fibrosis (F3- F4) were consecutively enrolled. Besides normal routine laboratory testing for HCV, patients’ sera were evaluated also for retinol, retinol-binding protein 4 and the following SNPs: PNPLA3 (rs738409), TM6SF2 (rs58542926), MBOAT7 (rs641738), IL28B (rs12979860), TIMP-1 (rs4898), TIMP-2 (rs8179090), NF-kB promoter (rs28362491). Statistical analyses were conducted using Stata/SE 14.2 statistical software (Stata Corp, College Station, TX). Results: Almost all patients (197/200) obtained SVR24. Seventeen patients had a previous history of treated HCC before DAAs. Six patients developed HCC recurrence and five patients developed de novo HCC after a mean period of 18 months since EOT. All these patients had SVR. A significant association between IL28B – TT genotype and HCC development after DAAs therapy was observed (OR 4.728, CI 95% 1.222 – 18.297, p=0.024). Conclusion: IL28B rs12979860 polymorphism was significantly associated with HCC development after DAAs. Assessment of this SNP may better identify patients at risk of developing HCC after treatment. Further prospective studies are required to confirm these hypotheses.

scholarly journals Evaluation of an abbreviated screening MRI protocol for patients at risk for hepatocellular carcinoma

2017 ◽  
Vol 43 (7) ◽  
pp. 1627-1633 ◽  
Author(s):  
Jennifer Y. Lee ◽  
Eugene J. Huo ◽  
Stefanie Weinstein ◽  
Charmaine Santos ◽  
Alexander Monto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
At Risk ◽  
Patients At Risk ◽  
Mri Protocol
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