scholarly journals In vivo quantitative whole-brain T1 rho MRI of multiple sclerosis

2015 ◽  
Vol 42 (6) ◽  
pp. 1623-1630 ◽  
Author(s):  
Jay V. Gonyea ◽  
Richard Watts ◽  
Angela Applebee ◽  
Trevor Andrews ◽  
Scott Hipko ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Whole Brain ◽  
T1 Rho

scholarly journals Metabolic counterparts of sodium accumulation in multiple sclerosis: A whole brain 23Na-MRI and fast 1H-MRSI study

2017 ◽  
Vol 25 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Maxime Donadieu ◽  
Yann Le Fur ◽  
Adil Maarouf ◽  
Soraya Gherib ◽  
Ben Ridley ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Regression Models ◽  
Whole Brain ◽  
Sodium Accumulation ◽  
Normal Appearing White Matter ◽  
Clinical Scores ◽  
Z Scores ◽  
Relapsing Remitting Multiple Sclerosis

Background: Increase of brain total sodium concentrations (TSC) is present in multiple sclerosis (MS), but its pathological involvement has not been assessed yet. Objective: To determine in vivo the metabolic counterpart of brain sodium accumulation. Materials/methods: Whole brain 23Na-MR imaging and 3D-1H-EPSI data were collected in 21 relapsing-remitting multiple sclerosis (RRMS) patients and 20 volunteers. Metabolites and sodium levels were extracted from several regions of grey matter (GM), normal-appearing white matter (NAWM) and white matter (WM) T2 lesions. Metabolic and ionic levels expressed as Z-scores have been averaged over the different compartments and used to explain sodium accumulations through stepwise regression models. Results: MS patients showed significant 23Na accumulations with lower choline and glutamate–glutamine (Glx) levels in GM; 23Na accumulations with lower N-acetyl aspartate (NAA), Glx levels and higher Myo-Inositol (m-Ins) in NAWM; and higher 23Na, m-Ins levels with lower NAA in WM T2 lesions. Regression models showed associations of TSC increase with reduced NAA in GM, NAWM and T2 lesions, as well as higher total-creatine, and smaller decrease of m-Ins in T2 lesions. GM Glx levels were associated with clinical scores. Conclusion: Increase of TSC in RRMS is mainly related to neuronal mitochondrial dysfunction while dysfunction of neuro-glial interactions within GM is linked to clinical scores.

In vivo whole-brain T1-rho mapping across adulthood: Normative values and age dependence

2013 ◽  
Vol 40 (2) ◽  
pp. 376-382 ◽  
Author(s):  
Richard Watts ◽  
Trevor Andrews ◽  
Scott Hipko ◽  
Jay V. Gonyea ◽  
Christopher G. Filippi
Keyword(s):  
Normative Values ◽  
Age Dependence ◽  
Whole Brain ◽  
T1 Rho

scholarly journals Imaging Multiple Sclerosis Pathology at 160μm Isotropic Resolution by Human Whole-Brain Ex Vivo Magnetic Resonance Imaging at 3T

2021 ◽  
Author(s):  
Weigel Matthias ◽  
Dechent Peter ◽  
Galbusera Riccardo ◽  
Bahn Erik ◽  
Nair Govind ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Human Brain ◽  
Ex Vivo ◽  
Molecular Layer ◽  
Cortical Lesion ◽  
Resonance Imaging ◽  
Whole Brain

AbstractPostmortem magnetic resonance imaging (MRI) of the fixed healthy and diseased human brain facilitates spatial resolutions and image quality that is not achievable with in vivo MRI scans. Though challenging - and almost exclusively performed at 7T field strength - depicting the tissue architecture of the entire brain in fine detail is invaluable since it enables the study of neuroanatomy and uncovers important pathological features in neurological disorders. The objectives of the present work were (i) to develop a 3D isotropic ultra-high-resolution imaging approach for human whole-brain ex vivo acquisitions working on a standard clinical 3T MRI system, and (ii) to explore the sensitivity and specificity of this concept for specific pathoanatomical features of multiple sclerosis. The reconstructed images demonstrate unprecedented resolution and soft tissue contrast of the diseased human brain at 3T, thus allowing visualization of sub-millimetric lesions in the different cortical layers and in the cerebellar cortex, as well as unique cortical lesion characteristics such as the presence of incomplete / complete iron rims, and patterns of iron accumulation. Further details such as the subpial molecular layer, the line of Gennari, and some intrathalamic nuclei are also well distinguishable.

scholarly journals Imaging multiple sclerosis pathology at 160 μm isotropic resolution by human whole-brain ex vivo magnetic resonance imaging at 3 T

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Matthias Weigel ◽  
Peter Dechent ◽  
Riccardo Galbusera ◽  
Erik Bahn ◽  
Govind Nair ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Human Brain ◽  
Ex Vivo ◽  
Molecular Layer ◽  
Cortical Lesion ◽  
Resonance Imaging ◽  
Whole Brain

AbstractPostmortem magnetic resonance imaging (MRI) of the fixed healthy and diseased human brain facilitates spatial resolutions and image quality that is not achievable with in vivo MRI scans. Though challenging—and almost exclusively performed at 7 T field strength—depicting the tissue architecture of the entire brain in fine detail is invaluable since it enables the study of neuroanatomy and uncovers important pathological features in neurological disorders. The objectives of the present work were (1) to develop a 3D isotropic ultra-high-resolution imaging approach for human whole-brain ex vivo acquisitions working on a standard clinical 3 T MRI system; and (2) to explore the sensitivity and specificity of this concept for specific pathoanatomical features of multiple sclerosis. The reconstructed images demonstrate unprecedented resolution and soft tissue contrast of the diseased human brain at 3 T, thus allowing visualization of sub-millimetric lesions in the different cortical layers and in the cerebellar cortex, as well as unique cortical lesion characteristics such as the presence of incomplete/complete iron rims, and patterns of iron accumulation. Further details such as the subpial molecular layer, the line of Gennari, and some intrathalamic nuclei are also well distinguishable.

Whole brain in vivo axonal diameter mapping in multiple sclerosis

2019 ◽  
Author(s):  
Silvia De Santis ◽  
Elena Herranz ◽  
Constantina A. Treaba ◽  
Valeria Barletta ◽  
Ambica Mehndiratta ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Whole Brain ◽  
Axonal Diameter

scholarly journals 2D in-vivo L-COSY spectroscopy identifies neurometabolite alterations in treated multiple sclerosis

2019 ◽  
Vol 12 ◽  
pp. 175628641987708 ◽  
Author(s):  
Scott Quadrelli ◽  
Karen Ribbons ◽  
Jameen Arm ◽  
Oun Al-iedani ◽  
Jeannette Lechner-Scott ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Symptoms ◽  
Brain Lesion ◽  
Nonparametric Tests ◽  
Correlation Spectroscopy ◽  
Resonance Spectroscopy ◽  
Attention And Memory ◽  
Lesion Volume ◽  
Whole Brain

Background: We have applied in vivo two-dimensional (2D) localized correlation spectroscopy (2D L-COSY), in treated relapsing relapsing-remitting multiple sclerosis (RRMS) to identify novel biomarkers in normal-appearing brain parenchyma. Methods: 2D L-COSY magnetic resonance spectroscopy (MRS) spectra were prospectively acquired from the posterior cingulate cortex (PCC) in 45 stable RRMS patients undergoing treatment with Fingolimod, and 40 age and sex-matched healthy control (HC) participants. Average metabolite ratios and clinical symptoms including, disability, cognition, fatigue, and mental health parameters were measured, and compared using parametric and nonparametric tests. Whole brain volume and MRS voxel morphometry were evaluated using SIENAX and the SPM LST toolbox. Results: Despite the mean whole brain lesion volume being low in this RRMS group (6.8 ml) a significant reduction in PCC metabolite to tCr ratios were identified for multiple N-acetylaspartate (NAA) signatures, gamma-aminobutyric acid (GABA), glutamine and glutamate (Glx), threonine, and isoleucine/lipid. Of the clinical symptoms measured, visuospatial function, attention, and memory were correlated with NAA signatures, Glx, and isoleucine/lipid in the brain. Conclusions: 2D L-COSY has the potential to detect metabolic alterations in the normal-appearing MS brain. Despite examining only a localised region, we could detect metabolic variability associated with symptoms.

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