scholarly journals Relationships between hypercarbic reactivity, cerebral blood flow, and arterial circulation times in patients with moyamoya disease

2013 ◽  
Vol 38 (5) ◽  
pp. 1129-1139 ◽  
Author(s):  
Manus J. Donahue ◽  
Michael Ayad ◽  
Ryan Moore ◽  
Matthias van Osch ◽  
Robert Singer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Moyamoya Disease ◽  
Arterial Circulation

Regional cerebral blood flow in pediatric moyamoya disease: age-dependent decline in specific regions

1998 ◽  
Vol 14 (8) ◽  
pp. 366-371 ◽  
Author(s):  
T. Ishikawa ◽  
Naruhiko Tanaka ◽  
Kiyohiro Houkin ◽  
Satoshi Kuroda ◽  
Hiroshi Abe ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Moyamoya Disease ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Age Dependent

Interaction among autoregulation, CO2 reactivity, and intracranial pressure: a mathematical model

1998 ◽  
Vol 274 (5) ◽  
pp. H1715-H1728 ◽  
Author(s):  
Mauro Ursino ◽  
Carlo Alberto Lodi
Keyword(s):  
Mathematical Model ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Intracranial Pressure ◽  
Nonlinear Interaction ◽  
Cerebral Blood Volume ◽  
Cerebral Hemodynamics ◽  
Pial Arteries ◽  
Arterial Circulation ◽  
Neurosurgical Patients

The relationships among cerebral blood flow, cerebral blood volume, intracranial pressure (ICP), and the action of cerebrovascular regulatory mechanisms (autoregulation and CO2 reactivity) were investigated by means of a mathematical model. The model incorporates the cerebrospinal fluid (CSF) circulation, the intracranial pressure-volume relationship, and cerebral hemodynamics. The latter is based on the following main assumptions: the middle cerebral arteries behave passively following transmural pressure changes; the pial arterial circulation includes two segments (large and small pial arteries) subject to different autoregulation mechanisms; and the venous cerebrovascular bed behaves as a Starling resistor. A new aspect of the model exists in the description of CO2 reactivity in the pial arterial circulation and in the analysis of its nonlinear interaction with autoregulation. Simulation results, obtained at constant ICP using various combinations of mean arterial pressure and CO2 pressure, substantially support data on cerebral blood flow and velocity reported in the physiological literature concerning both the separate effects of CO2 and autoregulation and their nonlinear interaction. Simulations performed in dynamic conditions with varying ICP underline the existence of a significant correlation between ICP dynamics and cerebral hemodynamics in response to CO2 changes. This correlation may significantly increase in pathological subjects with poor intracranial compliance and reduced CSF outflow. In perspective, the model can be used to study ICP and blood velocity time patterns in neurosurgical patients in order to gain a deeper insight into the pathophysiological mechanisms leading to intracranial hypertension and secondary brain damage.

scholarly journals Impact of blood pressure changes in cerebral blood perfusion of patients with ischemic Moyamoya disease evaluated by SPECT

2020 ◽  
pp. 0271678X2096745
Author(s):  
Zhao Liming ◽  
Sun Weiliang ◽  
Jia Jia ◽  
Liang Hao ◽  
Liu Yang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Moyamoya Disease ◽  
Emission Computed Tomography ◽  
Study Cohort ◽  
Pressure Changes ◽  
The Impact

Our aim was to determine the impact of targeted blood pressure modifications on cerebral blood flow in ischemic moyamoya disease patients assessed by single-photon emission computed tomography (SPECT). From March to September 2018, we prospectively collected data of 154 moyamoya disease patients and selected 40 patients with ischemic moyamoya disease. All patients underwent in-hospital blood pressure monitoring to determine the mean arterial pressure baseline values. The study cohort was subdivided into two subgroups: (1) Group A or relative high blood pressure (RHBP) with an induced mean arterial pressure 10–20% higher than baseline and (2) Group B or relative low blood pressure (RLBP) including patients with mean arterial pressure 10–20% lower than baseline. All patients underwent initial SPECT study on admission-day, and on the following day, every subgroup underwent a second SPECT study under their respective targeted blood pressure values. In general, RHBP patients showed an increment in perfusion of 10.13% (SD 2.94%), whereas RLBP patients showed a reduction of perfusion of 12.19% (SD 2.68%). Cerebral blood flow of moyamoya disease patients is susceptible to small blood pressure changes, and cerebral autoregulation might be affected due to short dynamic blood pressure modifications.

scholarly journals Imaging of cerebrovascular reserve and oxygenation in Moyamoya disease

2016 ◽  
Vol 37 (4) ◽  
pp. 1213-1222 ◽  
Author(s):  
Wendy W Ni ◽  
Thomas Christen ◽  
Jarrett Rosenberg ◽  
Zungho Zun ◽  
Michael E Moseley ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Moyamoya Disease ◽  
Relaxation Rates ◽  
Flow Mapping ◽  
Cerebrovascular Reserve ◽  
Lower Baseline ◽  
Kendall’S Τ ◽  
Free Induction ◽  
Measured Relaxation

This study aimed to determine whether measurements of cerebrovascular reserve and oxygenation, assessed with spin relaxation rate R2′, yield similar information about pathology in pre-operative Moyamoya disease patients, and to assess whether R2′ is a better measure of oxygenation than other proposed markers, such as R2* and R2. Twenty-five pre-operative Moyamoya disease patients were scanned at 3.0T with acetazolamide challenge. Cerebral blood flow mapping with multi-delay arterial spin labeling, and R2*, R2, and R2′ mapping with Gradient-Echo Sampling of Free Induction Decay and Echo were performed. No baseline cerebral blood flow difference was found between angiographically abnormal and normal regions (49 ± 12 vs. 48 ± 11 mL/100 g/min, p = 0.44). However, baseline R2′ differed between these regions (3.2 ± 0.7 vs. 2.9 ± 0.6 s−1, p < 0.001), indicating reduced oxygenation in abnormal regions. Cerebrovascular reserve was lower in angiographically abnormal regions (21 ± 38 vs. 41 ± 26%, p = 0.001). All regions showed trend toward significantly improved oxygenation post-acetazolamide. Regions with poorer cerebrovascular reserve had lower baseline oxygenation (Kendall's τ = −0.24, p = 0.003). A number of angiographically abnormal regions demonstrated preserved cerebrovascular reserve, likely due to the presence of collaterals. Finally, of the concurrently measured relaxation rates, R2′ was superior for oxygenation assessment.

scholarly journals Cerebral blood flow, transit time, and apparent diffusion coefficient in moyamoya disease before and after acetazolamide

2016 ◽  
Vol 59 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Christian Federau ◽  
Soren Christensen ◽  
Zungho Zun ◽  
Sun-Won Park ◽  
Wendy Ni ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diffusion Coefficient ◽  
Cerebral Blood Flow ◽  
Apparent Diffusion Coefficient ◽  
Transit Time ◽  
Moyamoya Disease ◽  
Before And After ◽  
Apparent Diffusion

Factors of Delayed Hyperperfusion and the Importance of Repeated Cerebral Blood Flow Evaluation for Hyperperfusion After Direct Bypass for Moyamoya Disease

2018 ◽  
Vol 118 ◽  
pp. e468-e472 ◽  
Author(s):  
Shunsuke Nomura ◽  
Koji Yamaguchi ◽  
Tatsuya Ishikawa ◽  
Akitsugu Kawashima ◽  
Yoshikazu Okada ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Moyamoya Disease ◽  
Direct Bypass ◽  
Blood Flow Evaluation

Cerebral blood flow findings in moyamoya disease in adults

2009 ◽  
Vol 85 (5) ◽  
pp. 318-322 ◽  
Author(s):  
E. Dietrichs ◽  
A. Dahl ◽  
R. Nyberg-Hansen ◽  
D. Russell ◽  
K. Rootwelt ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Moyamoya Disease
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