scholarly journals Subcompartmentalization of extracellular extravascular space (EES) into permeability and leaky space with local arterial input function (AIF) results in improved discrimination between high- and low-grade glioma using dynamic contrast-enhanced (DCE) MRI

2013 ◽  
Vol 38 (3) ◽  
pp. spcone-spcone
Author(s):  
Prativa Sahoo ◽  
Ram K.S. Rathore ◽  
Rishi Awasthi ◽  
Bhaswati Roy ◽  
Sanjay Verma ◽  
...  
Keyword(s):  
Arterial Input Function ◽  
Input Function ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Extravascular Space ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

scholarly journals Effects of artery input function on dynamic contrast-enhanced MRI for determining grades of gliomas

2020 ◽  
pp. 20200699
Author(s):  
Lin Jia ◽  
Xia Wu ◽  
Qian Wan ◽  
Liwen Wan ◽  
Wenxiao Jia ◽  
...  
Keyword(s):  
Cerebral Artery ◽  
Input Function ◽  
P Value ◽  
Low Grade ◽  
High Grade ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Quantitative Parameters ◽  
Contrast Enhanced ◽  
High Grade Gliomas

Objective: To evaluate the effect of artery input function (AIF) derived from different arteries for pharmacokinetic modeling on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters in the grading of gliomas. Methods: 49 patients with pathologically confirmed gliomas were recruited and underwent DCE-MRI. A modified Tofts model with different AIFs derived from anterior cerebral artery (ACA), ipsilateral and contralateral middle cerebral artery (MCA) and posterior cerebral artery (PCA) was used to estimate quantitative parameters such as Ktrans (volume transfer constant) and Ve (fractional extracellular-extravascular space volume) for distinguishing the low grade glioma from high grade glioma. The Ktrans and Ve were compared between different arteries using Two Related Samples Tests (TRST) (i.e. Wilcoxon Signed Ranks Test). In addition, these parameters were compared between the low and high grades as well as between the grade II and III using the Mann-Whitney U-test. A p-value of less than 0.05 was regarded as statistically significant. Results: All the patients completed the DCE-MRI successfully. Sharp wash-in and wash-out phases were observed in all AIFs derived from the different arteries. The quantitative parameters (Ktrans and Ve) calculated from PCA were significant higher than those from ACA and MCA for low and high grades, respectively (p < 0.05). Despite the differences of quantitative parameters derived from ACA, MCA and PCA, the Ktrans and Ve from any AIFs could distinguish between low and high grade, however, only Ktrans from any AIFs could distinguish grades II and III. There was no significant correlation between parameters and the distance from the artery, which the AIF was extracted, to the tumor. Conclusion: Both quantitative parameters Ktrans and Ve calculated using any AIF of ACA, MCA, and PCA can be used for distinguishing the low- from high-grade gliomas, however, only Ktrans can distinguish grades II and III. Advances in knowledge: We sought to assess the effect of AIF on DCE-MRI for determining grades of gliomas. Both quantitative parameters Ktrans and Ve calculated using any AIF of ACA, MCA, and PCA can be used for distinguishing the low- from high-grade gliomas.

scholarly journals Phase-based arterial input function measurements in the femoral arteries for quantification of dynamic contrast-enhanced (DCE) MRI and comparison with DCE-CT

2011 ◽  
Vol 66 (5) ◽  
pp. 1267-1274 ◽  
Author(s):  
Johannes G. Korporaal ◽  
Cornelis A. T. van den Berg ◽  
Matthias J. P. van Osch ◽  
Greetje Groenendaal ◽  
Marco van Vulpen ◽  
...  
Keyword(s):  
Arterial Input Function ◽  
Input Function ◽  
Dce Mri ◽  
Femoral Arteries ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

scholarly journals Effect of parallel radiofrequency transmission on arterial input function selection in dynamic contrast-enhanced 3 Tesla pelvic MRI

2015 ◽  
Vol 43 (1) ◽  
pp. 229-235
Author(s):  
Hatim Chafi ◽  
Saba N. Elias ◽  
Huyen T. Nguyen ◽  
Harry T. Friel ◽  
Michael V. Knopp ◽  
...  
Keyword(s):  
Arterial Input Function ◽  
Input Function ◽  
3 Tesla ◽  
Pelvic Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Function Selection

Blind estimation of the arterial input function in dynamic contrast-enhanced MRI using purity maximization

2012 ◽  
Vol 68 (5) ◽  
pp. 1439-1449 ◽  
Author(s):  
Yu-Chun Lin ◽  
Tsung-Han Chan ◽  
Chong-Yung Chi ◽  
Shu-Hang Ng ◽  
Hao-Li Liu ◽  
...  
Keyword(s):  
Arterial Input Function ◽  
Input Function ◽  
Blind Estimation ◽  
Dynamic Contrast Enhanced Mri ◽  
Dynamic Contrast Enhanced ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Contrast Enhanced Mri
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