Cerebral arterial and venous blood flow in adolescent multiple sclerosis patients and age-matched controls using phase contrast MRI

2013 ◽  
Vol 40 (2) ◽  
pp. 341-347 ◽  
Author(s):  
Christopher K. Macgowan ◽  
Katherine Y. Chan ◽  
Suzanne Laughlin ◽  
Ruth Ann Marrie ◽  
Brenda Banwell
2003 ◽  
Vol 33 (9) ◽  
pp. 607-613 ◽  
Author(s):  
Emanuela R. Valsangiacomo ◽  
Catherine Barrea ◽  
Christopher K. Macgowan ◽  
Jeffrey F. Smallhorn ◽  
John G. Coles ◽  
...  

2009 ◽  
Vol 29 (12) ◽  
pp. 1867-1878 ◽  
Author(s):  
Ajay Vikram Singh ◽  
Paolo Zamboni

Multiple sclerosis (MS) is primarily an autoimmune disorder of unknown origin. This review focuses iron overload and oxidative stress as surrounding cause that leads to immunomodulation in chronic MS. Iron overload has been demonstrated in MS lesions, as a feature common with other neurodegenerative disorders. However, the recent description of chronic cerebrospinal venous insufficiency (CCSVI) associated to MS, with significant anomalies in cerebral venous outflow hemodynamics, permit to propose a parallel with chronic venous disorders (CVDs) in the mechanism of iron deposition. Abnormal cerebral venous reflux is peculiar to MS, and was not found in a miscellaneous of patients affected by other neurodegenerative disorders characterized by iron stores, such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis. Several recently published studies support the hypothesis that MS progresses along the venous vasculature. The peculiarity of CCSVI-related cerebral venous blood flow disturbances, together with the histology of the perivenous spaces and recent findings from advanced magnetic resonance imaging techniques, support the hypothesis that iron deposits in MS are a consequence of altered cerebral venous return and chronic insufficient venous drainage.


JAMA ◽  
1966 ◽  
Vol 198 (7) ◽  
pp. 784-785 ◽  
Author(s):  
A. Neistadt

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