Intravoxel incoherent motion MRI for predicting early response to induction chemotherapy and chemoradiotherapy in patients with nasopharyngeal carcinoma

2015 ◽  
Vol 43 (5) ◽  
pp. 1179-1190 ◽  
Author(s):  
Yu Xiao-ping ◽  
Hou Jing ◽  
Li Fei-ping ◽  
Hu Yin ◽  
Lu Qiang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Induction Chemotherapy ◽  
Early Response ◽  
Intravoxel Incoherent Motion ◽  
Motion Mri

scholarly journals To predict the radiosensitivity of nasopharyngeal carcinoma using intravoxel incoherent motion MRI at 3.0 T

Oncotarget ◽  
2017 ◽  
Vol 8 (32) ◽  
pp. 53740-53750 ◽  
Author(s):  
Wen Bo Chen ◽  
Bin Zhang ◽  
Long Liang ◽  
Yu Hao Dong ◽  
Guan Hui Cai ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Intravoxel Incoherent Motion ◽  
3.0 T ◽  
Motion Mri

scholarly journals Percent change in apparent diffusion coefficient and plasma EBV DNA after induction chemotherapy identifies distinct prognostic response phenotypes in advanced nasopharyngeal carcinoma

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Li-Ting Liu ◽  
Shan-Shan Guo ◽  
Hui Li ◽  
Chao Lin ◽  
Rui Sun ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Nasopharyngeal Carcinoma ◽  
Apparent Diffusion Coefficient ◽  
Treatment Response ◽  
Induction Chemotherapy ◽  
Early Response ◽  
Adc Value ◽  
Percent Change ◽  
Apparent Diffusion ◽  
Ebv Dna

Abstract Background To evaluate the prognostic value of the apparent diffusion coefficient (ADC) derived from diffusion-weighted magnetic resonance imaging (MRI) and monitor the early treatment response to induction chemotherapy (IC) with plasma EBV DNA in locoregionally advanced nasopharyngeal carcinoma (LA-NPC). Results A total of 307 stage III-IVb NPC patients were prospectively enrolled. All patients underwent MRI examinations to calculate ADC and plasma EBV DNA measurements pretreatment and post-IC. The participants’ ADC value of 92.5% (284/307) increased post-IC. A higher percent change in ADC value (ΔADC%high group) post-IC was associated with a higher 5-year OS rate (90.7% vs 74.9%, p < 0.001) than those in the ΔADC%low group. Interestingly, ΔADC% was closely related to the response measured by RECIST 1.1 (p < 0.001) and plasma EBV DNA level (p = 0.037). The AUC significantly increased when post-IC plasma EBV DNA was added to ΔADC% to predict treatment failure. Thus, based on ΔADC% and plasma EBV DNA, we further divided the participants into three new prognostic response phenotypes (early response, intermediate response, and no response) that correlated with disparate risks of death (p = 0.001), disease progression (p < 0.001), distant metastasis (p < 0.001), and locoregional relapse (p < 0.001). Conclusion The percentage change in ADC post-IC is indicative of treatment response and clinical outcome. ΔADC% and plasma EBV DNA-based response phenotypes may provide potential utility for early termination of treatment and allow guiding risk-adapted therapeutic strategies for LA-NPC.

scholarly journals Comparison of the pre-treatment functional MRI metrics’ efficacy in predicting Locoregionally advanced nasopharyngeal carcinoma response to induction chemotherapy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Da-wei Zhao ◽  
Wen-jun Fan ◽  
Ling-ling Meng ◽  
Yan-rong Luo ◽  
Jian Wei ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Functional Mri ◽  
Induction Chemotherapy ◽  
Primary Tumor ◽  
Early Response ◽  
Diffusion Kurtosis Imaging ◽  
Clinical Trial Registry ◽  
Mean Values ◽  
Significant Difference ◽  
Before And After

Abstract Background Functional MRI (fMRI) parameters analysis has been proven to be a promising tool of predicting therapeutic response to induction chemotherapy (IC) in nasopharyngeal carcinoma (NPC). The study was designed to identify and compare the value of fMRI parameters in predicting early response to IC in patients with NPC. Methods This prospective study enrolled fifty-six consecutively NPC patients treated with IC from January 2021 to May 2021. Conventional diffusion weighted imaging (DWI), diffusion kurtosis imaging (DKI), intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) protocols were performed before and after IC. Parameters maps (ADC, MD, MK, Dslow, Dfast, PF, Ktrans, Ve and Kep) of the primary tumor were calculated by the Functool post-processing software. The participants were classified as responding group (RG) and non-responding group (NRG) according to Response Evaluation Criteria in Solid Tumors 1.1. The fMRI parameters were compared before and after IC and between RG with NRG. Logistic regression analysis and ROC were performed to further identify and compare the efficacy of the parameters. Results After IC, the mean values of ADC(p < 0.001), MD(p < 0.001), Dslow(p = 0.001), PF(p = 0.030) and Ve(p = 0.003) significantly increased, while MK(p < 0.001), Dfast(p = 0.009) and Kep(p = 0.003) values decreased dramatically, while no significant difference was detected in Ktrans(p = 0.130). Compared with NRG, ADC-pre(p < 0.001), MD-pre(p < 0.001) and Dslow-pre(p = 0.002) values in RG were lower, while MK-pre(p = 0.017) values were higher. The areas under the ROC curves for the ADC-pre, MD-pre, MK-pre, Dslow-pre and PRE were 0.885, 0.855, 0.809, 0.742 and 0.912, with the optimal cutoff value of 1210 × 10− 6 mm2/s, 1010 × 10− 6 mm2/s, 832 × 10− 6, 835 × 10− 6 mm2/s and 0.799 respectively. Conclusions The pretreatment conventional DWI (ADC), DKI (MD and MK), and IVIM (Dslow) values derived from fMRI showed a promising potential in predicting the response of the primary tumor to IC in NPC patients. Trial registration This study was approved by ethics board of the Chinese PLA General Hospital, and registered on January 30, 2021, in Chinese Clinical Trial Registry (ChiCTR2100042863).

scholarly journals Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site

2014 ◽  
Vol 24 (8) ◽  
pp. 1998-2004 ◽  
Author(s):  
Shui-xing Zhang ◽  
Qian-jun Jia ◽  
Zhong-ping Zhang ◽  
Chang-hong Liang ◽  
Wen-bo Chen ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Primary Site ◽  
Intravoxel Incoherent Motion ◽  
Motion Mri

Development of imaging biomarker for esophageal cancer using intravoxel incoherent motion MRI

Esophagus ◽  
2021 ◽  
Author(s):  
Ryoya Mizumachi ◽  
Koichi Hayano ◽  
Atsushi Hirata ◽  
Gaku Ohira ◽  
Shunsuke Imanishi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Intravoxel Incoherent Motion ◽  
Imaging Biomarker ◽  
Motion Mri
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