scholarly journals T1 bias in chemical shift-encoded liver fat-fraction: Role of the flip angle

2013 ◽  
Vol 40 (4) ◽  
pp. 875-883 ◽  
Author(s):  
Jens-Peter Kühn ◽  
Christina Jahn ◽  
Diego Hernando ◽  
Werner Siegmund ◽  
Stefan Hadlich ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Flip Angle ◽  
Liver Fat ◽  
Fat Fraction

scholarly journals High Fat Activates O-GlcNAcylation and Affects AMPK/ACC Pathway to Regulate Lipid Metabolism

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1740
Author(s):  
Yuning Pang ◽  
Xiang Xu ◽  
Xiaojun Xiang ◽  
Yongnan Li ◽  
Zengqi Zhao ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
Lipid Synthesis ◽  
Fat Deposition ◽  
Liver Fat ◽  
Lipid Homeostasis ◽  
High Fat ◽  
Dual Inhibitor ◽  
Regulate Lipid Metabolism

A high-fat diet often leads to excessive fat deposition and adversely affects the organism. However, the mechanism of liver fat deposition induced by high fat is still unclear. Therefore, this study aimed at acetyl-CoA carboxylase (ACC) to explore the mechanism of excessive liver deposition induced by high fat. In the present study, the ORF of ACC1 and ACC2 were cloned and characterized. Meanwhile, the mRNA and protein of ACC1 and ACC2 were increased in liver fed with a high-fat diet (HFD) or in hepatocytes incubated with oleic acid (OA). The phosphorylation of ACC was also decreased in hepatocytes incubated with OA. Moreover, AICAR dramatically improved the phosphorylation of ACC, and OA significantly inhibited the phosphorylation of the AMPK/ACC pathway. Further experiments showed that OA increased global O-GlcNAcylation and agonist of O-GlcNAcylation significantly inhibited the phosphorylation of AMPK and ACC. Importantly, the disorder of lipid metabolism caused by HFD or OA could be rescued by treating CP-640186, the dual inhibitor of ACC1 and ACC2. These observations suggested that high fat may activate O-GlcNAcylation and affect the AMPK/ACC pathway to regulate lipid synthesis, and also emphasized the importance of the role of ACC in lipid homeostasis.

scholarly journals Temperature‐corrected proton density fat fraction estimation using chemical shift‐encoded MRI in phantoms

2021 ◽  
Vol 86 (1) ◽  
pp. 69-81 ◽  
Author(s):  
Ruvini Navaratna ◽  
Ruiyang Zhao ◽  
Timothy J. Colgan ◽  
Houchun Harry Hu ◽  
Mark Bydder ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Proton Density ◽  
Proton Density Fat Fraction ◽  
Fat Fraction

scholarly journals Association of Thigh Muscle Strength with Texture Features Based on Proton Density Fat Fraction Maps Derived from Chemical Shift Encoding-Based Water–Fat MRI

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 302
Author(s):  
Michael Dieckmeyer ◽  
Stephanie Inhuber ◽  
Sarah Schläger ◽  
Dominik Weidlich ◽  
Muthu R. K. Mookiah ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Muscle Strength ◽  
Neuromuscular Disorders ◽  
Texture Features ◽  
Thigh Muscle ◽  
Proton Density ◽  
Proton Density Fat Fraction ◽  
Thigh Muscles ◽  
Fat Fraction ◽  
Flexion Strength

Purpose: Based on conventional and quantitative magnetic resonance imaging (MRI), texture analysis (TA) has shown encouraging results as a biomarker for tissue structure. Chemical shift encoding-based water–fat MRI (CSE-MRI)-derived proton density fat fraction (PDFF) of thigh muscles has been associated with musculoskeletal, metabolic, and neuromuscular disorders and was demonstrated to predict muscle strength. The purpose of this study was to investigate PDFF-based TA of thigh muscles as a predictor of thigh muscle strength in comparison to mean PDFF. Methods: 30 healthy subjects (age = 30 ± 6 years; 15 females) underwent CSE-MRI of the lumbar spine at 3T, using a six-echo 3D spoiled gradient echo sequence. Quadriceps (EXT) and ischiocrural (FLEX) muscles were segmented to extract mean PDFF and texture features. Muscle flexion and extension strength were measured with an isokinetic dynamometer. Results: Of the eleven extracted texture features, Variance(global) showed the highest significant correlation with extension strength (p < 0.001, R2adj = 0.712), and Correlation showed the highest significant correlation with flexion strength (p = 0.016, R2adj = 0.658). Multivariate linear regression models identified Variance(global) and sex, but not PDFF, as significant predictors of extension strength (R2adj = 0.709; p < 0.001), while mean PDFF, sex, and BMI, but none of the texture features, were identified as significant predictors of flexion strength (R2adj = 0.674; p < 0.001). Conclusions: Prediction of quadriceps muscle strength can be improved beyond mean PDFF by means of TA, indicating the capability to quantify muscular fat infiltration patterns.

scholarly journals Effect of microscopic susceptibility gradients on chemical-shift-based fat fraction quantification in supraclavicular fat

2018 ◽  
Vol 49 (1) ◽  
pp. 141-151 ◽  
Author(s):  
Drew McCallister ◽  
Le Zhang ◽  
Alex Burant ◽  
Laurence Katz ◽  
Rosa Tamara Branca
Keyword(s):  
Chemical Shift ◽  
Fat Fraction

scholarly journals Diurnal Variation of Proton Density Fat Fraction in the Liver Using Quantitative Chemical Shift Encoded MRI

2019 ◽  
Vol 51 (2) ◽  
pp. 407-414
Author(s):  
Timothy J. Colgan ◽  
Andrew J. Van Pay ◽  
Samir D. Sharma ◽  
Lu Mao ◽  
Scott B. Reeder
Keyword(s):  
Chemical Shift ◽  
Diurnal Variation ◽  
Proton Density ◽  
Proton Density Fat Fraction ◽  
Fat Fraction ◽  
Quantitative Chemical

scholarly journals Adipokines in Nonalcoholic Steatohepatitis: From Pathogenesis to Implications in Diagnosis and Therapy

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Emmanuel A. Tsochatzis ◽  
George V. Papatheodoridis ◽  
Athanasios J. Archimandritis
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Experimental Models ◽  
Liver Fat ◽  
Nonalcoholic Fatty Liver ◽  
The Metabolic Syndrome ◽  
Noninvasive Markers ◽  
End Stage ◽  
Multiple Hit

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and can vary from benign steatosis to end-stage liver disease. The pathogenesis of non-alcoholic steatohepatitis (NASH) is currently thought to involve a multiple-hit process with the first hit being the accumulation of liver fat which is followed by the development of necroinflammation and fibrosis. There is mounting evidence that cytokines secreted from adipose tissue, namely, adipokines, are implicated in the pathogenesis and progression of NAFLD. In the current review, we explore the role of these adipokines, particularly leptin, adiponectin, resistin, tumor necrosis factor-a, and interleukin-6 in NASH, as elucidated in experimental models and clinical practice. We also comment on their potential use as noninvasive markers for differentiating simple fatty liver from NASH as well as on their potential future therapeutic role in patients with NASH.

scholarly journals Serum Scoring and Quantitative Magnetic Resonance Imaging in Intestinal Failure-Associated Liver Disease: A Feasibility Study

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2151
Author(s):  
Konstantinos C. Fragkos ◽  
María Claudia Picasso Bouroncle ◽  
Shankar Kumar ◽  
Lucy Caselton ◽  
Alex Menys ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Diseases ◽  
Liver Blood Flow ◽  
Intestinal Failure ◽  
Quantitative Mri ◽  
Liver Fat ◽  
Gamma Glutamyl Transferase ◽  
Small Bowel Motility ◽  
Fat Fraction ◽  
Glutamyl Transferase

(1) Background: Intestinal failure-associated liver disease (IFALD) in adults is characterized by steatosis with variable progression to fibrosis/cirrhosis. Reference standard liver biopsy is not feasible for all patients, but non-invasive serological and quantitative MRI markers for diagnosis/monitoring have not been previously validated. Here, we examine the potential of serum scores and feasibility of quantitative MRI used in non-IFALD liver diseases for the diagnosis of IFALD steatosis; (2) Methods: Clinical and biochemical parameters were used to calculate serum scores in patients on home parenteral nutrition (HPN) with/without IFALD steatosis. A sub-group underwent multiparameter quantitative MRI measurements of liver fat fraction, iron content, tissue T1, liver blood flow and small bowel motility; (3) Results: Compared to non-IFALD (n = 12), patients with IFALD steatosis (n = 8) demonstrated serum score elevations in Enhanced Liver Fibrosis (p = 0.032), Aspartate transaminase-to-Platelet Ratio Index (p < 0.001), Fibrosis-4 Index (p = 0.010), Forns Index (p = 0.001), Gamma-glutamyl transferase-to-Platelet Ratio Index (p = 0.002) and Fibrosis Index (p = 0.001). Quantitative MRI scanning was feasible in all 10 sub-group patients. Median liver fat fraction was higher in IFALD steatosis patients (10.9% vs 2.1%, p = 0.032); other parameter differences were non-significant; (4) Conclusion: Serum scores used for non-IFALD liver diseases may be useful in IFALD steatosis. Multiparameter MRI is feasible in patients on HPN.

Sign in / Sign up

Export Citation Format

Share Document