Simultaneous assessment of vessel size index, relative blood volume, and vessel permeability in a mouse brain tumor model using a combined spin echo gradient echo echo-planar imaging sequence and viable tumor analysis

2014 ◽  
Vol 40 (6) ◽  
pp. 1310-1318 ◽  
Author(s):  
Fabian Kording ◽  
Claudia Weidensteiner ◽  
Stefan Zwick ◽  
Nadja Osterberg ◽  
Astrid Weyerbrock ◽  
...  
Keyword(s):  
Spin Echo ◽  
Tumor Model ◽  
Planar Imaging ◽  
Imaging Sequence ◽  
Size Index ◽  
Brain Tumor Model ◽  
Relative Blood Volume ◽  
Echo Planar ◽  
Echo Planar Imaging Sequence ◽  
Simultaneous Assessment

scholarly journals Simultaneous Perfusion and Permeability Measurements Using Combined Spin- and Gradient-Echo MRI

2013 ◽  
Vol 33 (5) ◽  
pp. 732-743 ◽  
Author(s):  
Heiko Schmiedeskamp ◽  
Jalal B Andre ◽  
Matus Straka ◽  
Thomas Christen ◽  
Seema Nagpal ◽  
...  
Keyword(s):  
Cerebral Blood Volume ◽  
Spin Echo ◽  
Mean Transit Time ◽  
Brain Perfusion ◽  
Gradient Echo ◽  
Planar Imaging ◽  
Imaging Sequence ◽  
Tissue Characteristics ◽  
Echo Planar ◽  
Good Agreement

The purpose of this study was to estimate magnetic resonance imaging-based brain perfusion parameters from combined multiecho spin-echo and gradient-echo acquisitions, to correct them for T1-, T2-, and T∗2-related contrast agent (CA) extravasation effects, and to simultaneously determine vascular permeability. Perfusion data were acquired using a combined multiecho spin- and gradient-echo (SAGE) echo-planar imaging sequence, which was corrected for CA extravasation effects using pharmacokinetic modeling. The presented method was validated in simulations and brain tumor patients, and compared with uncorrected single-echo and multiecho data. In the presence of CA extravasation, uncorrected single-echo data resulted in underestimated CA concentrations, leading to underestimated single-echo cerebral blood volume ( CBV) and mean transit time ( MTT). In contrast, uncorrected multiecho data resulted in overestimations of CA concentrations, CBV, and MTT. The correction of CA extravasation effects resulted in CBV and MTT estimates that were more consistent with the underlying tissue characteristics. Spin-echo perfusion data showed reduced large-vessel blooming effects, facilitating better distinction between increased CBV due to active tumor progression and elevated CBV due to the presence of cortical vessels in tumor proximity. Furthermore, extracted permeability parameters were in good agreement with elevated T1-weighted postcontrast signal values.

scholarly journals Detection of Myocardial Edema with Low-b-value Diffusion-weighted Echo-planar Imaging Sequence in Patients with Acute Myocarditis

Radiology ◽  
2013 ◽  
Vol 269 (2) ◽  
pp. 362-369 ◽  
Author(s):  
Julien Potet ◽  
Alain Rahmouni ◽  
Julie Mayer ◽  
Alexandre Vignaud ◽  
Pascal Lim ◽  
...  
Keyword(s):  
Acute Myocarditis ◽  
Myocardial Edema ◽  
B Value ◽  
Echo Planar Imaging ◽  
Planar Imaging ◽  
Diffusion Weighted ◽  
Imaging Sequence ◽  
Echo Planar ◽  
Echo Planar Imaging Sequence

scholarly journals Susceptibility compensated fMRI study using a tailored RF echo planar imaging sequence

2009 ◽  
Vol 29 (1) ◽  
pp. 221-228 ◽  
Author(s):  
Jun-Young Chung ◽  
Hyo Woon Yoon ◽  
Young-Bo Kim ◽  
Hyun Wook Park ◽  
Zang-Hee Cho
Keyword(s):  
Echo Planar Imaging ◽  
Planar Imaging ◽  
Imaging Sequence ◽  
Fmri Study ◽  
Echo Planar ◽  
Echo Planar Imaging Sequence
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